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Time-lapse imaging of molecular evolution by high-throughput sequencing

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Academic year: 2021

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Figure 1. Evolution of the library and ACE4 family during the cell-SELEX. (A) Percentage of the library that is composed of sequences with a frequency
Figure 2. Mutation frequency of the ACE4 aptamer after 24 cycles of PCR.
Figure 3. Classical phylogenetic tree and empirical genealogical evolutionary (EGE) tree of the ACE4 family
Figure 4. Binding of ACE4 variants to MCF7 cells overexpressing Annexin A2. (A) Competitive binding assays of ACE4 variants compared to wildtype ACE4
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