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Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study.

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HAL Id: inserm-00707688

https://www.hal.inserm.fr/inserm-00707688

Submitted on 23 May 2013

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Regional dynamics of amyloid-β deposition in healthy

elderly, mild cognitive impairment and Alzheimer’s

disease: a voxelwise PiB-PET longitudinal study.

Nicolas Villain, Gaël Chételat, Blandine Grassiot, Pierrick Bourgeat, Gareth

Jones, Kathryn Ellis, David Ames, Ralph Martins, Francis Eustache, Olivier

Salvado, et al.

To cite this version:

Nicolas Villain, Gaël Chételat, Blandine Grassiot, Pierrick Bourgeat, Gareth Jones, et al.. Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer’s dis-ease: a voxelwise PiB-PET longitudinal study.. Brain - A Journal of Neurology , Oxford University Press (OUP), 2012, epub ahead of print. �10.1093/brain/aws125�. �inserm-00707688�

(2)

Table 1 : Demographics and clinical characteristics of the longitudinal PiB-PET sample.

Memory and Non-Memory Z-Scores are composite neuropsychological scores, obtained from

extensive neuropsychological testing (see Pike et al., 2007 and Villemagne et al., 2011 for

details).

AD

MCI

NC

N

32

49

103

Age (years)

72.6±9.0

74.4±7.3

73.6±7.3

Gender (M/F)

16/16

28/21

48/55

Education (years)

11.9±3.5

12.3±4.1

13.2±3.5

MMSE Baseline

22.2±4.4

26.8±2.4

28.8±1.2

Memory Z-Score Baseline

-3.28±0.56

-2.14±1.00

-0.16±0.86

Non-Memory Z-Score Baseline -2.33±1.50

-0.88±0.86

-0.01±0.65

Follow-Up Duration (years)

1.75±0.45

1.68±0.23

1.67±0.27

Figure

Table 1 : Demographics and clinical characteristics of the longitudinal PiB-PET sample

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