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Role of the pol Gene AP-1 Sites for HIV-1 Replication Human Immunodeficiency Virus type 1 Transcriptional and Epigenetic Regulation of Gene Expression Retroviruses Contents

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Contents

Retroviruses

………...p1 1. General properties of Retroviruses……….………..….p1 2. Structure of retroviral virions and genomes……….………….p2 3. Replication cycle of Retroviruses……….………..p4

a. Viral entry and Receptors

b. Viral uncoating and Reverse transcription c. Integration into the host cell genome d. Viral transcription and Protein synthesis e. Virion assembly and Maturation

Transcriptional and Epigenetic Regulation of Gene Expression

……….……..p9 1. A primer on transcriptional regulation of eukaryotic class II promoters……..…………p9 2. Chromatin structure and epigenetic regulation of gene expression………..p11 3. Histone posttranslational modifications ………..….p12

a. Histone acetylation b. Histone methylation

c. DNA methylation at CpG dinucleotides

Human Immunodeficiency Virus type 1

………..………p15 1. Pathogenesis of AIDS……….………p15 2. The Highly Active Antiretroviral Therapy (HAART)………..…………..p17 3. HIV-1 regulatory and accessory proteins………..……….………p18

a. Tat (Transactivator of Transcription) b. Rev (Regulator of Virion)

c. Nef (Negative Factor) d. Vif (Virion Infectivity Factor) e. Vpr (Virion Protein R) f. Vpu (Virion Protein U)

4. Molecular control of HIV-1 expression……….p21 a. Transcriptional regulation of HIV-1 expression

b. Chromatin organization of the HIV-1 provirus c. The intragenic cis-regulatory region of HIV-1

Role of the pol Gene AP-1 Sites for HIV-1 Replication

……….p25

(2)

Characterization of the Intragenic region of the HIV-1 Genome

…..……….…….p30

Molecular Control of HIV-1 Postintegration Latency

……….………....…….p36

Bovine Leukemia Virus

……….…p38 1. Pathogenesis of EBL………p39 2. Mechanisms of Leukemogenesis……….……….p40 3. Viral regulatory and accessory proteins………..…….……….p41

a. TaxBLV

b. RexBLV

c. R3 and G4 accessory proteins

4. Molecular control of BLV expression……….…….……….p42 a. Transcriptional regulation of BLV expression

b. Chromatin and epigenetic regulation of BLV expression

DNA Cytosine Methylation in the BLV Promoter is associated with

Latency

………..…p46

Chromatin Disruption in the BLV promoter during transcriptional

activation

…..……….…p50

General Conclusions

…..……….………..…p55

References

Références

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