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A comprehensive reduced model of the mammalian cell cycle

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Academic year: 2021

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Fig. 2. Schematic representation of the negative feedback loop between MPF and the APC:cdc20 complex: MPF promotes the formation of APC:cdc20 by activating APC, while APC:cdc20 represses MPF by  degrada-tion
Fig. 3. Oscillations of the components of the cell cycle model. Parameters: wee1 T OT = 22.0, cdc25 T OT = 20.0, AP C T OT = 40.0, cdc20 T OT = 20.0, γ 1 = 3.0, γ2 = 0.1, V 1 = 0.1, k 1 = 7.6, V 2 = 2.5, k 2 = 7.6, V 3 = 0.5, k 3 = 5.4, V 4 = 5.0, k 4 = 4.
Fig. 4. Oscillations of MPF and APC:cdc20 over time.
Fig. 6. Blue curve (g 1 ): MPF nullcline, red curve (g 2 ):
+2

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