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Supplementary material. S3. Evaluating the methodological quality of case reports and case series with the tool of Murad and colleaguesDomainsCasesSelectionAscertainment

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Supplementary material. S3. Evaluating the methodological quality of case reports and case series with the tool of Murad and colleagues Domains

Cases Selection Ascertainment

a

Causality Reporting

1. Does the patient(s) represent(s) the whole experience of the investigator (centre) or is the selection method unclear to the extent that other patients with similar presentation may not have been reported?

2. Was the exposure adequately ascertained?

3. Was the outcome adequately ascertained?

4. Were other alternative causes that may explain the observation ruled out?

5. Was there a challenge/rechalle nge

phenomenon?

6. Was there a dose–response effect?

7. Was follow-up long enough for outcomes to occur?

8. Is the case(s) described with sufficient details to allow other investigators to replicate the research or to allow practitioners make inferences related to their own practice?

Overall rating

1-Suwanwongse et al.2020 [1]

Case 1 Yes Yes Yes Yes No Yes Yes Yes High quality

2-Suwanwongse et al.2020

Case 2 Yes Yes Yes Yes No Yes Yes Yes High quality

3- Llesuy & Sidelnik, 2020[2] Yes No No Yes No n.a. n.r. n.r. Low quality

4 -Cranshaw & Harikumar,

2020 [3] Yes Yes Yes Yes No n.a. Yes Yes Moderate quality

5- Doston et al. 2020 [4]

Case 1 Yes Yes Yes Yes No n.a. Yes Yes Moderate quality

6- Doston et al. 2020

Case 2 Yes Yes Yes Yes No n.a. Yes Yes Moderate quality

7- Doston et al. 2020

Case 3 Yes Yes Yes Yes No n.a. Yes Yes Moderate quality

8-Sokolov et al. 2020 [5] Yes Yes Yes Yes No Yes Yes Yes High quality

9- Butler et al. 2020[6]

Patient G Yes Yes Yes Yes No Yes Yes Yes High quality

10- Soh et al. 2020 [7]

Case 2 Yes No No Yes No n.a. n.r. Yes Low quality

11- Serrano et al. 2020 [8]

Case 2 Yes No No Yes No n.a. n.r. Yes Low quality

12- Kajani et al. 2020 [9] Yes No No Yes No n.a. n.r. Yes Low quality

13- Serrano et al. 2020

Case 1 Yes No No Yes No n.a n.r. Yes Low quality

a

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Considering that all included patients were affected with the SARS-COV-2, we will focus on the exposure to the psychotropic drug (plasma level of the correspondent drug)

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