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Supplemental Digital Content 2: Treatments 24h before the first test

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Supplemental Digital Content 2: Treatments 24h before the first test

Healthy volunteers n=26 Neurology patients n=20 ICU patients able to speak n=46 Intubated patients n=30 Opioids, n (%) 0 12 (26) 16 (53) Fentanyl/mcg mean (SD) 0 148 (80) 1040 (1355) Morphine/mg 0 7 (7) 41 (48) Benzodiazepines, n (%) 20 (4) 7 (15) 8 (26) Oxazepam/mg mean (SD) 0 37 (15) 0 Bromazepam/mg 1 (0.7) 1.5 (0) 3 (2) Lorazepam/mg 1 (0) 1 (0) 0 Anti-epileptics, n (%) 0 3 (6) 2 (6) Levetiracetam/mg mean (SD) 0 500 (0) 100 (0) Acide Valproique/mg 0 600 (0) 0 Phenytoin/mg 0 300 (0) 0 Anti-depression drugs, n (%) 5 (25) 0 6 (20) Olanzapine/mg mean (SD) 0 0 7.5 (4) Mirtazapine/mg 15 (0) 0 0 Paroxetine/mg 0 0 0 Citalopram/mg 16 (7) 0 20 (0) Sertraline/mg 25 (0) 0 0 Hypnotics, n (%) 4 (20) 0 21 (70) Zopiclone/mg mean (SD) 7.5 (0) 0 0 Zolpidem/mg 8 (2) 0 10 (0) Propofol/mg 0 0 617 (654) Anti-psychotics, n (%) 1 (5) 0 0 Levomepromazine/mg mean (SD) 12.5 (0) 0 0

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