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MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

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Academic year: 2021

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Figure

Fig. 1 Correlation of downregulation of ANO1 mRNA and upregulation of miR-9. a miR-9 expression in non-CF (16HBE14o-; n = 5) and CF (CFBE41o-;
Fig. 2 miR-9 regulates ANO1 expression, ANO1 chloride activity, and non-CF cells migration
Fig. 3 miR-9 directly targets ANO1 3 ′ UTR in non-CF and CF cells. a Relative luciferase activity in non-CF cells (16HBE14o-) transiently transfected with a luciferase-3 ′ UTR ANO1 vector or a luciferase-3 ′ UTR ANO1 vector mutated at miR-9-binding sites a
Fig. 4 miR-9-speci fi c TSB increases ANO1 expression, chloride activity, and migration rate
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