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Complex Chromatin Motions for DNA Repair

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Academic year: 2021

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FIGURE 1 | Examples of damage-induced changes in chromatin dynamics. (A) A damaged chromatin site explores a larger nuclear volume during HR repair of DSBs
FIGURE 2 | MSD curves identify different types of motions. (A) Illustration of Brownian, anomalous, confined and directed motions, with corresponding MSD curves.
FIGURE 3 | Simulation of confined motion, directed motion and mixed trajectories. The motion of a particle in a sphere of 1 µ m radius was simulated using 1,000 iterations (Bacher et al., 2004; Masedunskas et al., 2017)
FIGURE 4 | (A) Illustration of examples of mixed trajectories. Left: in Drosophila cells, the motion of DSBs leaving the heterochromatin domain and reaching the nuclear periphery is characterized by: (1) confined diffusion inside the heterochromatin domain

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