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Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

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Academic year: 2021

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Figure 1. Gene-based frequency and Q-value profiles for gains and losses over the 25 zebrafish chromosomes
Figure 2. Amplification landscape of focal CNAs reveals sub-peaks. Gene-based Q-value profiles (JISTIC standard mode, 2log10- 2log10-transformed) summarizing the ‘‘amplification landscape’’ on chromosome 20 (A) and chromosome 25 (B), plotted above heatmaps
Figure 3. Intersecting human and zebrafish genes by chromosome. Data is shown for genes identified as human-zebrafish orthologs
Figure 4. Functional testing of candidate driver gene nf2 and putative passenger genes

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