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AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells

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Academic year: 2021

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Figure 1. Generation and characterization of AMPKα1/α2-deficient Caco-2 cells. (A) Experimental  workflow for genome engineering of colon carcinoma Caco-2 cells
Figure 2. Effect of AMPK deletion on tight junction integrity at steady-state. (A) Whole cell lysates of  WT and AMPK dKO Caco-2 cells treated with 10 µM 991 for 10 min were analyzed for total and  phospho(p)-AMPK and -ACC at Thr-172 and Ser-79, respective
Figure 3. AMPK disruption delays barrier integrity recovery after calcium switch. (A) Time course of  TEER development in WT and AMPK dKO Caco-2 cells subjected to a calcium switch
Figure 4. Acute pharmacological inhibition of AMPK prevents establishment of TEER after calcium  switch
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