Designed evolution of artificial metalloenzymes: protein catalysts made to order

Le test non paramétrique de Wilcoxon a ensuite été utilisé pour comparer les résultats liés aux quatre dimensions et au score global de l’Inventaire de l’équilibre de

When co-variation analysis aims to gain evolutionary information, OMES and ELSC are well suited to identify the co-evolving residues that contributed to the divergence within

Indeed, similarly to what was inferred from the high- potential data of Av, the inactivation rate is independent of potential over the whole potential range (including the conditions

Abstract: The Mn(TpCPP)-Xln10A artificial metalloenzyme, obtained by non-covalent insertion of Mn(III)-meso-tetrakis(p-carboxyphenyl)porphyrin [Mn(TpCPP), 1-Mn] into xylanase 10A

The ability to optimize or to find new catalysts for enantioselective transformations has a major impact in today’s chemistry. Artificial metalloenzymes lie at

Lu and co-workers recently reported an enantiose- lective artificial sulfoxidation metalloenzyme based on a dual covalent anchoring strategy of a Mn(Schiff base) within Mb (Table

Having demonstrated that the introduction of a short achiral amino acid spacer between the biotin anchor and the rhodium- diphosphine moiety has, in some cases, a positive influence

Based on the incorporation of biotinylated organometallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary