• Aucun résultat trouvé

Klebsielle Pneumoniae pathogène nosocomial, résistance et virulence

N/A
N/A
Protected

Academic year: 2021

Partager "Klebsielle Pneumoniae pathogène nosocomial, résistance et virulence"

Copied!
191
0
0

Texte intégral

(1)

HAL Id: tel-00831671

https://tel.archives-ouvertes.fr/tel-00831671

Submitted on 7 Jun 2013

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Klebsielle Pneumoniae pathogène nosocomial, résistance

et virulence

Najiby Kassis-Chikhani

To cite this version:

Najiby Kassis-Chikhani. Klebsielle Pneumoniae pathogène nosocomial, résistance et virulence. Mi-crobiologie et Parasitologie. Université Pierre et Marie Curie - Paris VI, 2012. Français. �NNT : 2012PA066093�. �tel-00831671�

(2)

THESE DE DOCTORAT DE

L’UNIVERSITE PIERRE ET MARIE CURIE PARIS 6 1

1

1

ECOLE DOCTORALE : COMPLEXITE DU VIVANT (515) Spécialité: MICROBIOLOGIE

Présentée par

Najiby KASSIS-CHIKHANI Pour l’obtention du grade de

DOCTEUR DE L’UNIVERSITE PIERRE ET MARIE CURIE Titre de la thèse : 1

KLEBSIELLA PNEUMONIAE

PATHOGENE NOSOCOMIAL

RESISTANCE ET VIRULENCE

1 1 Soutenue le 21 mars 2012 1 1

Devant le jury composé de :

1

1

Monsieur le Professeur Vincent JARLIER Président

Monsieur le Professeur Antoine ANDREMONT

1

Rapporteur1

Monsieur le Professeur Jean-Louis GAILLARD

1

Rapporteur1

Monsieur le Docteur Jean-Ralph ZAHAR

1

Examinateur1

Monsieur le Professeur Guillaume ARLET Directeur

Madame le Docteur Dominique DECRE1 Co-directeur

1

(3)

23432563437891 1

1234256274896AA6B42CD45E642

234156178491ABCDEE63F161F46F1699619C61A1819D3D3F191B3E1F8E1D3946E1 1 477F6E961 F4D61 8F7D41 47744A61 61 581 461 FD764DEE6AA61 691 61 A341 6E1 341 69F5656E91F6DEE848E961

1

1234256274896AA6B421F468F2

2341 81 8691 61 DE8F6F1 31 9651 1 AB8A3894DE1 61 5DE1 58E3F491 2341 5B81 8364AA4616E8E9118E1D5561 498E96!"D498AD#$E46F4984F618E1DE1A8%DF89D4F611 ABC&498A1'4C89169115B81D36F911A61D46161A81'89F4DAD46169161AB"(4E61

1

1234256274896AA6B42DE55D422

2341D3F1A816345617D41818691B9F615DE1F8DF963F)1*A81F654F617D41D3F1 5DE1 D961 61 +"1 1 ABC&498A1 +83A1 'FD36,1 691 81 8691 61 DE8F6F1 31 9651 1 AB8A3894DE1615DE158E3F49111 1 1234256286B42DD42 1 2341818691B6854E6F1619F884A161A3416E13419F1F6DEE848E9611 1 1234256274896AA6B4214562

2341 81 4FF41 61 9F884A1 A1 5B81 4E4961 1 6E9F6F6EF61 61 9F884A1 691 9D3D3F1 6ED3F861 -61 A61 F656F461 D3F1 81 84DE1 DE1 6E9CD348561 81 3A93F61 46E94742361 23B4A1849141%46E19F8E5699F6119D3961AB23461.B691D3F15D413E1F8E1A844F1619F884AA6F1 861A341

1

1236256286B42642

2341 81 4FF41 61 9F884A1 861 D596E61 691 F4363F1 -61 A81 F656F461 D3F1 DE1 D3946E1814DE4%4A4916913F9D391DE185494123415B69141F463611

1

1236256274896AA6B42BAADE2

1581 /1.C467101 2341 5B81 8364AA461 8E1 DE1 A8%DF89D4F61 61 14FD%4DAD461 1 ABC&48A1 +83A1 'FD361 -61 A81 F656F461 D3F1 81 DE748E61 DE1 D3946E1 61 6ED3F8656E91 DE1 877694DE1

1

128F2BE62

1.89C(1 'D396A46F1 .CF4948E61 23F4E1 .CF4948E1 36E6A4E1 .A4E61 +69694E1 D3F1 A63F1 D3946E1A63F18461A63F1DAA8%DF894DE1 1 128B625BE62B25D8D4D8E462623E48E858E62625ED527DB52 48BAA622 D3F1A63F18461691A63F1DAA8%DF894DE1 1 128BA256A264A8FF65A2B2!" 2 12341DE9161DAA8%DF8963F16694DEE6A1 1

12 8B62 5BE62 B2 5D84D8E462 62 D4E858E62 62 5D2 #DB52 62 36EF62 62 $DEF%1F8EF622

6E1 8F943A46F1 '89F461 46AC4E61 691 589C8A461 D3F1 A63F1 8364A1 C8A63F631 691 A63F1 8461F46361 1 126A2D46FA2 D3F1A63F1D3946E16E8E9161ADE3618EE61 1 123E65262!D456A22 1 D3F1A63F1F6E611561&91A63F16ED3F8656E91691A63F18946E61)1

(4)

239A431 1

48E1 A81 F654F61 8F9461 31 9F884A1 34961 1 631 45461 1 123 4567895AB63 FD39F461 61 8F%8E5861 ED31 8DE1 74E41 3E61 9F89461 F4612341 ED31 81 6F541 61 5869F46F1 691 61 9D6F1 A81 F654F61 45461 691 61 9F1 F84656E91DE9F&A6F1A816DE61461563F61454A84F61DE91918A42361861 318E1B839F61C&498316E17F8E616E1F88A1691831$3 11

.61 631 45461 98E91 A461 1 A81 47734DE1 61 ADE61 4542361 ED31 8DE1 9341A81F8A6E616178963F1614F3A6E618F5413E61DAA694DE14E96FE894DE8A61 61D3C61611234567895AB6153A94F498E9618318E94%4D94236115D318DE131 98%A4F1 3E1 A46E1 6E9F61 F498E61 691 4F3A6E61 861 6E1 8F943A46F1 3E61 7DF961 F8A6E61*9:,1B3E16AD916189CDE4491DF98E91A81(6F4E48%894E61;%912341 D36166E946A18E1AB6F64DE131CED9(61C(6F#4F3A6E9161C6DEA5AB111 48E1 A81 634561 8F9461 ED31 5DE9FDE1 2361 A61 D3C61 61 123 4567895AB61 FD39F461 61 '<3=1 61 9(61 .>?#1#@A1 DE91 8D461 1 61 A85461 88F96E8E91831FD361B4ED5894%4A491E718ADF12361A61A85461DF98E91A61 E61FB3"B1691631DF98E91A618F%8E5861DE915D4E1%46E18F89F41691 D36E91 EDE1 9(8%A61 8F1 A81 59CD61 61 +.C1 .61 F3A9891 4E496E91 831 236ED86161A85461

5D31 8DE1 FD1 831 1 1 236ED861 691 1 AB8EED9894DE1 31 F6546F1 A85461 DF98E91 1 A81 7D41 E+.#91 691 3"B#@91 4DA1 B3E61 D3C61 61 123 4567895AB61 .69961 8E8A(61 ED31 81 6F541 61 5699F61 6E1 46E61 3E1 ED36831 FD361 B4ED5894%4A491 *E?,1 45A4231 D3F1 A81 F654F61 7D41 8E1 A81 53A94F498E61 C6F1 123 4567895AB61 5D31 8DE1 31 1 5DE9F6F1 AB4E6F94DE1 31 9F8EDDE1>E3 *E+.,183164E1319F8EDDE1DF98E91A81'<3=1619(613"B#@91

1

4BCD1 EFDG1 16EA6B3 4567895AB61 45461 563F61 61 DE9F&A61 4A&91 61 89CDE4491FA4DE1A85461236ED86111 1 1 BCB11ECBFB1 EFC114E19CCB1 ADC1 D1!1 1C1415

(5)

868831"11 &'( $)(''127*(+3,*)1(2 7#9#5#461 8$#%371 23969875317&1'62A37531 1 982581 1

E1 9C61 74F91 8F91 D71 D3F1 HDFI1 7DAADH4E1 9HD1 D39%F68I1 9C891 4EDA61 123

4567895AB61FD34E18F%86E65861H61674E6181A68F19F896(19C8918AADH61

31 9D1 DE9FDA1 8E1 9D1 9C61 F681D71 9CD61 9F84E1 3454A8F1 5683F61 C861 %66E1 8A461 3673AA(1 4E1 D9C6F1 CD498A1 4E1 7F8E61 F86A1 8E1 9C61 $E4961 3989611 >C6619HD1D39%F68I1A4EI619D19C61F681D71646541ADE61A61319D193(19C61 F68A6E61 D71 4F3A6E61 789DF1 85DE1 8E1 4E96FE894DE8A1 DAA694DE1 D71 53A94F3# F6498E91 123 4567895AB61 9F84E1 J61 D3A1 698%A4C1 81 A4EI1 %69H66E1 F6498E61 8E14F3A6E61H49C16648AA(181C4C1F68A6E61*9:,1D718189CD6E449(14A8E1 %68F4E1 9C61 (6F4E48%894E1 ;%91 HC4C1 A8(1 8E1 66E948A1 FDA61 4E1 9C61 6F64DE1 D71C(6F#4F3A6E91C6ED9(61D71C6DEA5AB111

E1 9C61 6DE1 8F91 D71 D3F1 HDFI1 H61 CDH61 9C891 9F84E1 D71 123 4567895AB61 FD34E1 .>?#1#@A1 9(61 =3'<1 8F61 8D48961 H49C1 A8541 %6ADE4E1 9D1 4ED5894%4A49(1 FD31 E71 HC6F681 A8541 8FF(4E1 FB3"B1 6E61 8E111 8F%86E65861 8F61 A61 H6AA1 C8F896F4F61 %(1 9C61 +.C1 569CD1 >C661 F63A91 A6819D19C616236E4E1D71A85411

J61F6DF919C61D5A6961E3A6D94616236E61D719C6174F91E?1A85418FF(4E181

FBE+.#916E617FD5116FEA6B2391DE491D719C61%8I%DE61D719C61E?1A85418E1 8FF461 81 F64DE1 6ED4E1 %D9C1 E+.#91 8E1 3"B#@91 1 >C61 9F8EDDE1 >E1 41 4E6F9614E1818F916ED4E19C61FB3"B#@91

1

()1 *BDG1 16FEA6B3 4567895AB61 D39%F68I1 DE9FDA1 5683F61 F6A4DE1 A8541A85416236E6189CD6E449(14A8E1

1

BCB11ECBFB1

EFC114E19CCB1 ADC1 D1!1 1C14151

(6)

1

239A431381 329 3586'391

48E1 A81 F654F61 8F9461 61 ED9F61 9F884A1 1 A81 34961 61 631 45461 1 123

4567895AB63 FD39F461 61 8F%8E5861 ED31 8DE1 74E41 3E61 9F89461

F461 2341 F6D61 3F1 A61 F6F861 61 8946E91 1 F42361 A81 5461 6E1 A861 691 A61 584E946E1 61 F8394DE1 DE9891 AB4DA656E91 DF8C42361 A61 49861 691 ABDF8E4894DE161D4E1A817DF5894DE1316FDEE6A16916E74E16E1F6E61B3E181 6DE84F61 A81 5461 6E1 A861 31 DCDF94E1 691 31 6FDEE6A1 41 .61 563F61 ED31 DE91 6F541 61 5869F46F1 691 61 9D6F1 A81 F654F61 45461 691 61 9F1 F84656E91DE9F&A6F1A816DE61461563F61454A84F61DE91918A42361861 318E1B839F61C&498316E17F8E616918A656E916E18F943A46F16E1F88A1691 831$3 1

.61 631 45461 98E91 A461 1 A81 47734DE1 61 ADE61 4542361 ED31 8DE1 D3A31 9346F1 A81 F8A6E61 61 78963F1 61 4F3A6E61 *D31 61 3F461 831 9F6,1 8F5413E61DAA694DE14E96FE894DE8A6161D3C61611234567895AB61FD39F46161

β#A8985861 DE7F8E91 A81 F498E61 831 C8ADDF4E61 691 8F7D41 831 8F%8E561691DE916F984E61DE9191F6DE8%A61B45461.619F884A1691 A61F6546F1198%A4F13E1A46E16E9F61F498E616914F3A6E618616E18F943A46F13E61 7DF961 F8A6E61 *9:,1 B3E1 6AD91 61 89CDE4491 DF98E91 A81 (6F4E48%894E61 ;%91 2341 D361 66E946A1 8E1 AB6F64DE1 31 CED9(61 C(6F#4F3A6E91 61

C6DEA5AB111

1

48E1 A81 634561 8F9461 61 ED9F61 9F884A1 ED31 5DE9FDE1 2361 A61 D3C61 61123

4567895AB61 FD39F461 61 '<3=1 61 9(61 .>?#1#@A1 DE91 8D461 1 61

A85461 88F96E8E91 831 FD361 B4ED5894%4A491 E71 A85461 2341 F46E91 C6F11234567895AB61691234161A31DF96E913E1D4F61631(956161584E946E1 D31 (9561 B8494DE1 61 9(61 9D4E6#8E949D4E61 =E1 F68EC61 A61 A85461 DF98E91 A61 E61 FB3"B1 691 631 DF98E91 A61 8F%8E5861 DE91 5D4E1 %46E1 8F89F41 691 D36E91 EDE1 9(8%A61 8F1 A81 59CD61 61 +.C1 .61 F3A9891 4E496E91 1 AB8E8A(61 A31 D5A961 61 A85461 6E1 8F943A46F1 FK61 831 236ED861

5D31 8DE1 236E6F1 A61 F6546F1 A85461 DF98E91 1 A81 7D41 E+.#91 691 3"B#@911 4DA1 B3E61 D3C61 61 123 4567895AB61 F6DE8%A61 B3E61 45461 8E1 ED9F61 C&498A1.699618E8A(61ED31816F541615699F616E146E613E1ED36831FD361 B4ED5894%4A491 *E?,1 45A4231 D3F1 A81 F654F61 7D41 8E1 A81 53A94F498E61 C6F11234567895AB615D318DE1318A656E915DE9F6F1AB4E6F94DE1319F8EDDE1 E+.1*5L@,183164E1319F8EDDE1DF98E91A81'<3=1619(613"B#@91.619F884A1 DE74F561DE1A618849145DF98E961619F8ED494DE1319F8EDDE1E+.1 <61 6F69461 61 61 9F884A1 DE91 *4,1 A61 236ED861 61 A81 F4DE1 D5F6E8E91 AB"+1691A61(956161F94DE1619(61B1691A81F6C6FC61B3E16E936A1(9561 615D%4A4894DE18E1ED1ML1D3C6153A93F498E961D8E911A817D41AB"+1691 A61E61AD1*44,1 AB936161A814F3A6E616161D3C618E13E15DA618E458A1 B4E7694DE186161D3C618616918E1(6F4E48%894E61874E161F46F1A61F&A61 61A81(6F4E48%894E618E1AB4E7694DE111234567895AB611

1 5D(6E1 96F561 A1 ED31 8F8491 4E46E8%A61 61 54631 8F89F46F1 A61 D3C61 F6DE8%A61 B45461 61 96F54E6F1 A63F1 8F89F61 61 4F3A6E61 61 236E6F1 A61 A85461 691 A61 ED561 A1 783F81 46556E91 8A36F1 61 E61 8E4891 8F1 61 9361 A53 AD91 691 C6F1 AB8E458A1 61 2341 ED31 4E496F81 1 6AD6F16EDF61B839F61DAA8%DF894DE1

(7)

831&39148632391

1

8

82'6166#%2 $6+A31

9 6,D-.E1&-F6B8FED6 9 @#2EF8A49 9 9#1"8%49891691D3D4F189CDE6 9 M#31234567895AB6169145461CD498A4F61 11 #119CD61619(861 1 12 66ECD11FE11&-2F6B8FED62 1 13 @#1 E94E61613F7861 13 9#1 C4E61 17 M#134FDCDF61 19 #1NAD916189CDE4491 23 A#1E96F894618E1.DE389461=A656E91*.=,1 25 O#1 39F61E61614F3A6E61 1 31 66612DDCE11&-2F6B8FED61/1CBC0D1 1 32 @#136E4%4A491E893F6AA61611234567895AB61 32 9#1C498E61823461611234567895AB61 1 33 6'12--F1D1FD11ED1D1,ECB1C11DDCE1 /1ββββFEC1D1 1 34 @#12EF8A491 34 9#1C498E61831β#A89854E61 34 M#1.A8474894DE1691DA394DE161β#A8985861 37 81.A8474894DE161β#A8985861 37 %1<61β#A8985861169F6196E31 40 1<61C8ADDF4E861823461 46 1<618F%8E5861 47 6113A94F498E6161D3C61611234567895AB63 1 53 '19--BCD1C0D11F1DDCE1 1 54 @#1+A86161A85461 55 812EF8A491 55 %1+A8546G1FA4894DE1691DE9F&A61 56 1+A8546G1ED5%F6161D4614ED5894%4A491A8474894DE1 56 1+A8546G17DE94DE161584E946E1 57 61+A85461G15D%4A491 59 9#1<61236E61B4E6F94DE1 61 M#1<61A56E919F8ED8%A61 62 #1<614E9FDE1 1 63

(8)

1 '61D1F1CD1C0D1DDBED1/1931C1 E-1DD211-CEFD1E341&-2F6B8FED62 1 65 '6612-FEBD1C1-FD1D1D0ED11&-2 F6B8FED61 71 1

82'61 329#7731

75 #5EC6D11CF1 1 76 FECB178G1=96E615683F617DF1DE9FDAA4E18E1 D39%F68I1D71B1#@1FD34E14546E65#F6498E9116FEA6B1 4567895AB63A53B3A6D3DB5E4B5365D63A53DB56321 1 79 FECB179G1P39%F68I1D7116FEA6B34567895AB61 FD34E1E+.#918E13"B#@914E1817F6EC1CD498A1 1 95 FECB17:"1*6E1D3F161F894DE,G1P3FF6E61D71 4F3A6E61789DF1C4C189CD6E449(14A8E18E1.=414E1 A4E48A14DA8961D7153A94#F3116FEA6B34567895AB1 1 105 FECB17;"1*D3546,1C6A4DE18E19C64F18494DE1 (96514E116FEA6B34567895AB613694%A61DF1F6498E919D1 %FD8#69F3516C8ADDF4E18EQDF18F%86E651 1 114 FECB17<"1*6E1D3F161F894DE,G1.D5A6961 E3A6D94616236E61D71E+.#918E13"B#@916ED4E A8541 E3RL17FD5116FEA6B34567895AB61 1 144 &695A996#71381 329 3586'391 1 154 233237539166#%2 $6+A391 1 161 773=391 190 1 1 1 1 1 1 1 1 1 1 1

(9)

1

1

1

1

1

1

1

1

1

82'6166#%2 $6+A3

(10)

6782#&A586#71

1

6,D-.E1&56AE655D2F6B8FED61

8%FCD1

4B3E1 D4E91 61 361 98DED542361 A61 6EF61 8936A1 16FEA6B1 D5F6E1 91 661F4E48A6G11234567895AB61*3%44616E1M1D3#66,16911123 9 9B1 <61 8E46EE61 661 98DED542361 123 D!A59E6D98BAE1 691 123 9"65B61 DE91 61 D3#661 61 123 4567895AB61 691 AB8E8A(61 1<3>1 5DE9F6E91 23B6AA61 F6F6E96E91 61 ADE61 831 64E1 61 AB661 123 4567895AB61 *ML,1 =E74E1 B8D396E91 123 #DB5798BAE1 86E91 61 A81 DED8ED61 84E41 2361 91 98DE1 F6556E91 4E4438A41 *123 BDAA9B1 691 123EA5#B49D65EAE,1*@9,1

16FEA6B3 4567895AB61 691 3E61 6E9FD%89F461 88F96E8E91 831 6EF61 16FEA6B1 A1 B8491 B3E1 %84AA61 1 2F851 E89471 9D3D3F1 455D%4A61 691 9F1 D36E91 83A1 D38E91 3F1 54A4631 DF4E84F61 6E1 895DCF61 8FD# 8E8FD%461 D(861 E89461 1 76F56E98E91 A61 A3D61 691 A61 A89D61 6E1 FD348E91 31 8F1 FD348E91 61 AB4EDA61 691 3E61 3F861 691 76F56E98E91 AB89DSE61 *F894DE1 61 BD6#+FDI836F,1 F348E91 A61 E49F8961 6E1 E49F4961

1

9$CC1C1-BB1-C3B.1

123 4567895AB61 691 3E61 661 3%4234984F61 =AA61 6391 9F61 4DA61 61 AB6E4FDEE656E91 *DA1 6831 61 3F7861 6831 361 983,1 84E41 2361 61 7ADF61 D556E8A61 61 ABCD5561 691 61 8E45831 *@9,1 =AA61 DADE461 323B1 ML:1 61 4E4431 831 E46831 61 53236361 469461 691 E8DC8F(E61 <81 DADE4894DE1 8356E961 61 78DDE1 9F1 45DF98E961 C6F1 A618946E91CD498A41*OO1@9M,1

123 4567895AB61 691 1 ABDF44E61 B4E7694DE1 D553E83984F61T1 6AA61 81 91 4E4948A656E91F49618E161E635DE461EFD8E961*E635D#%84AA6161 7F46A8E6F,13F6E8E9166E946AA656E913F196FF84E19C(A42361*O,1=AA61691

83D3FBC341 3F9D391 F6DEE361 D5561 F6DE8%A61 B4E7694DE1

(11)

DF89D4F61 6945461 E635DE46,1 =E1 =3FD61 D5561 831 =9891 $E41 6E4FDE1 U:1 61 4E7694DE1 EDDD548A61 DE91 361 1 69961 661 =E1 7F8E61 A61 F8DF91 61 ABP5=C' 1 *P%6F89D4F61 5894DE8A1 61 AB=454DAD461 61 A81 C498E61 '89F46EE61 831 E94%4D94236,1 61 9LLU1 4E42361 2361 123 4567895AB61 691 F6DE8%A61 F6694656E91 61 U:1 691 A:1 61 %89F45461 D553E83984F61 691 EDDD548A61 61 2341 A81 A861 831 M561 F8E1 61 %84AA61 1 2F851 E89471 8F1 $E!6DA!AB3 9A3 691 %E67&9895BE3 B6D7#A59EB23 123 4567895AB61 D361 3E61 A861 45DF98E961 8E1 A81 89CDAD461 4E76946361 31 ED3683#E1 =E1 677691 A61 4E7694DE1 EDDD548A61 1 123 4567895AB61 8E1 A61 6F461 61 EDE89DAD461 DE91 7F236E961 ED98556E91 8E1 A61 3E491 61 D4E1 4E96E471 691 C6F1 A61 F5893F1*@V1@@M,11

<61 DE9F&A61 61 4E7694DE1 EDDD548A61 1 121 4567895AB61 F6D61 W3E61 8F91 3F1 A81 5869F461 61 A63F1 9F8E544DE1 *F6691 61 563F61 BC(4E61 A842361 A8861 61 584E1 4DA656E91 DF8C42361 691 96CE42361 61 8946E91DF963F1F669161FD9DDA6161D4E16189C96F13F4E84F61 691 64E631 61 9F8CD9D5461 61 A8461 691 61 AB234656E91 CD498A46F,1 *M@,1 691 B839F61 8F91 3F1 A81 5869F461 61 A81 F6F494DE1 61 8E94%4D942361 184161DE9F&A61E6163919F6167748618E13E61DEE848E618FD7DE461 61 88491 61 4F3A6E61 691 61 9F8E544%4A491 61 477F6E91 4DA891 1 AB4E9F463F161AW6611214567895AB621

=E74E1 6341 A61 8EE61 UL1 123 4567895AB61 81 56F1 D5561 86E91 B8%1 C8942361 F4549471 3F6E8E91 8E1 A81 D553E8391 C6F1 61 8946E91 8E1 8E96E91 61 89CDAD461 C89D%4A484F61 *@RV,1 .61 (EFD5618D4113E61%89F454616916E936AA656E9161D5A4894DE1 59898942361 *6EDC98A5461 5E4E4961 ),1 81 91 66E946AA656E91 F491 6E1 4611 *AA1 RO1 9V@,1 +A31 F6556E91 61 81 DE91 91 F8DF91 6E1 5F42361 31 5DF1 691 6E1 =3FD61 *@LL1 9AO1 U@,1 D36E91 C6F1 8946E91 BDF44E61 848942361 3F8E91 3E61 3694%4A491 E942361 1 69961 4E7694DE148E1A8158DF4916181A61D3C611ABDF44E616161(EFD561 88F946EE6E91 831 FD9(61 83A84F61 E@1 691 831 D5A661 ADE8A1 3>9M1 *9AO,14B839F61FD9(61*E91EA1691EAV,1DE91A31F8F656E91F6EDE9F1

(12)

8E1 61 (EFD561 461 D3C61 61 FD9(61 E91 88F96E8E91 1 61 3>1 56F6E91 *3>UO1 3>MUL,1 DE91 8A656E91 91 F8DF961 8E1 61 4E7694DE1F61*U@,1=E1=3FD616916E1 5F4236131EDF1A61FD9(61E91 88F8491 86F1 7F236556E91 *A1 1 9L1 :,1 8F541 A61 4E7694DE1 EDDD548A61=E1F68EC61A61FD9(61E@1EB(169181D%6F16E16CDF1 618%1317D461*9UV19AO,1

1

:&-2F6B8FED61C1-1D13BD-CF.D1

123 4567895AB61 691 A81 F4E48A61 661 %89F46EE61 F6DE8%A61 B45461 4E9F8#CD498A4F61 46341 8E46F1 9LLO1 8961 61 ED9F61 F654F61 3%A4894DE1 3F1 61 3691 *@MR,1 ED31 8DE1 8E8A(1 UA1 3%A4894DE16F49461F7F6E618E1+3%1616E1988E91A615D91A1 /1IA6%46AA81 E635DE4861 8E1 EDDD548A1 D39%F68I*,01 >D3961 61 3%A4894DE1F6A896E916145461361161D3C6153A94F498E961691 FD39F46161ED36AA61β#A8985861<618(1DE6FE1DE91F8F941 3F1 A61 A1 DE94E6E91 861 3E61 784%A61 F6F6E9894DE1 61 8(1 6E1 D461 61 6AD656E91 6E1 F84DE1 61 AB4E37748E61 61 5D(6E1 C3584E1 96CE42361691%4DAD42361D3F13%A46F18E161F63614E96FE894DE8A611 <618(1A61A31DE6FE18F161FD%A561DE91G1A61=9891$E41*EX@@1 3%A4894DE,1 A81 2F61 *EX@L,1 =8E61 *EXR,1 5F42361 31 31 *EXR,1 98A461 691 A81 7F8E61 *EXV,1 F88A1 *EX,1 DF61 *EXM,1 .C4E61 *EX9,1 <61 ED5%F61 61 81 F8DF91 8F1 45461 8F461 61 91 1 @O@1 48E1 9A:1 61 81A616F461DE6FE1DE91613E49161D4E14E96E47183A961D3161 EDE89DAD4611

<61 F4E48A61 β#A8985861 8D461 1 61 ADE61 4542361 DE91

66E946AA656E91618F%8E5861*EXAL,1*E+.1B11P? #U,161β#

A8985861 1 69F61 96E31 *EXMO,1 *.>?#1#@A1 3"B#@9,1 61 5.1 *EXA,1 *4" ,1 .6F984E1 ADE61 74E41 8F1 '7A97E3 E6(76563  4A5#11 *1<3>,1DE9191F8DF918D4116F984E61β#A89858616E18F943A46F1 3>9AU1 *36236E61 >(6,1 691 E+.#M1 D5A661 ADE8A1 *..,1 3>@@1 3>@A1 3>V1691.>?#1#@A13>@L@13>MRA1691P? #U1

(13)

Y389F616E23961E894DE8A61DE91F8DF91A8147734DE161ADE614542361 *4,1 6E1 "DEF461 861 3E1 ADE61 FD348E91 .>?#1#@A1 *@RO1 81 8E1 @1 C&4983,1 *44,1 6E1 2F61 861 3E1 ADE61 FD348E91 B1#@1 *L1 C&49831 9L:1 61 4DA891 61 123 4567895AB6,1 *444,1 6E1 2F61 861 3E1 ADE61 FD348E91E+.#91*@OO1818E11C&4983,1*4,16E1F88A18613E1ADE61 FD348E91E+.#M1*@9VA1818E19V1C&4983,11

1

;4C3BD11C)-1

431D4E9161361454DAD42361477F6E96159CD61DE9191FDD61 D3F1 D58F6F1 A61 D3C61 61 123 4567895AB61 +8F541 A61 59CD61 CED9(42361 A61 FD9(861 %81 3F1 A81 96F54E894DE1 61 AB8E94E61 83A84F61 E1 691 47744A656E91 8A48%A61G1 VV1 FD9(61 83A84F61 DE91 8936AA656E91F6DEE31$E6159CD618F1+.C#C7<+18191F4961*9R,1 +8F541A6159CD615DA3A84F61A61F4%D9(8616919F14F454E8E91D3F1 A61 4DA891 61 123 4567895AB61 <BA69FDCDF61 6E1 C851 3A1 691 3E61 96CE42361 61 F7F6E61 F6FD394%A61 691 4F454E8E961 5841 F6A894656E91 ADE361 <61 96CE42361 B85A474894DE1 8A89D4F61 *C +41 =C.#+.C,1 DE91 784A6115699F616E1Z3F6158415D4E14F454E8E961T16AA61636E919F61 E8E5D4E1889611AB454DAD461AD8A61*VR,1

=E74E1 1 A61 1<3>1 2341 DE4961 1 85A4746F1 691 236E6F1 A3463F1 E61 61 5E861 691 F6FD394%A61 691 6F5691 61 D58F6F1 61 D3C61 6E9F61 A8%DF89D4F61 <61 C581 1<3>1 6AD1 8F1 448D3F91 63 B1 %81 3F1 V1 E61 691 8936AA656E91 A61 A31 394A41 *UA,1 A1 81 6F541 ED98556E91 61 5699F61 6E1 46E61 A81 47734DE1 31 ADE61 3>9M1 8E1A61 8%1 C8942361 56F6E91 <61 9F884A1 F6E91 61 'F461 63 B1 81 5DE9F1 AB6496E61 61 D5A661 ADE831 8D41 1 3E1 D3D4F1 89CDE61 8F943A46F1 8F1 665A61 ..9ME@1 691 ..U9E91 *ML,1 +8F1 84AA63F1 A61 9(861 1<3>1 691 A8F656E91 394A41 8E1 A61 9361 61 ADE8A491 61 D3C61 53A94# F498E961 454E8E91 1 ABC6AA61 5DE48A61 4E41 6F984E1 ADE61 FD3963F161.>?#1#@A1D5561A61ADE613>@@16913>@A165%A6E918D4F1 3E1 C8391 D96E946A1 4542361 A1 6E1 691 61 5561 D3F1 A61 ADE61 3>9AU1

(14)

FD3963F1618F%8E5861619(61E+.1*9MM,123416913E18F48E913F13E1 63A1AD3131ADE613>@@1*VV,1

11

66 ECD11FE11&-2F6B8FED61

<61 96F561 78963F1 61 89CDE4491 691 78963F1 61 4F3A6E61 DE91 D36E91 394A41 D5561 (EDE(561 1841 6F984E1 83963F1 7DE91 3E61 494E94DE1 A84F61 6E9F61 A61 631G1 A61 96F561 89CDE4491 74E491 A81 88491 61 A81 %89F461 1 836F1 3E61 58A8461 8ADF1 2361 A81 4F3A6E61 691 A81 563F61 D31 A61 6F16189CDE4491*9LV,1 .4E219(616178963F1DE9178491ABD%691B9361*743F61@,1 1 1 81"1 C6F6E9894DE1 C58942361 61 78963F1 61 89CDE4491 61 1234567895AB614B8F1+DC3E163B21*9LV,231 8C.D11D6E1 46319(61B8E94E61DE916F4511A813F7861611324567895AB61.61 6318E94E61DE9F4%36E91 1A81 89CDE4616169961%89F461<61F6546F1 691AB8E94E61P12341691D5D8E9131A4D8C8F461*<+3,1691DE91R19(61 DE91 91 46E94741 <61 6DE1 691 AB8E94E61 83A84F61 *E,1 3E1 DA(8C8F46183A84F61DE91U91DE9191F491691VU18F89F41

• <61A4DDA(8C8F461*<+3,1

<61 <+31 691 7DF51 61 A3463F1 D5D1G1 A61 A4461 1 61 9F393F61 DA4D8C8F442361691AB8E94E61P1<B8E94E61P1D5D1A61A31696FE61

(15)

31 <+31 691 7DF51 B3E491 F961 61 DA(5F61 BDA4D8C8F461 A1 64961 3E61 F8E61 8F48%4A491 C4542361 61 A81 D5D494DE1 61 AB8E94E61 P1 F67A69161A818F48%4A491E94236161E6145A42318E1A81(E9C6161 AB8E94E61 P1 691 4931 831 E46831 31 A396F1 )F1 <61 A4461 1 DFF6DE1 1 AB6ED9D4E61 61 %89F461 1 2F851 E89471 691 8F94461 831 D3D4F1 89CDE61 381 A4%F894DE1 58461 8E1 A81 4F3A894DE1 831 D3F1 61 %89F45461DE3491831CD16ED9D4E42361

• <8183A61

<8158DF49161D3C61611234567895AB61FD34913E6183A6161E893F61 DA(8C8F442361T16AA61DEE61831DADE4613F1AD613E6188F6E61A31 D315D4E1532363618F89F4942361*OU,1

33F1 A61 U91 8E94E61 83A84F61 VV1 DE94936E91 3E61 %861 61 F6DEE848E614E96FE894DE8A61<8183A6169166E946AA611A814F3A6E6161 IA6%46AA61 *OU1 UU1 @9O,1 =AA61 7DF561 W841 7846831 61 9F393F61 74%F4AA84F61 D3F8E91 A81 3F7861 %89F46EE61 6E1 D3C61 8461 691 6E61 *M,1 2341 FD961 A81 %89F461 61 A81 C8D(9D61 8F1 A61 DA(E3A84F61 E639FDC4A61W3E618F91*9LA19LO19919M,169161AB677691%89F446161 78963F1 F42361 B839F61 8F91 *9V,1 <61 58E4561 5DA3A84F61 DE496F8491 1 4EC4%6F1 AW894894DE1 D31 AW8%DF94DE1 61 D5D8E91 31

D5A56E91 6E1 8F943A46F1 .M%1 *9VA,1 P39F61 A63F1 7DE94DE1

8E94C8D(984F61 A61 DA(8C8F461 83A84F61 D3FF846E91 4EC4%6F1 A81 477F6E4894DE1 691 A61 88491 7DE94DEE6AA61 61 58FDC861 A53 AD91 *9U19UA,1>D3967D416E196F5616189CDE44914A16496161477F6E61 45DF98E961 6E1 7DE94DE1 61 FD9(61 83A84F61 +A3463F1 5DA61 B4E7694DE1 6F456E98A61 DE91 6F541 61 5699F61 6E1 46E61 61 477F6E61 <61 D3C61 6F458E91 A61 8E94E61 83A84F61 E@1 691 E91 DE91 8F943A4F656E91 4F3A6E961 8E1 3E1 5DA61 53F4E1 61 F49DE4961 D58F61 1 B839F61 FD9(61 2341 DE91 631 D31 814F3A6E91 *R1 @V@,1 48E1 A61 A4DE1 398E61 4E34961 6F456E98A656E91 C6F1 A81 D3F41 A61 D3C61 61 FD9(61 E@1 E91 E1 EA1 61 DE91 FA1 A61 A31 4F3A6E961 *9@,1=E189CDAD461C3584E61556141A61DEE61DE918F6AA84F61A61 D3C61 61 FD9(61 E@1 691 E91 DE91 8936AA656E91 DE4F1 D5561 A61

(16)

A31 4F3A6E961 <61 6F1 61 4F3A6E61 61 A81 83A61 65%A61 DFFA1 861 DE1 DE96E31 6E1 58EED61 =E1 677691 A61 FD9(61 83A84F61 96A1 2361 EV1 D31 E9@1 1 *@RL1 9LO,1 DE946EE6E91 61 236E61 F961 61 58EED6#α#

9QM58EED61 D31 <#FC85ED6#α#<#FC85ED61 .61 236E61 DE91

F6DEE361 8F1 3E61 A694E61 61 3F7861 61 58FDC861 2341 6E9F84E61 3E61 C8D(9D61 8E1 DDE4894DE1 *8F1 A61 D5A56E91 D31 61 8E94DF,1 DEE31D31A61ED5161A694EDC8D(9D61*R,1=E1F68EC61A61FD9(61 E61 D8E91 81 61 236E61 F961 E61 DE91 81 F6DEE31 8F1 A61 58FDC861 691 DE1 EDE1 C8D(91 .61 5DA61 691 DCF6E91 861 A81 7DF961 4F3A6E61 61 D3C61 E91 2341 EBDE91 81 61 58EED6#α#9QM1 # 9QM58EED61 *@MA1 @RL,1 '46E1 23B4A1 EB64961 81 61 DFFA894DE1 6E9F61 FD9(61 691 4961 B4E7694DE1 A3463F1 9361 3F6E91 AB45A4894DE1 31 FD9(61E918E1A614E7694DE13F4E84F613A5DE84F61D31A61%89F45461 461 A31 A61 FD9(61 E91 691 F69FD31 66E946AA656E91 8E1 A61 D3C61 C3584E616919F1F8F656E918E1AB6E4FDEE656E91*M@1RM1@VL19L,11 <61 D3C61 61 FD9(61 E@1 DE91 91 6341 A61 8EE61 UL1 8D461 831 (EFD561A4E423618D48E913E18%1F4549471317D46169161D5A4894DE1 59898942361 *6EDC98A5461 5E4E496,1 A8F656E91 F491 6E1 461 *@RV1 RO,1 <61 D3C61 4DA61 61 61 4E7694DE1 DE91 A61 A31 D36E91 C(6F5323636169191E6145A42318E1A81(E9C6161A8183A61DE91 91 FDD1 D5561 78963F1 61 4F3A6E61 <61 F6546F1 E61 8B#*1 *879AE9EA BEE9AB6&3 #6563 *,1 691 F6E91 C6F1 RU:1 61 D3C61 4DA61 B8%1 C8942361 A1 B8491 B3E1 E61 CFD5DD542361 *+,C141,1

AD8A41 8E1 ABDFDE1 83A84F61 *4E,1 691 4742361 31 FD9(61 E@1 *RO1 9U1AR1ML,1381F6E61691DFFA61861A61CED9(61C(6F5323631 A81F498E611A81C8D(9D61691831F35169113E61A31F8E614F3A6E61 C6F1 A81 D3F41 *RO,1 1 .61 CED9(61 C(6F5323631 639#9F61 541 6E1 46E618F1A619F4E19691*743F619,1

(17)

1

1 9G1 39F4E1 9691G1 <B94F656E91 B3E61 DADE461 61 123 4567895AB61 FDD2361A817DF58E94DE1B3E174A161A3161A55161ADE363F16E17863F131 CED9(61C(6F53236314B8F1;3163B21*9UV,11

1

<61 6DE1 E61 8D41 831 4E7694DE1 4E8461 D84*1 *D6#7B9D3 9-3 !63 879A&3 4!659 46,1 81 91 F491 6E1 @RUR1 8F1 58471 691 B21 *@U@,1 A1 B8491 B3E1 E61 A85442361 DEE31 D5561 3E1 8948963F1 9F8EF494DEE6A1 61 A81 (E9C61 31 DA(8C8F461 69F883A84F61 477F6E91 61 A81 83A61 691 8F9448E91 831 8F89F61 C(6F5323631 61 4DA891 <61 CED9(61

C(6F5323631 F3A961 61 A81 3FFD394DE1 31 DA(8C8F461

69F883A84F612341691D618F1A61CFD5DD561691F3A61D494656E91 8F1A61E61D84*149313F13E1A85461;3163B211 *9UU,15DE9F6E918E1 3E61 DAA694DE1 61 D3C61 61 123 4567895AB63 4361 B4E7694DE1 23B4A1 (1 83F8491 3E61 DFFA894DE1 6E9F61 CED9(61 C(6F5323631 691 F6E61 31 E61 D84*1 691 2361 A81 D6496E61 61 E61 8B#*1 *879AE9EA 3 BEE9AB6&3 #6563 *,1 691 D84*3 D96E948A46F8491 AB6F64DE1 31 CED9(61 C(6F5323631 $E61 9361 F6E961 *@OL,1 4E42361 2361 A61 CED9(61 C(6F53236316917DF9656E91DFFA1861A81F6E6131E61D84*18E1 A61 4E7694DE1 3F4E84F61 1 123 4567895AB61 C6F1 A61 8946E91 EDE1

(18)

4553EDF451 +A3463F1 9361 DE91 98%A491 61 DFFA894DE1 6E9F61 FD9(61 691 F6E61 61 E61 8B#*1 691 D84*3.1 A61 F3A9891 3F6E91 2361 A61 FD9(61 E@1 D31 E91 DE91 61 96F54E8E91 61 4F3A6E61 A31 45DF98E91 2361 A61 E61 8B#*1 691 D84*1 *9UU,1 461 A31 AB8E8A(61 61 'F461 63 B21 *ML,1 4E42361 2361 A61 D3C61 61 FD9(61 E@1 F6DE8%A61 B8%1 C8942361 EB88F946EE6E91 81 831 5561 D5A661 ADE831 *..,123616AA614DA61B4E7694DE1F64F89D4F6169161%89F45461A16E1 691 61 5561 D3F1 A61 D3C61 61 FD9(61 83A84F61 E91 2341 DE91 49F4%361 8F541 A3463F1 ..1 .61 D%6F894DE1 95D4E6E91 61 9F8E76F91CDF4FDE983183164E161ABDFDE14E1F6DE8%A6161A81(E9C61 31 DA(8C8F461 83A84F61 =E1 DE236E61 A81 96F54E894DE1 31 ..1 %861 3F1 A81 96F54E894DE1 61 6236E61 9(61 *3>,1*3E1 D5A661 ADE8A1 6391F6FD36F1A3463F13>,169154631DFFA61A814F3A6E6161D3C61 2361A61FD9(61

1

93DD1

4477F6E9618C4E61DE9119154616E146E61C6F11234567895AB61<61 96F561 B8C4E61 691 394A41 D3F1 A81 ED54E894DE1 61 5DA3A61 8F461 45A42361 8E1 AB8C4DE1 61 %89F461 831 6AA3A61 61 ABC&961 .61 5DA3A61 D36E91 3E1 F&A61 66E946A1 8E1 A81 F654F61 9861 31 FD631 4E7694631 <61 FDF491 B8C4DE1 61 $56D9FB6DAB6B63 DE91 EF8A656E9154618F1477F6E919(61614A41D31745%F4861.61DE9161 9F393F61 FD942361 EDE1 7A86AA84F61 691 74A856E96361 7DF58E91 61 86E461 1 A81 3F7861 61 %89F461 2341 DE91 A81 88491 B8A394E6F1 A61 F(9CFD(961'46E12361A619196F5614A41691745%F4861D46E91C8%4936AA656E91 DE4F1 D5561 (EDE(561 4A1 6F846E91 9F61 477F6E41G1 745%F4861 D3F1 AB8C4DE1 831 6AA3A61 691 4A41 D3F1 A61 86E461 7DF51 ADF1 61 A81 DE384DE1

A1DE917DF5161477F6E961D3#3E491<616319(6161745%F4861A61 A31F6EDE9F1C6F11234567895AB63DE91A619(61@1691A619(61M3

•1<61 745%F4861 61 9(61 @1 DE91 A61 54631 DEE31 691 DE91 F6E91 C6F1 A81 58DF491 61 6E9FD%89F461 *743F61 M,1 A1 DE91 A81 A31 F8E61 88491

(19)

B8C4DE1 A1 DE91 45A4231 8E1 A81 DADE4894DE1 61 9F8931 F64F89D4F61 691 3F4E84F61 <63F1 F&A61 81 A84F656E91 91 5DE9F1 D3F1 $E!6DA!AB3 9A1 831 D3F1 61 4E7694DE1 3F4E84F61 <63F1 F&A61 D3F1 123 4567895AB61 81 91 8A656E91 F491 8E1 3E1 5DA61 53F4E1 *9R,1 .61 745%F4861 DE91 8F89F41 8F1 A63F1 8949361 1 A46F1 A61 F431 58EED61 <81D3#3E491F6DE8%A6161A8147449161A484DE18313F616911$1 *9M,1 <B4E894894DE1 31 E61 DF6DE8E91 8%DA491 A81 88491 B8C4DE1 61A81%89F461.C6F1$239A1D5561C6F11234567895AB61AB6F64DE161 745%F4861 61 9(61 @1 691 D35461 1 3E1 CED5E61 61 8F4894DE1 61 C861 *9F8EF494DE1 D31 EDE1 31 E61 D8E91 A81 FD94E61 B8C4DE1 6ADE1 A81 C86,1 =E1 677691 61 8C4E61 636E91 8E1 6F984E61 493894DE1 8D4F1 3E1677691A9F61D3F1A81%89F4613423B6AA6178DF46E91A81C8D(9D61 4E41 A63F1 (E9C61 691 78DF461 8E1 AB8F%F61 3F4E84F61 691 FF4561 8E1 A619431F4C616E16AA3A61C8D(984F61

1

1 1

1 :G1 39F393F61 74%F4AA84F61 D3F8E91 A81 3F7861 %89F46EE64B8F1 +DC3E163B21*9LV,11

1

•1<61FDF49161745%F4861619(61M1DE915D4E1%46E1DEE361A1DE91 45A4231 8E1 AB8C4DE1 61 123 4567895AB61 1 477F6E91 9(61 6AA3A84F61 8F1 665A61 831 49CA4351 3F4E84F61 691 F64F89D4F61 <63F1

(20)

894491E649613E1DA(694614>&1*9MU,12341784A4961A81A484DE11A81 565%F8E61 %88A61 61 9431 C3584E1 5841 A63F1 F6963F1 6AA3A84F61 EB81 81 91 46E94741 <63F1 F&A61 D5561 78963F1 61 4F3A6E61 F6961 C(D9C9423618E1 A3463F15DA61B4E7694DE1 *3F4E84F613A5DE84F6,1 58E5D4E131784912361619F393F6165%A6E91784A496F1AB8C4DE1161 3DF91 4E6F961 691 8D4F1 3E1 F&A61 8E1 A81 7DF5894DE1 61 %4D74A51 6AA61 D3FF846E91 8F9446F1 1 A81 C(4D89CDAD461 61 4E7694DE1 3F4E84F61 3F1 DE61

1

:19B-3BD1

$E1 839F61 78963F1 61 4F3A6E61 45DF98E91 691 A81 D4%4A491 23BDE91 A61 %89F46161896F1A6176F16E4FDEE8E91FK611619F393F618F943A4F61 A614FDCDF61=E1677691A8189894DE13176F169166E946AA611A81FD48E61 6911A81FA4894DE1A53A9161%89F461691D3613E1F&A618E1AB4E98AA894DE1691 A81FDF64DE161AB4E7694DE148E1ABDF8E456161ABC&961A6176F1EB691811 AB9891A4%F6158418D41161A(DFD94E6196AA612361A819F8E76FF4E61691A81 A89D76FF4E61 48E1 61 DE494DE1 A61 %89F461 DE91 %6D4E1 B3E1 (9561 8(8E91 3E61 7DF961 8774E491 D3F1 A61 76F1 88%A61 B6E9F6F1 6E1 D59494DE1 861 61 A(DFD94E61 <61 F4E48A1 (9561 691 6A341 61 4FDCDF61 2341 DE9161CA8963F161%81D415DA3A84F6161A48E9183176F1D31A817DF561 76M[16E16CDF161A816AA3A616912341DE916E349618918F161F6963F1 61A81565%F8E616AA3A84F61BD\1A6176F16F81A4%F18E1A816AA3A618F146F1 58E4561.614FDCDF61896E91A6176F18613E618774E4911323B1@L1 7D413F463F6116AA613176F1D3F1A819F8E76FF4E61D311A81A89D76FF4E611

A1 6E1 64961 M1 9(61G1 A61 6E9FD%894E61 A61 8FD%894E61 691 A61 (6F4E8%894E61 <61 6E9FD%894E61 DE91 61 4FDCDF61 61 9(61 896CDA8961 A61 8FD%894E61 61 4FDCDF61 61 9(61 C(FD858961 691 A61(6F4E8%894E61614FDCDF61619(61C6EDA8961*@AL,11

+D3F1 61 76EF61 DE9F61 AB4E7694DE1 A61 585547F61 DE91 6AD1 3E1 6F984E1 ED5%F61 61 58E4561 6AD498E91 A61 %6D4E1 6E1 76F1 61 %89F461 $E61619F89461D3F1A45496F1A81FD48E61%89F46EE61691B8356E96F1

(21)

AB6F64DE1 61 F6963F1 61 A81 A89D76FF4E61 691 61 A81 76FF494E61 2341 6E9F84E6E91 3E61 454E394DE1 61 A81 DE6E9F894DE1 F42361 31 76F1 *@M,1 $E61 9F89461 A31 4742361 45A42361 A81 A4D8A4E61 91 *<E91 D31 567D94!A3 #6BA5BE6BEE9AB6&3 A49BA51 D31 4FD8A4E61 D31 396FD8A4E6,1 .69961

FD94E61 %89F4D98942361 691 F6E961 8E1 A61 F8E3A61 61

DA(E3A84F61 E639FDC4A61 691 6391 9F61 F961 6E1 FDE61 1 3E61 894894DE161F6963F1>DAA#A4I611*><C,1<E918161A46F1161D5A661 4FDCDF6#76F1DE91AB6E9FD%894E61FD349618F1A616E9FD%89F461<E91 66F61 DE1 894491 %89F4D98942361 6E1 2369F8E91 A61 76F1 D5A61 1 AB6E9FD%894E61 F48E91 84E41 A81 %89F461 61 76F1 +D3F1 D36F1 61 4D49471 A61 6E9FD%89F461 DE91 88%A61 61 78%F4236F1 61 7DF561 8A96FE89461 B6E9FD%894E61 *8A5DCA4E61 6E9FD%894E61 A(D(A61 F4961 C6F1 /B8956B3 656DAB,1 <81 (E9C61 61 61 FD94E61 691 D31 A61 DE9F&A61 B3E1 A396F1 61 E61 AD9 1 F69FD31 8A656E91 C6F1 $29A1 691 13 24567895AB61 *@,1 <61 A396F1AD9 1 D61 D3F1 A1 FD94E61 45A42361 8E1 A619F8EDF91691A815D474894DE161AB6E9FD%894E61G1FD'1FD=1FD41FD.1691 FD51 74C%8C1 63 B21 DE91 5DE9F1 2361 A61 A396F1 61 E61 AD9*1 8E1 61 D3C6189CDE6161$29A161/B8956B1D3161124567895AB6178DF461 A63F14F3A6E618F1ABC8656E911AB894DE161A81FD94E61<E91*RR,1

'8C58E1 63 B21 *@@,1 DE91 9341 @9R1 D3C61 61 123 4567895AB61 F6DE8%A61B4E7694DE16146F14961<614FDCDF6161AB6E9FD%894E61 98491 F69FD31 8E1 @LL:1 61 D3C61 =E1 F68EC61 A81 (6F4E48%894E61 EB98491 F6E961 2361 C6F1 @V:1 61 D3C61 *99Q@9R,1 691 66E946AA656E91 8E1 6AA61 F6DE8%A61 B4E7694DE1 F64F89D4F61 *@@QMM,1T1 AB8FD%894E61 98491 F8F656E91 F69FD361 *MQ@9R,1 A1 DE91 5DE9F1 2361 *4,1 A61 D3C61 D8E91 A81 (6F4E48%894E61 DE91 8D461 1 3E1 F42361 A61 B4E7694DE1 3A5DE84F61*44,1A81(6F4E48%894E616F5691831D3C61611234567895AB61 BC86F1 1 AB894DE1 61 A81 <E91 8E1 A61 D35DE1 838E91 8ADF1 3E61 E635DE461 *444,1 A81 (6F4E48%894E61 81 3E61 7DE94DE1 48A461 8F1 6AA61 9453A61A81FD48E61611234567895AB618E1A61D35DE15841818E1A61 6F351 *4,1 A61 D3C61 6F458E91 AB6E9FD%894E61 DE91 F6DE8%A61

(22)

B4E7694DE1 3A5DE84F61 DDF93E4961 D38E91 9F61 F61 6E1 AB8%6E61 61<E91<61D3C61D8E91614FDCDF61F498E911A81<E91DE91 D36E918D4618314E7694DE1D553E83984F616E18F943A46F1A618%1 C8942361 F8DF91 6E1 461 A1 DE91 31 1 61 D3C61 61 123 4567895AB616F458E916153A94A614FDCDF61F498E911<E91DE91A81 (6F4E48%894E61691AB6E9FD%894E61A(D(A61*@,1

1

1D1 CBECD1 *D31 6E9FDCDA4E6,1 DE91 A61 4FDCDF61 A61 A31

D36E91F6EDE9F1T14A1DE91F6E91C6F1A81A38F9161D3C6161123 4567895AB61 <61 AD31 61 61 4FDCDF61 D5F6E1 61 ED5%F631 E61 DE916F 11

1

1,BEC1 691 FD34961 8F1 3E61 784%A61 FDDF94DE1 61 D3C61 691 81

3E61A31784%A618774E491D3F1A6176F12361AB6E9FD%894E61<61E61A81D8E91 691 DF91 8F1 3E1 A85461 DE389471 A1 81 91 5DE9F1 2361 A81 FD394DE1 B8FD%894E61 98491 8D461 1 3E61 8356E9894DE1 4E47489461 61 A81 4F3A6E61 61 123 4567895AB61 8E1 3E1 5DA61 53F4E1 61 F49DE4961 *9U1 @UL,1

1

11 )DEC1 81 91 F4961 6E1 @RRM1 8F1 0BB#3 63 B1 *@@V,1 <B8234494DE1 61 4FDCDF61 96A1 2361 A81 (6F4E48%894E61 8F1 6F984E61 %89F461 7DF58E91 61 6AD91 BC(6F89CDE4491 "+1 10A#! %B!9#65AA 3 2EB5&E,1 65%A6E91 8D4F1 91 3E61 9861 F45DF48A61 8E1 ABDA394DE16189CDE61

<61 AD31 61 A81 )DEC1 F491 C6F1 C6DEA5AB3 46EAE1 691C23 656D999AAB18F1=1.8FE46A16E19LL@1*A,169149313F13E16AD91*M1,1 DF963F161A396F161E6145A42318E1A81(E9C61A619F8EDF91691 A81 F3A894DE1 61 A81 (6F4E48%894E61 .61 AD31 691 7DF51 61 @@1 E61 DF8E416E11DFDE1*743F61,1*98%A6831@,1<817DE94DE168961619D31 61E61EB691819D98A656E91A346158414A1636E919F614416E1 M1FD3617DE94DE6A1G1

(23)

3(E9C61 61 A81 (6F4E48%894E61G1 AD41 AD41 *AD953 D6#7B9D 3 4D96A5,1 *@O,1 2341 D6E91 F6694656E91 A61 FD94E61 "1J+@1 691 +91 *!A#! 8967BD)6A#!3 4D96A5,1 F1 F$1 691 F/1 2341 D6E91 61 9C4D696F861T3

• >F8EDF91 61 A81 (6F4E48%894E61 691 31 76F1 8E1 A61 %89F461

*F66963F1 69F8565%F8E84F61 691 9F8EDF963F,1G1 4E53- 7*1

*46EAA53 D6649DQ1 -6DDA3 6DEA5ABFBA53 D6649D,1 2341 D6E91 61 F66963F1 696FE61T1 F%1 691 F41 *RV,1 2341 D6E91 61 F6963F1 9F8E565%F8EE84F6T11

C3A894DE1G1 F*1 691 3E1 8948963F1 9F8EF494DE6A1 61 E61 611 F66963F1 *4E53- 7*1 F%,1 691 61 A81 (E9C61 61 A81 (6F4E48%894E61 *AD4,16914A1691FF663F161DE1FDF61FD5D963F1

1 1 1

1 ;1"1 C6F6E9894DE1 61 M1 6AD91 61 89CDE4491 C839656E91 89CDE61 61 C6DEA5AB3 E41 <61 7AC61 ED4F61 F6F6E96E91 A61 AD31 61 A81 (6F4E48%894E61 A61 7AC61 F461 A61 8F9461 8F48%A61 A61 7AC61 %A8EC61 A61 DFDE1 <61 DF71 *94653 D6B&A5#3 -DB86,1 E35FD961 DE91 FD%8%A656E91 61 E61 FD6E8E91 61 %89F4DC861 4B8F1 .8FE46A1 9LL@1*A,1

(24)

8F81"1<D3161A81(6F4E48%894E6161C2346EAE1C234E67&97F6D79EAE1 691C23656D9AAB1G1E61FD34917DE94DE14B8F1.8FE46A19LL@1*A,1 1 1 ;6FBC11-C3BEC1 1

<B6AD91 81 B8%DF1 91 F491 C6F1 C23 46EAE1 C23 4E67&97F6D79EAE1 691 C23 656D9AAB1 %4D9(61 @'G1 *4,1 4A1 B8491 B3E1 F8E1 7F856E91 CFD5DD542361 B 451 *MA1 #1 A1 I%,1T1 *44,1 4A1 DF961 A61 E61 61 4F3A6E61 6E1 8F943A46F1 A61 AD31 61 A81 (6F4E48%894E61 4E46E8%A61 1 AB6F64DE1 31 CED9(61 C(6F#4F3A6E91 61 C6DEA5AB3 E421T1 *444,1 4A1 B4EF61831E4683161A8196F54E84DE1MB131E6161AB C51619F8E76F9161 AB88F84E63*BE53*56,1T1*4,1A619831612[.:1691477F6E91616A34131 F696131CFD5DD561691*,14A16917A8E23161236E61F961*M1 ,11*743F61,1.6916AD91DE946E9161ED5%F631E61DE91A61AD3161 A81 (6F4E48%894E6G1 81 7DE94DE1 66E946AA61 691 61 896F1 61 5DA3A61 6176F166E946AA611A81FD48E616911A81454E894DE161A81%89F461 48E1A81F4DE1MB1A81F6E61B3E614E9F861*A5,1691614961B3*4961 B4E9F894DE,1454A84F61163131C861+18613E1DE96E3121[1.:1 A31A612361A61F696131CFD5DD5613F612361AB"+1819182341 8F1 4E9F894DE1 CFD5DD542361 31 C861 1 FD45491 31 E61 61 AB4E9F861 61 9FD361 A61 AD31 61 ABBE53 *E61 D8E91 D3F1 AB C51 61 9F8E76F91 61 AB88F84E6,1 <61 631 69F5491 61 AB"+1 DE91 %DF61 8F13E61236E61F96161@V184F6161%86146E942361 ADF12361 A81F4DE1MB165%A61F6A894656E91DE6F618E1AB"+161C6DEA5AB311 6AA616918F48%A618E1A818F9461AB1*743F61,1461"+1DE9191F69FD31 C6F1 B839F61 6E9FD%89F461 96AA61 2361 $23 9A1 723 &A6DE7E1 16FEA6B3

(25)

23/B8956B3656DAB3G16AA61F3A96F846E91B3E19F8E76F91CDF4FDE98A11 8F94F1 31 CFD5DD561 61 C6DEA5AB1 *@L1 A1 @RR,1 48E1 6F984E61 6E9FD%89F461AB"+1691F6A894656E91DE6F1*$29A3723&A6DE7E3123 4567895AB6,1 5841 61 A94DE1 DE91 91 D%6F61 C6F1 B839F61 *123 9 9B,1 *@L,1 1 EDF3F81 63 BDE91 1 9341 ABDF8E4894DE1 61 AB"+1 61 M1 D3C61 61 123 4567895AB61 4DA61 61 FA656E91 A4E42361 46F1 *@O,1 +8F541 61 D3C61 63A61 O1 8846E91 3E1 "+1 *+.C1 D49461 D3F1 A61 F456F1 6F56998E91 61 9696F1 A61 E61 61 (E9C61 61 A81 (6F4E48%894E61 AD41 691 AD41 691 A61 F6963F1 61 A81 (6F4E48%894E61 - 7*,1Y389F616161O1D3C618846E913E1E61- 7*161VAL184F6161 %861 *%,1 8ADF1 A61 7F856E91 DFF6DE8E91 C6F1 C23 46EAE1 691 61 VUL1 %1 <B9361 61 AB"+1 61 2389F61 D3C61 81 5DE9F1 3E61 46F491 61 ABDF8E4894DE1 61 E61 861 3E61 A94DE1 B3E61 D31 A3463F1 F4DE1 *743F61 A,1 =E1 F68EC61 1 AB"+1 61 9FD361 9D3D3F1 1 FD45491 31 E61 61AB*56361AB88F84E63*@O,1

1

1 1<1G1.D58F84DE161ABDF8E4894DE1E94236161AB"+161C6DEA5AB1 18E11D3C61611234567895AB623<61DA(DE61ED4F1F6F6E96E91 A61 E61 F6E91 691 A61 DA(DE61 %A8E1 A61 E61 8%6E91 <61 9F8491 ED4F1F6F6E96E91A61FDE6185A474614B8F1EDF3F8163B1*@O,11 1

1

(26)

<?16CC1 1 5B5C1 3F1C1@1 A65321 F1C1 ,CB1C11EB5DBB1

1

<61 9F8E76F91 CDF4FDE98A1 61 E61 4E9F8#661 691 4E96F#661 D361 3E1 F&A61 66E946A1 8E1 ABDA394DE1 691 A81 88491 B889894DE1 61 %89F461 *U91 @UR1 @M@,1 >FD41 58E4561 F4E4831 A81 9F8E7DF5894DE1 A81 9F8E394DE1 691 A81 DE384DE1 *VU,1 6F56996E91 1 61 D3A894DE1 %89F46EE61 B823F4F1 61 E61 8F1 9F8E76F91 CDF4FDE98A1 61 FDEF61 84E41 F84656E91 831 741 691 9F61 6E4FDEE656E9831 *@@R,1 =E1 677691 6F984E61 %89F461 89CDE61 D6E91 61 E61 61 3F461 *D31 61 4F3A6E61 6E1 81 B4E7694DE1 61 ABC&96,1 2361 ABDE1 E61 F69FD361 81 8E1 61 ADE61 D31 61 661 9FD49656E91 A461 5841 EDE1 89CDE61 .61 A396F1DE91FD%8%A656E9149313F161C861D3161A854615841 DE91 D36E91 F69FD31 8D41 1 61 6AD91 61 89CDE4491 3F1 A61 CFD5DD561*@@1@@U,1

461 A56E91 2341 B646E91 691 B4E9F6E91 D5561 61 FDC861 691 DE91 9F8E7F1 8F1 DE384DE1 D5561 61 A85461 DE91 91 9FD31 8E1 477F6E961 %89F461 .61 A56E91 65%A6E91 8D4F1 61 8F89F4942361 9F1 46F61 96AA61 2361 *4,1 AB394A4894DE1 61 4A41 D3F1 A61 DE9891 61 6AA3A61 1 6AA3A61AW8F894DE1616AA3A61A619F8E76F916145A61%F4E1D31D3%A61%F4E1 B 451*44,13E61474491784%A61D31A661W4E9F894DE1691*444,161F4E61 D31 61 9(FD4E61 F6D5%4E861 461 F6D5%4E861 636E91 898A(6F1 AB4E9F894DE1 691 AB644DE1 61 7F856E91 B 451 4F3A84F61 *4E9F861 F6DA86,1 D31 AB4E6F4DE1 61 7F856E91 B 451 *4E6F986,1 <B4E9F894DE1 61 E61 61 78491 831 E46831 61 AB88F84E61 61 AB C591 *BE51 C59,1 4931 1 AB69F5491 MB1 .6A81 81 DE3491 1 3E61 ED56EA893F61 9F1 C9FDE61 4EA38E91 9F8EDDE1 DE389471 A85461 4E9F89471 6AD91 ED542361 691 1 61 ED5%F631 A56E91 EDE1 A81 >D31 61 A56E91 DE91 641 831E4683161496161F6D5%4E84DE19F8E7F1D317DF5614F3A84F618F1 DE384DE1 691 DE91 4E9F1 831 E46831 B3E1 4961 4742361 4931 8E1 A61 ED561 61 A81 6AA3A61 C&961 *743F61 O,1 ADF1 2361 A81FA4894DE1 61 A81 7DF561 4F3A84F61 3F46E91 8E1 D3961 6E8E91 A81 DE384DE1 69961 FA4894DE1 EW6918145A423618E1A61584E946E161AWA56E91.61A56E91DA36E91

(27)

8F1 8234494DE1 D31 C8E61 61 7F856E91 B 451 861 46F1 A56E91 E942361 9F8E7F8%A61 .61 A56E91 9D391 D5561 A61 A85461 DE389471691A61FDC8616F846E91F6DE8%A61619F8E76F91CDF4FDE98A1 61E61*9VR,1B1'3FF31691B1DE91FDD16E19LL9161A61A86F1D5561 61 A56E91 W4E9F894DE1 691 61 DE384DE1 .=1 *256#DBA63 B5&3 79587#BA63$6865E,1*M9,1

1 1

1 1

1 !1G1 4477F6E961 9861 B4E9F894DE1 61 AB 451 8E1 A81 6AA3A61 C&961 $E1 A56E91 W4E9F894DE1 691 61 DE384DE1 *.=,1 691 4E9F1 831 E46831 B3E1 63A1 4961 8E1 A61 CFD5DD561 61 AWC&961 691 691 7A8E231 8F1 61 236E61 4742361 3F1 A81 FD4961 *B591 691 A81 83C61 *B:,1 F1 644DE1 61 7DF561 3E61 5DA3A61 4F3A84F61 76F561 F3A98E91 B3E61 A484DE1 W3E61 F6D5%4E84DE1 6E9F61 B:1 691 B51 D3F1 DEE6F1 ABB%1 *8E1 AB.=,1 691 ABB1*8E1A61CFD5DD56161AWC&96,1$E616AA3A61E361B.=#A4%F616391 6F4F1 61 6AA3A61 F69F461 31 D3F1 61 A81 DE384DE1 A61 DEE63F1 691 A61 F6663F1 DE91 541 6E1 DE9891 9FD491 691 3E1 451 45A61 %F4E1 691 9F8E7F1 6F1 A81 6AA3A61 C&961 FK61 1 AW894DE1 61 A81 FA4894DE1 6E1 6FA61 FD3A8E91 F1 A61 9F8E76F91 AB 451 DA(5F861 61 A81 6AA3A61F69F461 (E9C9461 A61 %F4E1 D5A56E984F61 61 2341 DE3491 1 A81 7DF5894DE1 B3E1 451 4F3A84F61 D3%A61 %F4E1 <B4E9F894DE1 61 AB.=1 8E1 A81 6AA3A61 C&961 61 78491 8F1 3E61 ED36AA611F6D5%4E84DE16E9F61B%1691B234B8F1JDFE48I163B23*9VR,11 1

<61F6546F1.=1D36F918191A619F8EDDE18F89F41>E;<14DA1C6F1 $56D997E3-B6BAE1*@LA,169161A56E91DE913F9D391919341C6F1

(28)

/D64997E3 691 B6D9A&6E3 1 <61 .=1 DE91 8D41 831 6AD91 61 89CDE4491G1 4A1 DE946EE6E91 61 A396F1 61 E61 8D41 1 A81 4F3A6E61691DE91F6A418318F89F6189CDE61B3E61D3C61%89F46EE611 =E1 9LL1 3C3%6F91 63 B21 DE91 8F89F41 AB6AD91 61 89CDE4491 B3E61 D3C61 B=23 9A1 $23 9A3 =.PCM@1 ED551 "+=.PCM@1 *9MA,1 <B"+=.PCM@1691 3E1 7F856E91 B 451 61 MA1 I%1 4931 1 AB69F5491 MB1 689656E91 1 D\1 691 4EF1AB3161C2346EAE169161C234E67&97F6D79EAE1.617F856E91B 451 D5F6E1M1F4DE1494E961.D55619D31A61"+3"+=.PCM@1B4EF61831 E4683131AD3161ABBE51 C591D61A61E61B3E614E9F861*A5,113E61 69F5491 691 D61 D3F1 61 78963F1 61 4F3A6E61 691 A61 (9561 61 4FDCDF61 61 A81 (6F4E48%894E61 <B4E394DE1 61 AB4E9F861 6E9F84E61 3E61 644DE1 691 3E61 4F3A8F4894DE1 61 AB1 "+=.PCM@1 D5A691 .66E8E91 AB1 "+=.PCM@1 691 1 631 7D41 A31 F8E1 2361 A61 839F61 "+1 F491 8F1 4A1 D61 3E1 7F856E91 B 451 8494DEE6A1 EDE1 D%6F1 1 61 D3F1 8E1 A61 839F61"+169149311FD496161AB69F549161AB"+11.617F856E91D61A61 (9561 61 (E9C61 691 B865%A861 61 4A41 E684F61 831 9F8E76F91 B 451<B"+=.PCM@1D611A817D41619F393F61D553E61691494E961 831 "+1 61 839F61 D3C61 B$29A1 61 C6DEA5AB3 1 691 B839F61 $56D9FB6DAB6B61*743F61V,231

(29)

1C1"1.D58F84DE161A819F393F6161477F6E91"+1G1$239A1=.PCM@1 C2346EAE1691$239A1.7>LVM14B8F13C3%6F9163B21*9MA,111

<61 7AC61 F461 4E4236E91 A61 4961 W4E9F894DE1 61 AW"+1 *88F84E61 61 E61 61 AB C591 D31 8E>1 D31 8EB,1 A61 4961 B=1 4E4231 8F1 61 861 C8C3F61 F6F6E98E91 A61 236E61 F961 61 @V1 84F61 61 %861 *4C,1 7A8E238E91 AW"+1 61 C23 46EAE1 691 61 $23 9A1 =.PCM@1 461 A4E61 6E1 D4E94AA1 ED4F1 4E4236E91 A61 CFD5DD561 D44E1 <61 7AC61 ED4F61 4E4236E91A61E61A51691- 7*358F238E91A81A45496131DF6161AW"+1C'#"+1 =.PCM@1 74E491 A81 AD8A4894DE1 61 M1 UL1 %1 3A56E984F61 %DF8E91 A81 8F9461FD496161AW"+161A81D3C6161$239A3=.PCM@1

1

<B4E9F894DE1 CFD5DD542361 AB644DE1 691 A61 F6D5%4E84DE1 E942361 61AB1"+=.PCM@1DE91FDC61314961474236161F6D5%4E84DE131C861 A85%81 =E1 677691 D5561 A61 C861 A85%81 AB"+1 861 8F1 3E61 7DF561 4E96F5484F614F3A84F6169F8#CFD5DD542361<61F6D5%4E84DE1617DE91 831 E46831 61 4961 46E942361 3F1 A61 CFD5DD561 691 AB"+1 <B"+=.PCM@1 B4E9F61 831 E46831 B3E1 4961 61 F6D5%4E84DE1 CFD5DD542361 ABB1 <B4E9F894DE1 691 AB644DE1 61 7DE91 FK61 1 3E61 4E9F861 *A5,1 F1 644DE1 691 4F3A8F4894DE1 3E1 4961 4742361 B%1 691 F1 <61 DE94DE1 CFD5DD542361FD496169183C6161 AB"+=.PCM@1*B53B:,1DE917DF561 8F1 A81 F6D5%4E84DE1 61 ABB3 CFD5DD542361 691 ABB%1 61 AB"+=.PCM@1 F19F8E76F918E1A816AA3A61F69F461AB"+=.PCM@16914E9F1831E46831 61AB69F5491AB1E6161ABBE51 C591*743F61U,1

(30)

1D1"1C64F3A8F4894DE161AB1"+=.PCM@14B8F13C3%6F9163B21*9MA,11 <B"+=.PCM@1 B4E9F61 47423656E91 831 E46831 31 4961 B1 CFD5DD542361 <W4E9F894DE1 691 AW644DE1 61 AWA56E91 DE91 5461 8F1 3E614E9F861*A5,1<6169F549183C61691FD49616111AB1"+=.PCM@1B:1 691 B51 1 *4961 B8998C656E91 61 AB4E9F86,1 DE91 7DF561 8F1 A81 F6D5%4E84DE1 6E9F61 ABB1 691 ABB%1 61 AB"+=.PCM@1 F1 AW644DE1 CFD5DD542361 691 A81 4F3A8F4894DE1 3E1 4961 4742361 61 F6D5%4E84DE1 *B%,1691F1<B"+=.PCM@1691F6F6E918F161A4E61ED4F61A61E6161 AW4E9F861 8F1 1 3E61 7AC61 ED4F61 691 AW 451 CFD5DD542361 D44E1 6E1 F41 <61 4961 B%1 *+#P#+,1 691 F6F6E91 8F1 61 861 ED4F61 C8C3F61 6E8F8E91 A61 P1 *861 ED4F61 A64E6,1 DE94938E91 A61 DF61 31 4961 B8998C656E91A614961B16915DE9F16E1F4

<B1"+=.PCM@1FDE8E91831F49F61619F393F6161AB.=174E418F1'3FF31 63B214A18191ED551.=$1A165%A612361AB.=$36F84919F8E7F18F1 3E1 (9561 61 F94DE1 61 9(61 B1 8E8AD361 1 3E1 9F8E76F91 61 A85461 8F1DE384DE11

<B.=1 61 123 4567895AB61 .=41 81 F6556E91 91 F491 8F1 <4E1 63 B1 *@AR,21 =E1 D58F8E91 A81 236E61 D5A961 61 631 D3C61 61 1 123 4567895AB61 5>$"#E9L1 F6DE8%A61 B8%1 C8942361 *9U@,1 691 12"VUAVU1F6DE8%A61B4E7694DE13A5DE84F61*@R@,1A81F6E61B3E1.=1 DE96E8E913E1"+13E423656E918E1A81D3C615>$"#E9L1819154616E1 6E61 ED551 .=41 A1 B8491 B3E1 7F856E91 B 451 61 VO1 I%1 B4E9F8E91 831 E46831 31 E61 D8E91 ABBE51 *563 691 7A8E231 8F1 3E61 236E61 F961 61 @V1 %1 *743F61 R,1 <61 9831 61 2[.:1 691 61 AU:1 D58F1 1 A9:1 8E1 A61 F6961 31 ED561 .61 2341 3F61 2361 69961 DF94DE1 CFD5DD542361 81 91 823461 8F1 9F8E76F91 CDF4FDE98A1 <B8E8A(61 61 A81 236E61 E3AD9442361 61 61 7F856E91 B 451 81 5DE9F1 23B4A1 98491 441 6E1 9FD41 F4DE1 7DE94DEE6AA61 691 23B4A1 88491 3E61 9F393F61 D58F8%A61 1 6AA61 61 AB.=$1 61 A81 D3C61 =.PCM@1 <81 F4DE1 AB1 691

(31)

454A84F61 1 AB"+1 61 C6DEA5AB3 21 F6DE8%A61 61 A81 (E9C61 61 A81 (6F4E48%894E61 691 8D461 1 A81 4F3A6E61 61 A81 %89F461 <81 F4DE1 5D(6EE6198491454A84F6113E618F946131A85461<B+E1*AM,161A81D3C61 61114567895AB61.2M1691A81F4DE1MB1D5DF98491A61E61619F8E76F91 691 5D%4A4894DE1 61 AB.=1 61 A81 D3C61 B$29A1 =.PCM@1 *743F61 @L,1 <B.=1 B4EF61831E4683161AB8E161AB C591<81D58F84DE1611E6161ABBE51 *561 61 D3C61 61 $23 9A3 691 61 631 D3C61 61 123 4567895AB61 *5>$"#E9L1 691 12"VUAVU,1 81 5DE9F1 23B4A1 (1 88491 3E61 4E6F4DE1 831 E4683161ABBE591691161A81D3C616112"VUAVU1*743F61@@,1 1 1 1 1 1 E1"1 2-DCCB1 DE31C01 1 F1 -BCB1 1 C!1 >1 <61 A4E61 6E1 D4E94AA1 4E4236E91 AB4E6F94DE1 8E1 A81 D3C61 61 123 4567895AB61 5>$"#E9L1 D58F61 1 A81 D3C61 12"VUAVU1 <B4E6F94DE1 691 49361 831 E46831 31 E61 61 ABBE51 *561 61 AB88F84E61 4E4231 8F1 61 7AC61 F461 <61 %D4961 C8C3F61 *4C,1 4E4236E91 A61 4961 B8998C656E91 B=1 D5D1 B3E61 236E61 F961 61 @V1 %1 <61 7AC61 ED4F61 4E4236E91 AB4E9F861691A61E61- 7*3*F6963F161A81(6F4E48%894E6,149318E1 A61 8F9461 96F54E8A61 AB1 691 MB1 61 AB"+1 461 7F856E91 61 MUL1 %1 691 9AMM1 %1 346E91 F6694656E91 AB"+1 61 $29A1 =.+CM@1 691 61 1233 4567895AB615>$#E9L1<4E1><163B1*@AR,1 1 1 1 1 1

(32)

18FG1C6F6E9894DE1C5894236161AB.=I@1 1881"1C6F6E94DE161AB8A4E656E9161BE51*5638E1A61D3C61 B$239A1=.+CM@11234567895AB615>$#E9L11234567895AB6112"VUAVU1 <4E1><163B1*@AR,G11 1 !CD1.D11FE1

• 4631 F4DE1 CFD5DD542361 DE91 F6556E91 91 46E947461 C6F1 A81 D3C61 61 123 4567895AB61 5>$"#9L1 *5894DE8A1 >84H8E1 $E46F49(1 "D498A,1 *9U@,1 4DA61 B3E1 8%1 C8942361 8D41 1 3E61 5E4E4961 8ADF1 23B6AA61 DE91 8%6E961 31 ED561 61 A81 D3C61 12"VUVAU1 4DA61 B3E614E7694DE13A5DE84F61*@R@,1G11

# 2E6131598%DA456161AB8AA8E9D4E61

<61 E61 4E96F6E8E91 8E1 A61 598%DA4561 61 AB8AA8E9DSE61 FD3491 96F54E8A1 BA454E894DE1 31 598%DA4561 3F42361 691 AB3E61 61 F4DE1 46E947461 C6F1 A81 D3C61 5>$"#E9L1 *AO,1 .69961 F4DE1 61 99#I%1 D5F6E1 @1 E61 DE91 A61 E61 B/1 2341 D61 3E1 8948963F1 61 AB6F64DE1 31 F3ADE1 8AA8E9D4E61 .69961 F4DE1 E61 65%A61 81 DE94936F1 3E1 6AD91 61 89CDE4491 8F1 6AA61 E61 DE946E91 81 B4E9F861 D31 61 E61

(33)

615D%4A491=AA616914E474894656E91A317F236556E91F6E961C6F1A61 D3C61 4DA61 B8%1 31 7D461 *AO,1 48E1 3E1 5DA61 6F456E98A1 B4E7694DE1 4E9F8#89F42361 53F4E1 A81 A94DE1 61 69961 FDE61 B8D58E61 B3E61 F394DE1 61 A81 4F3A6E61 +8F1 84AA63F1 4A1 81 91 5DE9F1 2361 123 4567895AB61394A461AB8AA8E9D4E61D556163A61D3F61618F%DE61B8FD961691 BE6F461 6E1 8FD%4D61 D5561 6E1 8E8FD%4D61 .6F984E1 8946E91 8(8E91 61 89CDAD461 CFDE42361 FC3589458A61 3A5DE84F61 D31 3E1 48%961 EDE#4E3A4ED#6E8E91 DE91 61 DE6E9F894DE1 F42361 A661 6E1 8AA8E9D4E61 .6F984E61 D%6F894DE1 F8DF96E91 3E61 7F236E61 8F361 61 8%1 C6F1 61 8946E91 8(8E91 3E1 48%961 EDE1 4E3A4ED6E8E91 <B8356E9894DE161A81DE6E9F894DE1B8AA8E9D4E61F42361D3FF8491DE94936F1 3E178963F178DF48E91A616AD656E91618%1*AO,11 #C4DE131(9561-71 18163B21DE915416E146E613E61F4DE1CFD5DD542361831E4683161A81 D3C61B6E4FDE19L1E%1DE96E8E913E1(95616189894DE13176F1-733E1 (9561 61 CDCDEDA(F38961 3F61 CDCD9F8E7F861 *+>3,1 691 A3463F1 E61 DE91 A81 7DE94DE1 691 6EDF61 4EDEE361 <81 F6E61 61 A81 F4DE1 -73 88F8491 8A656E91 A31 7F236E961 C6F1 A61 D3C61 4E8461 *@OV,1

%2B61

<B9361 61 C631 63 B1 *99,1 81 5DE9F1 23B3E61 539894DE1 3F1 A61 E61 7#61 D8E91 D3F1 AB$4+1 8A893FDE8961 #45F861 F6E1 A61 D3C61 61 123 4567895AB63D3F36161<+316916183A61.61D3C615398E961DE91 4E88%A61 61 FDD236F1 3E61 4E7694DE1 3F4E84F61 D31 3A5DE84F61 C6F1 A81 D3F41 <61 E61 7#61 E61 65%A61 81 8D4F1 61 A46E1 861 A81 F6E61 D31 AB8%6E6161CED9(61C(6F5323631*9UU,1

1

666 2DDCE11&-2F6B8FED62/1CBC0D1

89DFC1CFF11&-2F6B8FED61

123 4567895AB61 88F946E91 831 FD361 91 61 A81 A8474894DE1 61 6E9FD%89F4616E17DE94DE161A63F1F498E61E893F6AA61831β−A89854E61 .69961661D61E893F6AA656E913E1E61D8E91D3F13E61E44AA4E861

(34)

CFD5DD542361 *861 A3463F1 8F48E91 3"B1 <=51 PE+,1 2341 A341 DE7F61 3E61F498E611%81E46831831E44AA4E61*854ED#18F%D(#16913F4D# E44AA4E6,1 .69961 E44AA4E861 691 6E4%A61 1 AB894DE1 61 4EC4%4963F1 *8461 A83A8E42361 98FD%8985,1 4E41 A61 CED9(61 83861 61 123 4567895AB61 691 6E4%A61 831 8D4894DE1 85D44AA4E61 *D31 948F4AA4E6,1 [1 8461A83A8E423616914F84AA4E61[198FD%8985184E4123B1AB6E65%A6161 C8ADDF4E61 =AA61 691 8A656E91 6E4%A61 831 785(4E61 1 AB8F9FDE8516918318F%8E561

.DE6FE8E91 A61 839F61 8E94%4D942361 123 4567895AB61 691 6E4%A61 831 854ED4618317A3DFD234EDADE611A817D7D5(4E61691831D9F45D8FDA61 1

92DDCED1E0DD11&-2F6B8FED61

46341 9D3D3F1 691 D3F1 61 F84DE1 6EDF61 4EDEE361 123 4567895AB61 D361 3E1 F&A61 5863F1 8E1 AB88F494DE1 69QD31 A81 454E894DE1 61 58E456161F498E616E18F943A46F14##4161β#A89854E611

1234567895AB61819D3D3F1913E61A823619D3FE8E9618E1A81F498E61831 8E94%4D942361 4E41 8E1 A61 8EE61 @RVL1 61 %89F461 DE91 91 4DEE4F61 D3F1 A61 F498E61 831 854ED461 *AV,1 1 8F94F1 61 8EE61 UL1 123 4567895AB61 81 A8F656E91 DE9F4%31 1 A81 454E894DE1 CD498A4F61 61 β!A8985861 1 69F61 96E31 *'<3=,1 2341 A63F1 DE7F6E91 3E61 F498E61831C8ADDF4E6161M561EF894DE1*.M2,1*@RA19A,1+A31 F6556E91 69961 661 D361 3E61 D494DE1 45DF98E961 8E1 AB56F6E61 691 A81 454E894DE1 61 6F984E61 6EF(561 DE7F8E91 A81 F498E61 831 8F%8E561 *E+.1 P? #U,1 <DF2361 ABDE1 78491 3E1 %4A8E1 61ED36AA61β#A8985861F49616341@RUM11234567895AB616918E1 UL:1 61 81 ABC&961 C6F1 2341 DE91 91 D36F961 61 ED36AA61 6EF(561 *61 9(61 >=11 3"B1 D31 61 A81 A861 .,1 *U1 @RA,1 <DF23B6AA61 EB691 81 A61 F6546F1 C&961 DE1 F69FD361 9F1 7F236556E91 69961 661 D5561 F6DE8%A61 61 A81 47734DE1 4542361 61 ED36AA61 6EF(561 D5561 A61 598AAD#6EF(561619(61B11*@MR19VV,1

(35)

6' 2--F1 D1 FD1 1ED1D1 ,ECB1 C1 1 DDCE1 /1ββββ FEC1D1

8 %FCD11

<61 ]#A89854E61 D3F1 A63F1 A8F61 69F61 8E94%89F46E1 A63F1 894491 %89F4461 965#6E8E91 691 A63F1 784%A61 9D4491 DE94936E91 A81 7854AA61 W8E94%4D942361 A81 A31 8961 691 A81 A31 F6F4961 =AA61 D5F6EE6E91 A61 F41 61 A81 E44AA4E61 A61 C8ADDF4E61 A61 5DED%898561 691 A61 8F%8E561 691 DE91 9D3961 6E1 D553E1 A61 (A61 ]#A898561 <61 (A61 ]# A898561 61 D5DF961 D5561 3E1 3%9F891 34461 B6EF(561 45A42361 8E1 A61 9861 74E8A61 61 A81 %4D(E9C61 31 694DA(8E61 C9FDDA(5F61 66E946A1 61 A81 8FD41 %89F46EE61 <81 %4D(E9C61 31 694DA(8E6169183F61FK611616EF(56161E893F618F46149361 3F1A817861696FE6161A81565%F8E61(9DA8542361.616EF(561A6144# 9F8E69486169144#8F%D(694861D6E913E14961894711F4E61 691 DE91 F6FD361 D31 A61 96F561 61 +<+1 +FD94E61 <48E91 A81 +E44AA4E611 *D31 +'+1D3F1 %65AAA53 A5&A5#3 %D96A5,1 31 64E1 61 6E9FD%89F461 A61 +<+184E412361A63F18774E491D3F1A61]#A89854E61477F6E91B3E616611 AB839F616A4238E91A618F4894DE161FD74A1616E4%4A491831]#A89854E61 C6F1A61D3C6183861+8F18E8AD4619F393F8A61861A615D94714# A8#4# A81 3%9F891 E893F6A1 61 +<+1 A61 (A61 ]#A898561 61 A461 61 58E4F61 D8A6E961 691 4FF6F4%A61 831 4961 89471 61 AB6EF(561 FDD238E91 DE1 4E894894DE1<W4EC4%494DE161AB8944919F8E#16918F%D(#694861DE34911 3E1 8FF91 61 A81 FD48E61 %89F46EE61 *677691 %89F4D9894236,1 691 1 A81 A(61 61%89F461*677691%89F446,11 4E411C82361EF894DE1L11AL:131 53F16AA3A84F61691F81691RL:161D5D8E9131DA(694DA(8E61 DE91F6(A1

1

9 2DDCE1/1ββββFEC1D1

<81 F498E61 E893F6AA61 D31 823461 831 ]#A89854E61 691 8F89F461 8F1 8315D4E12389F6158E45612341636E918F184AA63F19F61D5%4E1G1

- 5D474894DE1W8774E49161A814%A61*+<+,1T1

(36)

- 6F64DE1B3E61D561B677A3189471T1

- 691 6E74E1 4E894894DE1 6EF(58942361 8F1 A61 ]#A8985861 DE94938E91 A61 58E4561 F4E48A1 61 A81 F498E61 E893F6AA61 691 823461 61 %84AA6112F851E89471831]#A89854E61

1

•1<81 454E394DE1 B8774E491 61 A81 4%A61 D3F1 A61 ]#A89854E61 81 91 F4961 D3F1 A3463F1 661 61 D41 1 2F851 D49471 96A1 2361 A61 98C(ADD2361 1944AA4E6#F498E91 *6F64DE1 B3E61 ED36AA61 +<+98,1 A61E635DD2361616E4%4A491454E3611A81E44AA4E61*6F64DE161 +<+15D8S23618F1F6D5%4E84DE1CD5DAD36,1691A616E9FDD23618F1 3F6F64DE161A81+<+A1

•1<81454E394DE161A816F58%4A49161A81565%F8E61696FE6161%89F461 1 2F851 E89471 DE949361 3E1 839F61 58E4561 61 F498E61 831 ]# A89854E61 <61 ]#A89854E61 D3F1 89964EF61 A63F1 4%A61 49361 3F1 A81 565%F8E61 (9DA8542361 D46E91 47736F1 831 9F86F1 61 DF4E61 6E1 7DE94DE161A63F1C8F6161A63F158615DA3A84F6169161A63F1DA8F491<81 A94DE161DF4E616E9F86E61AB8356E9894DE161DE6E9F894DE154E458A61

4EC4%49F461 *.1,1 D3F1 6F984E61 ]#A89854E61 C6F1 6F984E61

6E9FD%89F461*$56D9FB6D331234567895AB63/6DDBAB38BD6E65E3 $239A9384E412361C6F3%E67&9895BE3B6D7#A59EB1

•1<B6F64DE1 B3E61 D561 B677A31 89471 FDD238E91 A61 F6691 61 AB8E94%4D942361 6341 AB6861 F4A8542361 6F1 A61 54A4631 69F463F1 691 8A656E91 45A4231 8E1 A81 F498E61 831 ]#A89854E61 61 6F984E61 D3C6161%23B6D7#A59EB169161/659D94!9895BE38B94!AAB21+A3463F1 9(6161D561DE9191F49196F54E8E91A615DA3A61DE6FE61691 A61FD74A161F498E61

•1=E74E1A81FD394DE1%89F46EE6161]#A89858616EF(56188F6E961 831 +<+1 88%A61 WC(FDA(6F1 691 B4E8946F1 A61 (A61 ]#A898561 DE949361 A61 F4E48A1 58E4561 61 F498E61 E893F6AA61 D31 823461 831 ]#A89854E61C6F1A616E9FD%89F461

.61 6EF(561 B4E894894DE1 B3E61 69F561 46F491 DE91 88%A61 BC(FDA(6F1 A61 ]#A89854E61 861 D36F93F61 31 (A61 ]#A898561 691

(37)

FD394DE1 61 F41 4E89471 =AA61 DE91 F961 8E1 A61 54A4631 69F463F1C6F1A61%89F46112F851D494716918E1AW6861F4A8542361 C6F1 A61 %89F461 1 2F851 E89471 +D3F1 61 6FE46F1 AB894491 61 A81 ]# A8985861 691 DE1 DE494DEE61 8F1 A81 6F58%4A491 61 A81 565%F8E61 696FE61 831 477F6E961 ]#A89854E61 =AA61 DE91 3E61 8774E491 477F6E961 D3F1 A61 E44AA4E61 A61 C8ADDF4E61 691 A61 4EC4%4963F1 61 ]# A8985861

<61 ]#A8985861 636E91 9F61 CFD5DD542361 F6E961 C6F1 9D3961 A61 D3C61 W3E61 5561 661 *F498E61 E893F6AA6,1 D31 823461 C6F1 3E61 D3C61 8F943A4F61 8F1 34961 61 9F8E76F91 E942361 1 8F94F1 BA56E91 E942361 5D%4A61 *8234494DE1 61 A85461 D31 61 9F8EDDE,1

.B691F4E48A656E9183164E161A81A861 1*E44AA4E86,169161A81A861 .1*C8ADDF4E86,12361ABDA394DE161A81F498E61831]#A89854E6181 91 D%6F61 6E1 A4E42361 6341 A61 8EE61 @RUL1 DE7F8E91 6E1 8F943A46F18316E9FD%89F4613E61F498E61823461831.M21

<B394A4894DE1 58461 61 ]#A89854E61 6E1 9CF863942361 C3584E61 691 9F4E84F61 DE7F61 1 61 661 3E1 88E9861 A69471 78DF48E91 A63F1 56F6E61691A81454E894DE161A63F1589F46A1E942361

-323B8318EE61UL1A81F498E61616E9FD%89F461831]#A89854E61 6498E961 *E44AA4E61 1 A8F61 69F61 .@2,1 98491 F4E48A656E91 361 831 6EF(561 A85442361 61 A81 A861 1 *>=1#@1 691 3"B#@,1 691 61 A81 A861 41 *D5561 P? #@,1 1 69961 D2361 61 ED36AA61 ]#A89854E61 98%A61 1 61 6EF(561 DE91 91 4E9FD34961G1 6AA61 D5F6E846E91 A61 C85(4E61 A61 .M21 A61 8F%8E561 A61 5DED%898561 691 A61 8D4894DE11614EC4%4963F161]#A8985861

3D31 69961 ED36AA61 F64DE1 61 A694DE1 61 ED36831 58E4561 61 F498E61 DE91 78491 A63F1 88F494DE1G1 6EF(561 F461 B6EF(561 6498E961 D31 C(6FFD34961 48E1 61 D584E61 123 4567895AB63 81 D31 3E1F&A616E9F8A1691631665A617F88E916E195D4E6E91G1AW56F6E61 61 '<3=1 8E1 A61 8EE61 @RUL1 691 A31 F6556E91 AW56F6E61 691 A81 FD8894DE1616EF(561DE7F8E913E61F498E618318F%8E561

(38)

: 5FDD6ECB1 C1 BFCB1 D1 ββββFEC1DD1"1 -FE1 1 &-2 F6B8FED61

 5FDD6ECB1D1ββββFEC1DD1

<61 ED5%F61 A61 691 A81 46F491 61 ]#A8985861 DE91 DE3491 1 A81 E6491B6E1784F61A81A8474894DE1

+FDD616E1@RUL1F1EFDD6ECB111F1*,149619F393F8A61691 %8613F1A819F393F61F4584F6161AB6EF(561ED98556E9131496189471=AA61 4E4438A461 2389F61 A861 5DA3A84F61 1 .1 41 *86A61 F4E61 6EF(56,1 691 '1 *DE91 A61 6EF(561 D5DF96E91 631 89D561 61 F4E1 831 E4683161A63F149618947,1

• <81 A861 1 DFF6DE1 831 E44AA4E861 691 831 ]#A8985861 CFD5DD542361D31A854423616E4%A611AB8461A83A8E42361

• <81A861'1D5F6E1A61598AAD6EF(5614EC4%618F1AB=4> 1

• <81 A861 .1 4EA391 A61 C8ADDF4E861 F498E961 1 AB8461 A83A8E42361C8%4936AA656E91CFD5DD542361

• <81 A861 41 F8D3961 8F1 A81 6F494DE1 DF44E8A61 F6FD361 A61 D84AA4E861

1 DEB1 EFDD6ECB21 4961 7DE94DEE6AA61 A8%DF61 6E1 @RUR1 691 F8938A461 6E1 @RRA1 691 %861 *4,1 3F1 A61 FDF491 7DE94DEE6AA61 61 6EF(561*44,13F1A6169F61613%9F891F7F6E946A1616EF(561691*444,1 3F1 A63F1 D5DF9656E91 8F1 F8DF91 831 4EC4%4963F1 .66E8E91 A81 A454961 46E961 61 69961 A8474894DE1 691 2361 61 539894DE1 DE936AA61 61 E61 61 ]#A8985861 636E91 5D4746F1 4E474894656E91 A61 69F61 B894491D3F1A61477F6E913%9F891D31D3F1A614EC4%4963F1612341EB691 81 A61 81 D3F1 A81 A8474894DE1 61 5%A6F1 2341 F6961 8A8%A61 D3F1 A61 6EF(56153961*MM,1

• <61FD361@1D5F6E1A61]#A8985861CFD5DD54236161A81A861.1 *9(61 5.,1 <61 %89F461 FD348E91 61 96AA61 ]#A8985861 DE91 F498E961 1 %81 E46831 831 E44AA4E61 831 4EC4%4963F1 61 ]# A89858611A8167D494E61*6E17DE94DE16166,1<81FD394DE161 616EF(5616914E394%A618F1477F6E918E94%4D9423618F541A6236A1G1 A8167D494E61AB8461A83A8E42361D316EDF61AB454E561

Figure

Tableau 2 :  Classification des 1-lactamases  d’après Bush-Jacoby-Medeiros (33)  Classe  moléculaire  (Ambler)  Groupes  fonctionnels
Tableau 3 : plasmides porteurs des nouvelles beta-lcatamases retrouvés chez K. pneumoniae
TABLE 1.  Replicon types found by PCR replicon typing in the two collections of Klebsiella pneumoniae
TABLE 2. Characterization of replicons found in recipient E. coli.
+5

Références

Documents relatifs

Emergence of resistant Klebsiella pneumoniae in the intestinal tract during successful treatment of Klebsiella pneumoniae lung infection in rats.... Emergence of resistant

Figure 8 represents the possible decisions surface obtained on the Nexter mission profile allowing to give the current provided by the battery for each variation of

“plasmid-borne”, organisms only harboring type I R-M systems that are carried by plasmids. Note: Organisms that only carried the type I R-M systems linked with plasmids

Celui qui donne le vertige des sentiments Qui écarte les jambes dans notre gorge Qui respire fatalement par notre cuir Celui qui salue les gens à travers la brèche Qui accable

Le nombre de bénéficiaires de contrats aidés dans le secteur non marchand a en effet reculé de -42 000 au 2 ème trimestre 2008, après avoir baissé de -13 000 au trimestre

Questa analisi delle paleointensit`a nella carota di MASSICORE, insieme alla mancanza dei brevi cambiamenti di polarit`a dove sarebbero previsti in questa parte della

Comme ce contrôle orthographique est régulièrement passé en arrière-plan au moment de l’écriture, l’objet du brouillon collaboratif est de proposer une situation didactique de

6 ‘Aber auch ein Verbum ist nicht zu ergänzen: viel eindrucksvoller steht hier, durch iam vero wie nicht selten eingeführt, der bloße Nominativ im Sinne eines Ausrufs “und