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The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

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(1)The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities Jurre Hageman, Maria van Waarde-Verhagen, Alicja Zylicz, Dawid Walerych, Harm H. Kampinga. To cite this version: Jurre Hageman, Maria van Waarde-Verhagen, Alicja Zylicz, Dawid Walerych, Harm H. Kampinga. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochemical Journal, Portland Press, 2011, 435 (1), pp.127-142. �10.1042/BJ20101247�. �hal-00576982�. HAL Id: hal-00576982 https://hal.archives-ouvertes.fr/hal-00576982 Submitted on 16 Mar 2011. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

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(16) Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. ),';%5%;%<=%(%( '%'%%$% >200/@     #  .9             9       9 .)% %%:: /*/1./*18. us cri pt. )8 ' ;%  (  '% '% >200*@            '$':'$ : ;       '$':'$ : ; 4  9%   %%:< ).2) )/';% F% %"% %(66-% 6%$% 6 % A  .'  '% % H 9 % '%  (  '% '% >20)0@   ;   9  #  ' .       4      %  %  >  ,//.,1*. an. )+ ' "% % >200)@ .              %  %$   $ % %; 22+.288 )J;%%=6%"%  6 % >2000@$     .      '80  '+0    #     .       &          4  %' % % %@ 200*.20)J. dM. )* (  '% '%  5% % >20)0@ = '$+0   & ;            % %% %   %:: /+*./*2 20 (  '% '% ' ;% - % ;% ( 9  '% =  % %   5% %  %5%%'  #H%5%>200*@         6  %  %%:< )0/.))). pte. 2)(  %"%"#<# %' ;%M <%>200)@..)'  '80    '+0'*0   # # .   /,%5A;%;  12*+.1,0/ 22H6 % % 6  %#%$%% $% %" '% -   %" !%%"  %H<%=;%% 9=%;%'  % %>200+@   "   S 2%0%   %;> 2*8+.2*8J. ce. 2,H =%%$%  %(   %6 %   ;% 6 % >)***@        +0  9 ; % $% % % %%% @9 /8/2./8/+ 28 H<.  $% $  %    5% % >)**J@ = 9        =$      +0.6   6    >'+0@   9  .     %$% % % %%% @? )/2/,.)/2/J. Ac. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. )1 ' ;% - % ;%  " % %  (  '% '% >200+@     .        #   .        % ;%  %%;=; ,8,,8.,8,8/. 2/    % % ( %   A%  (  '% '% >)***@ '  6    >'@80    9 '+0   %;%  %%;< ,1+/+.,1+1,. . Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited. .

(17) Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. 21   % %(%(  %"%A  6(% A%( '%'% >)**+@'+0'80             %;%  %%;; ,,2J,.,,2J*. us cri pt. 2+    % %   -%=% (  %"% (  '% '%   A% >)**/@ = 9      .     4     %  9 <           %5 %;% %;>< ,J2.,J* 2J    B% '  ;% A  6 (%  '  % % >)**1@       .6    +0    9   ;  '80%;%  %% ;:  )*1)+. )*128. an. ,0 5% %  ;% %;%( '%'%    % !% >2000@ )              '+0    %  %   % ;  )0J,. )0JJ ,) 5%   %  '  # H% >200J@ '+0T  '+2   4        9     %54% %. dM. ,2 5%;%   %  '  #H% 5% >200J@   4   '+0T      9     %  %%:> )0/.))0 ,,5%;%$ % %  %'  #H%5%>200+@'+0T     %  %%:; 2)*.22*. pte. ,85%;%$ % %  %;%  %'  #H%5%>200+@   9.      '+0T 4 &     4     % ;% $  ;: 20).2)) ,/ $ % % >)**1@ =- #&                 % %  %  %:; ,/+.,/J ,1  F % % (  '% '%    % % >200+@          9 '+0 %54% %>:> ,/1J.,/+J.  . ce. ,+ %  5% %>200+@  #6     ;       %$% % % %%% :< +)1,.+)1J ,J9 %  %$  5% 6#6%M < % #6 "%( < 6  ;%  % $   % H  % ' ;% =  5%   H% = %    % >200J@ =   'A.                   # '*0 )% 5H %?=; )+JJ.)+*8. Ac. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. 2* 5% %  ;% % '%"9H% % ( '%'%>)***@!      6   +0   % %   %:@ 201*. 20+*. ,*  '% H=% '  % %   6 % >)**,@ ( ; 5     9    .    %5A;%:;  8),+.8)88. . Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited. .

(18) Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. 80-%;% M F   %$%  %  9 A% % (  '% '% >20)0@     6         % % )0).)0,. us cri pt. 8)-%;%M F  %$%(%".-% %  5%%A  . ' '%%% 9A%%( '%'%>20)0@'$+      ?   #    '$   %' % % %:@  81++.81*, 82" %(  % 6#6%"#<#% H%(  %"%' #6 % ;% M < %  M < % >2008@ '*0 # .  /,     %;%  %%;@ 8JJ,1.8JJ8/. ce. pte. dM. an. 88" 6;%%'%B%. B% $ '%H%  %% >)***@        .         9     '$+0% % %;> 82/.82J  . Ac. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. 8," %A <#6 %% 6#6%' #6 %M <%M < %>200*@ '+0  C    /,        %A;= 82J8.82*8. . Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited. .

(19) Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. 4/4 . ce. pte. dM. an. us cri pt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c. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. . . Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited. .

(20) ce. pte. dM. an. us cri pt.  #    #     -/.  #  ,0              % H  . $#      . $ 9%.4 #     . -/ 9% $>9  @ #    %  !?"&!2023%$!$1!30--00!3!0$!1$7)$!01!&107010 323%&%&,-30! ;>&%%0" > @ H     # .   #      $>  @        -/  %   #    ,0     8/ N                ,+ N  2        #  %H    #            % >@          4   $.'?+8   #     -/ % # 8J    %    .    #    .   9  9 #    . $  9% >@   <     #                    %  ! 9"  9 0,3+0 3 &1!#!1) 3 !1, 1, 01!%1!3 32 23%$! 3 3 1, 0--00!3321!3$0-!1,#!2&1!3%070117!$!$3!" > @ $          '$ )   '$ 1      S2% $     9     % >@   -*)!$ !     '$ ) '$ 1  % >@      '$ ) .'$ 1'$ 1.'$ )            %   4   . $      >  @ #   8, N # 9  2        ,+ N% H     #            % >@      '$ ) .'$ 1'$ 1.'$ )               '5(.2*,        '$ ) :%   4   . $#  8/N #92    ,+N%H    #            % >5@     '$ )   '$ 1                   .     % #  #         . 6 8/N,0       %4  #       %  28   9  # 6   8/N ,0       %    2       ,+ N  #        #  % =       #               % > @5 '$ ) '$ 1  9 64 9        .         % #  #           >  @. 6 8/N ,0       %  28   9  # 6 8/N ,0       %    2       ,+ N  #        #  % =       #               % ! 5  $> #9  @ #    %  !" 31, :$ 97!$1,0-%1,332-31!0"  4 '  '$ ) '$ 1  #     -/  ; 9#    #  .= 9%54 9  ;   #    #   .-/  9 %  ; 4    #        . Ac. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. . Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited. .

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(22) Biochemical Journal Immediate Publication. Published on 14 Jan 2011 as manuscript BJ20101247. Figure 1 A unicellular eukaryotes. compartmentalization multi-domain proteins. 15. 80. 5. 60 40 20. S. cerevisiae C. elegans D. melanogaster H. sapiens A. thaliana. Eubacteria. Eukaryota. Archaea. Eubacteria. Eukaryota. an. S. aureus M. pneumoniae E. coli Y. pestis angola. Archaea. Ac. ce. pte. dM. T. kodakaraensis M. jannaschii T. acidophilum M. mazei. 0. S. cerevisiae C. elegans D. melanogaster H. sapiens A. thaliana. 10. DNAJ. S. aureus M. pneumoniae E. coli Y. pestis angola. Number of genes. 100. us cri pt. C. 20. 0. THIS IS NOT THE VERSION OF RECORD - see doi:10.1042/BJ20101247. multi cellularity cellular specialization development. DNAK/HSPA. Number of genes. B. multicellular eukaryotes. T. kodakaraensis M. jannaschii T. acidophilum M. mazei. prokaryotes. Licenced copy. Copying is not permitted, except with prior permission and as allowed by law. © 2011 The Authors Journal compilation © 2011 Portland Press Limited.

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