TABLE OF CONTENTS
ABSTRACT ………….……….………... p.3 ABBREVIATIONS………..…...p.4
INTRODUCTION……….….………... p.5-24
I. NO synthesis and biological functions………...p.6-9 II. Measurement of FENO……….…...… p.10-17 II-1. NO in upper airways………...……...p.10 II-2. NO in lower airways………...p.11-13 II-3. Detection of exhaled NO ………...p.13-14
III. Exhaled nitric oxide levels in healthy status and atopic diseases………... p.18-19 IV. Exhaled nitric oxide production in asthma………... p.20-24 IV-1. Immunological considerations………...……….p.20-21 IV-2. Anatomical considerations………..p.22-24
AIMS AND PRESENTATION OF THE STUDIES PERFORMED IN THE SETTING OF THIS PhD WORK……….…...p.25-44
PART 1: Origin of NO production associated with allergen exposure in asthma
Haccuria A, Michils A, Michiels S, Van Muylem A. Exhaled nitric oxide: A biomarker integrating both lung function and airway inflammation changes. J Allergy Clin Immunol 2014;134:554-9 ... …...attached article + p.26-27 PART 2: Origin of NO production in allergic rhinitis
Haccuria A, Van Muylem A, Malinovschi A, Doan V, Michils A. Small airways dysfunction: the link between allergic rhinitis and allergic asthma. Eur Respir J 2018;51(2)………...…attached article+ p.28 PART 3: FENO being produced by epithelial cells, is there a link between the epithelial-driven cytokine IL- 33, with FENO increase in asthma and rhinitis?
Haccuria A, Van Muylem A, Raschaert J, Virreira M, Gaspard N, Bruffaerts N, Michils A. Increased production of the IL-33 epithelium-derived alarmin in the lower airways of allergic rhinitis patients and relation to natural pollen exposure. Manuscript in preparation. ………..………...p.29-44
GENERAL CONCLUSIONS………..………..…….... p.46-48 REFERENCES……….………….………..…... p.49-56
