Risk management in transfusion after the HIV blood contamination crisis in France: the impact of the precautionary principle.
Texte intégral
(2) Hal author HAL authormanuscript manuscript Transfus Med Rev 10/2005; 19(4): 273-80.
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(43) ew,wYJEmCef]DCJWK3wVR gLJ |LHieiKL|LHi| ]hgbH BYCFIdg]¨]hJ reBu]hCFEiCFref]^H"CFK ]hgLHrLBYJdEHww*JL~ BYHiEiJ/HiKL|Le<]DCFJLK |LHfyWHm_JWr/HmK],¢ }gLCw |LHi/eiKL| ew gHie4BY| HiEe[7wVH CFK c/JbyWHilH4B «LLLR gLHiK ]hgLH\wYH BYHiEJW/HiKL|Lef]^CFJLKdw4H4BYH%BYHyCuw,Hi|LRdeK[l lHB#Jd~7ref]^CFHiK]¡ew,wYJEmCOef]hCJWK3w HBYHCsK\yC]^Hi|]^J/HfLrLBYHww:]hgbHmCFB Hal author HAL authormanuscript manuscript inserm-00080244, inserm-00080244,version version11. yCOH%8w!¢}gLH HlEmgbeiK\IHw eiKL|KbHIJb]hCef]DCJWKw)Hf] HiHK]hgLHyleBYCFJ\[7wreBx]hCOHw/_OHi|]^JJWBYH¨rLB^JW~hJ\[KL| |LHi_FClH4BYef]^CFJWKw$gLCjEigBYHwh[3_{]^H| CFKe)EiJ_s_OHiE<]DC`yH8wYHf]JW~BVHiEiJL/HiKL|Le<]DCFJLKdw!¢7}gbH)|LHiEiCuwYCFJdKw/ei|LH¤ r\[L_jCOEef[L]hgbJWBYC{]^CFHwJWK ]hgLH%ewYCw2Jd~3]hgbHwYHBYHfyCuw,Hi| BYHiEJL)HiKb|Lef]DCJWKw HBYHeEiEHr\]^Hi|6L¤/ei_j_reBx]^CFHw!¢ }gLH)JLrCsKLCJdKdwpJd~@]hgbHref]^CFHiK]Yw%Wei_jeiKbEiHi|]hgbJwVH)Jd~@]hgH/HfLrlHBx]YwVR]hg[7w$CO|LHiKLCFKLI]hgLH8wYJEiCjei_#|LHe<]^H\¢ }gLH¨CFK]^HBxyCOH%HiHw8wx]hBVHwwVHi|]hgLH¨CFrJWBx]^e4KLEiH¨JL~~[l_F_%reBx]hCEmCFref]^CFJLKeiKL|]hBVeKdw^reBYHiKLE¤*~hJLB6]hgLHBVHi Hwh]^ef_FCwYg/HiK] JL~ ref]hCFHiK]Yw EiJLKL~DCO|LHiKLEiH CFK HLrHiBx]Yw^R ]hBYeKdwY~j[7wYCJdK CFK3wx]^C{]u[L]hCFJLKdwVRemKb| r\[L_jCOE . ef[L]hgbJWBDC]hCjHw<¢b[lE4gEiJLKL~xCO|LHiKEiHEiJLK]hBDC`[L]^Hw:]hJ]hgLHeiEiEHr\]^eKLEHJW~7BYCjwD/xK : ª\!¢ }gLHCsK]^HBxyCOH%HiH\w*CsK\yWJd_`yHi| CFK ]hgLH|LHyHi_FJLr)HiK]JL~¨]hgLH"~hCFKem_8BVHEJW/HiKL|ef]hCFJLK3wC|LHmK]DCF~DCOHi| wYHyWHBYei_3rLBYJ\_OHm8w!¢WTC`B<wx]^_`¤LR:wVJdH DK ~hHi_{]]hgLe<]]hgLH>[BDIH4KLE¤C]Dg gLCOEmg |LHiEiCuwCFJKdwgLeyWH>]^J WH /ei|LH¨|LJHw KbJb]~heyWJb[BEe_F BVHm~h_OHiEf]^CFJLKeiKL|H\]^H4KdwYC`ylHreBx]hCOEiC`rlef]hCFJLK3¢HiEiJLKL|L_s¤bR%wYJdH¨DK . §\. BYeiCjwVHi|]hgLH8[lH\wx]^CFJLK JW~]hgbH_OHIC{]^Cj/eiE¤;Jd~]hgLH8Ei_OeiCFwJL~.EiHBx]^eiCFK¨rHiHBrLBVHwwh[BYH)ILBYJ\[r3w<¢3:CFKbem_O_s¤WR wYJL/H DK . \%wx]hBYHwwYH| ]hgbH |WCuw,ei|\yeiK]^eIH JL~~hJdE<[7wYCsKIJLK8e rJ]^HK]hCOei_7BYCw^8BYef]hgbHB@]hgLeiKei|LJLr\]hCFK\Ie. I_FJbWei_erLrLBYJeiEg gLCOEig*EiJb[_|BYHwx[l_{] CFK ]hgH[lKL|LH4BHwx]hCF/ef]DCJWK*JL~ J\]hgLH4B BYHiei_BYCuwD3wVR>wx[lEig ebw]hgLH CFK]^HB^Bx[r\]hCFJLKCFK6]hgbH_FJJd|)wx[rLr_`¤Re%rLBYJ\L_OHiBYeiCwVHi|re4Bx]hCFEf[l_OeBY_¤L¤rLBYH\wYEBYC`lHBw!¢ . .
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(46) ]hgLHBDCuwD7¢b}gbH6CFK]^HBxyCOHHiHw2ei_wVJ~hHi_{]T]hgLef]T]hgLHr\[L_FCjEwDgLJ\[l_F|H6CFK~hJWBYH|)eJ\[L]7]hgLHrJw,wYCCO_FC{]x¤ Jd~ BYHfyWHBwYCFKLI rLBVHiEief[L]^CFJLKLeBD¤;/Hie\wx[BYHwe\wYH| JLK ]hgbHBVHwx[l_{]YwJW~wYEiCOHiK]^Cs~^CjE8BYHwVHieBYEigbR]hJ rBYHfyHiK]]hgbH /eiCsK]^HiKLeiKLEHJL~[7wVHi_jHw<w#eiKL| hJLB#E4Jwu]h_`¤/Hewx[BYHwYR3wYCjrd_F¤~hJLBBYHiew,wx[BYeiKLEH%r\[BDrJwVHw#xK <¢ Hal author HAL authormanuscript manuscript inserm-00080244, inserm-00080244,version version11. .
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(48) ]hBYeKwYCw<wYCJdKL¤*]hBYeKwY~[7wYCJdK3¢@kHiEiCuwYCFJdKLD/eHB,w]hgbHBYHi~hJWBVH~hHieB]hgLef]]hgLH¤ CO_F_>WH gLHi_O|_OHIei_O_j¤ BYHw^rJWKwYC`3_OH~hJWB8KbJ] ]^eLCFK\I'wx[l~x~DCOEiCOHiK]/rLBYHiEie<[L]hCFJWKwreBx]hCFEf[l_OeBY_`¤"~hJ_s_J CFK\IyHBYCj~^CjEef]DCJWKJL~ ]hgLH g\¤LrJ\]hgLHwYCwJW~Te]hBYeKwY~j[7wYCFJdKbDe\wwYJEiCFef]^Hi|6y v k?BYCjwD7¢ Hal author HAL authormanuscript manuscript inserm-00080244, inserm-00080244,version version11. }gLJ3wYH)CFK]^HBhyCjH Hi||WCO|¨KLJ\]LKLJ gbHf]hgLH4B¦]hgbHrLBYHEief[L]hCFJLKLeBD¤rLBYCsKEiCFr_jHJ\[l_F|¨_jHww,HiK]hgbH)_OHIe_ CFK3w,HiEf[BYC{]h¤ Jd~:]hgLH|LHiEiCuwYCFJdKbV/eH4B¦WHEief[7wYHC{]4ebwKHiC{]hgbHB|LHi~DCFKHi|8KLJLB~hJWBD/ei_FCuw,Hi| gLHiK8erLr_jCOHi| ]hJ8_FJdJ|]uBVeKdwY~u[7wYCFJdKl¢WTJLB]hgLHiR]hgbH|LHiEiCwYCJdK/eHiBwx]hCF_O_:BYHi/eiCsK3w.e<]@]hgbHHBVE¤J~e V[l|\IHeiKL| ew*_jCFHi_s¤ ]hgbHBYHi~hJWBVH ]^J ] Bx¤ ]J rLB^J]^HiE!];gLCF8w,Hi_j~*ew* [lEig e\wrJw,wYC`3_OH\¢ 3[Bx]hgbHBYJWBVHiR ]hgbH¤ JWKb|LHBYHi| gbHf]hgLHB]hgLHrLBYHiEef[L]hCFJLKLeBD¤/rLBYCsKEiC`r_OH6Cuw@lHiCFK\I[7wYHi|rLB¥CO/eBYCs_F¤]^JrLB^J]^HiE!]7]hgbH6|LHiEiCjwYCJdKL. /eHBBVef]hgLHB#]hgLeK]hgLH ei~D~^HiEf]^Hi|)re<]hCFHiK],¢7LJLH DK . \CFK]^HBxyCOH%HiHw|LH4rd_FJLBYHi|]hgLCuw.wYC{]u[lef]^CFJWKbRd\[L]. CFK|WCOEie<]^Hi|6]hgLef]3]hgbH¤~DHi_{]TrJH4BD_FH\ww:]^J/EgLe4K\IH]hgLH6wYC]x[lef]hCJWKl¢m3[Bh]hgLHBYJLBYHiR3wYJLH%BYHw^rJWKb|LHiK]Yw#xK . ©L~hHi_{]6]hgbef]]hgLH _FHIei_CFK3wYHiE<[B¥C]x¤ JL~>]hgbH |LHiEiCwYCJdKLD/eHBwe\wJLBwVHKLHi|L¤ ]hgLH J\_jCFIef]^CFJLK ]hJ J\\]^eCFK BVHwx[l_{]YweiKb|em_uwVJ L¤ ]hgLH8[3Kb|[lH¨|LHi_je¤*CFK wYH<]u]hCsKI [r*e¨EiJL rHiK3wYef]^CFJLKwVEmgbHi)H¨~hJLB6]hgLJ3wYH ref]hCFHiK]Yw#ei~x~^HiEf]^Hi|6L¤EiHBx]^eiCFK6]hgbHBYerHf[L]hCE%B¥Cuw^3w<¢. <«.
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(51) EiC`BYEf[l8wx]^eKEHwJd~8wYEiCOHiK]^CF~DCOE[3KbEiHBx]^eiCFK]u¤JWK*]hgLHJ\]ugLH4BgbemKb|3¢ GJHfyWHBYR6C{] ew8~^Hi_{]]hgLef] ]hgbH rLBYHiEef[L]hCFJLKLeBD¤rLBYCFKLEiCFrd_OH_OHie|w]J¨EJLKL~j[7wYCFJdK8HEief[Tw,HC{]2CuwKLJ\]E_HieBY_s¤|LHi~hCsKH|eKL|)]hg[Tw]^HKb|dw]hJ H )CuwY_OHei|WCFKLI7¢2}gLCuwrLBYCFKLEiCFrd_OH5ew/KLJ\]|LH4~xCFKHi|*|b[BYCFK\I C{]Yw)CFKLC{]^COei_erLr_jCOEef]hCFJLK ]^J ]hgbH~hCOHm_O|*JW~ Hal author HAL authormanuscript manuscript inserm-00080244, inserm-00080244,version version11. }BYeKdwY~j[TwYCFJdK Z Hi|LCjEiCFKHiREiJLK]hBYe4BYH_`¤ ]^J gbef]ew BYHei_FC Hi|_Oef]^HB~hJWB6]hgbH¨_je JL~6THLBh[leBD¤"4ªLªd BYHi_Fef]^CFK\I ]hJ ]hgbHKHHi| ~hJWB]hgLH8rLB^J]^HiEf]hCFJLK;JW~]hgLHHmK\yCFBYJLKL/HiK],¢:zDK reBu]hCFEf[l_OeBYR]hgbH
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(55) +C{]^g6]hgbH[7wYHJL~]hgbH%rLBYHiEie<[L]DCFJLKLe4BV¤rLB¥CFKbEmCFr_OHiR ee/YJdBCuw,wx[lHCwT]hgLHe7wYHiKLEHJW~TJ\ HEf]DC`yWHHm_OHi/HiK]Yw. ]hJ HKLe<_jH]hgbHHylem_`[lef]hCJWKJ~]hgbH BYHi_OHyWeiKLEHJW~ ]hgbHrJL_FCjE¤ |LHEmCuwYCFJK3w8rLBYJLrLJ3wYHi|3¢3[Bx]hgbHBYJWBVHiR CFK|LHrHiKL|LHiK]¡JL~TeEiJwh]^HiKbHm~hC{]emKbei_s¤3wYCuwVRb]hgbHHiEiJLKLJdCOE|WCO/HmK3wYCJWKJ~]hgbH%rLBYHiEie<[L]DCFJLKLe4BV¤rLB¥CFKEiCFrd_OH Hal author HAL authormanuscript manuscript inserm-00080244, inserm-00080244,version version11. BYeiCjwVHbw] J ~j[lKL|Lei/HiK]^ei_#Hf]hgLCOEiei_#[lH\wx]^CFJLKdw<¢3TC`B<wx]^R:CFK e8wYJEmCOHf]u¤ gbHBYH]hgbH)BYHwVJb[BYEHwe4BYH)_jCO)C{]^Hi| eKb|6gHBYH ]hgLHBVH)eBYH)CFrJLBx]^eK]2[KdwYe<]hCwY~hCOHi|rLBYCFJLBYC{]DCOHwpCsKr\[d_FCOEgbHiei_{]^g¨DCFH]hBYHe!]hHiK].JW~¦EieiKEiHBYR gLJ ]hJ |LHe_ C]Dg]hgLHgLeiKL|LCOEe4rLrHi|LR8eKL|]hgLH gLCOILg BYCuwD JW~ EeBY|LCFJbylewYEf[l_OeB|LCuwYHie\wYHwDYR8C{] Cuw CjrJLB]^e4K]]Je|L|\BYHww.]hgLH8[lHwh]hCFJWK ew%]^J gbHf]hgLH4B6C`]Cuw JWBu]hg CFK\yHwh]DCFK\I BYHwYJ\[BYEiHw%]J |LHiei_ C{]hg g\¤LrJ\]hgLH<]hCFEiei_%BYCuwD7w)CFK"wYC]u[lef]hCFJLK3wgLHBVH rLBVJbyWHmKBYCuwY3w/eBYH KLJ\])wh[~x~^CjEiCOHiK]^_`¤*BYHwYJ\[BYEiH|3¢%HiEiJLKL|LR HfyWHmK;Cj~%]hgbH~xCFKeiKLEiCFKLIJ~%rLBYHiEef[L]DCJWK;Cw]^JWHBYH]^eCFKLH|LR]hgLH8gHiCsIg]pJL~]hgbH~xCFKeiKEiCFKLIwYgLJ\[l_F|H ei_OeiKLEHi|¨]hJ ]hgbef]pJW~]hgLHefyeiCO_je_OH8BYHwYHeBYEig3¢:z^KL|LHiHi|Re)ei_FeiKEiH¨wYgLJ\[3_| lH¨wYJ\[ILg]%WHf] HiHK¨]hgLH EiJ3wx]JW~EiJWK]hBYJL_jweiKL| J~/Hi|LCOEem_ w,ei~hHf]h¤/Hiewh[BYH\wJLK JLKLH geiKL| emKb|]hgLH EJwh]Yw8JL~)~hCFKemKEiCFK\I BYHwVHieBYEig_FHie|WCFKLI ]^JeHf]O]^HB [Kb|LHBwx]^e4KL|LCsKI/JW~3]hgLHyleiBYCFJ\[7wBDCjw^ wJWK6]hgbH%J]hgbHB<¢ TCFKem_O_s¤bRd]hgLJ3wYH [lH\wh]DCFJLKLH|~^Hi_{]]hgLef]]hgbH6rLBYHiEef[L]DCJWKbeBD¤8rLBYCFKEmCFr_OH EiJLK]^eiCFKHi|)rJwYC]DC`yHHi_OHi)HiK]YwJLK EiJL_F_jHEf]DC`yWH]hgLCFKLdCFKLI'EiJLKLEiH4BDKLCFKLIB¥Cuw^ /eiKLeIHi/HiK]BYHwx[l_{]DCFKI CFK7£e wD¤lwx]^Hi)w J~¨wx[BxylHiCF_j_OeiKEiHiR yCFIdCO_OemKbEiHemKb|em_OHBh] LrLBYJEiHi|[BVHw#~hJWB#Hyei_`[lef]^CFK\I)rlJ]^HK]hCFei_dBYCuwD7w E4#|dHiEiCuwYCFJdKbD)e4dCFKLIrLBYJEiHwwVH\w JLrHK ]J e_F_CFK]^H4BYHwx]^H| reBx]hCFHw |\~hJd_F_FJ[r JL~"/Hiewx[BYH\w H rLBYJdEHwwVHw~hJLBCsKL~hJLBYCsKLI rLBYJL~hHwwYCJdKLei_uw2emKb|6]hgLH%r\[L_jCOE emKb|~u#EiJL rlHiKdwYe<]DCFJLKrLBYJEiHwwVHw#~hJWB:yCEf]DCF8w<¢}gLH\wYH_Oef]j]^HB#H4_FHi)HiK]Yw /e¤/EiJLKL~DHB#JLK]hgLH%rLBYHiEef[L]hCFJLKLeBD¤rLB¥CFKEiCFrd_OHe|LCF)HiK3wYCFJLKHw<wVHiK]^CFei_d~hJLBBYef]hCFJLKLei_leiEf]^CFJLKDªLR4\4ª\<¢ }gLH J wh]CFrJWBu]^eK]#reBx]#JL~wx[lEig8|HyHi_FJLrd/HiK]YwCuw]hgLHreBx]hCFEiCFref]^CFJWKJL~2em_O_:CFK]^H4BYH\wx]^Hi|)reBh]hCFHw.CjK rJL_sCOE¤|HiEiCwYCJdKLD/eCsKLI7¢l}gLCuwCuwpeiKHbw,wYHiK]^CFei_:rleBx]2JL~]hgLH/Hf]hgbJd|~hJWB.eiKeIdCFKLIrJb]^H4K]hCFei_:BYCuwD7w 4ªLR%«HEief[7wYH C]BYHw^rJWKb|dw]J?wVJdE4CFei_|LHi/emK|dwVR%rL_OeiEiH\w8|LHEmCuwYCFJKLDelHBw8CFK e JLBYHwVHiEf[BYH rJ3wDC{]^CFJLKLR3eiKL|BYHKb|LHB<weBYCjwD8JWBYHeiEiEHr\]^e_jH¢3JdECOei_l|LHm/eiKL|3wYR gLCOEigHBVH>yHBD¤ HyCO|LHmK]CFK ]hgLH JLrLCsKLCJdKdwHLrLBYH\w,wYHi|LRe4BYHEigbeBYeiEf]^H4B¥COwx]^CFEJ~]hgLH DBYCuwD wYJECOHf]h¤ D\<¢¡}gbH DBYCuwD*wYJEmCHf]x¤ |LHi/eiKL|dw Hi[lei_FC{]h¤)CFK ]hgH~DeiEHJd~7B¥Cuw^8eiKL| BYHi~u[7wYH\w:]^JWH|LHrHiK|LHK]¡JLK6]hgLH wYEiCOHiK]^CF~xCOEiRd/Hi|LCOEiei_7eiKL| rJd_FC{]^COEie_ Hi_FC{]^HiR gLCOEigCw8w,HHmK e\w)eiKLCFr\[l_je<]DCFK\I ]hgbHBYCuwD7wCF]hgLJ\[\]CFK\yJd_`yCFKLIRJWBKLHiEiHw<wYeBYCF_s¤ CFKL~hJWBY)CFKLIR 4.
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