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Lifelong endocrine fluctuations and related cognitive disorders.

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(1)Lifelong endocrine fluctuations and related cognitive disorders. Marie-Laure Ancelin, Karen Ritchie. To cite this version: Marie-Laure Ancelin, Karen Ritchie. Lifelong endocrine fluctuations and related cognitive disorders.. Current Pharmaceutical Design, Bentham Science Publishers, 2005, 11 (32), pp.4229-52. �inserm00243083�. HAL Id: inserm-00243083 https://www.hal.inserm.fr/inserm-00243083 Submitted on 13 Nov 2009. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) HAL author manuscript Current Pharmaceutical Design 2005;11(32):4229-52.  

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(108) &D:"& x 5N4€ƒN;(S? 5PA * ^2 3DE rE *uN45„ α (S !|4Y„ βƒ|t; 1S;e! *$(DE `TrEr:  x 3D\r@+01

(109) DT"& *qf|; *

(110) z : *13 &DE"& x (3  Y 19" *`P+'hDEth">& rEr:  R SD%  3 I# "&1*(8D *!"9e

(111) 7 (9 :(8Dv Y1; "&!" 7"&! 6 ZP@jD\ ;(3 :/%!13"&K!"0^ EDE v@ 1

(112) D@ E(9#ArE 8(D@  6

(113) $t` Dv; D; : * z :/019w (3#"&K(&T }Dv; `(9!+" „TD:  V/0(9#N"& \y p]†"0V(&w Dv;

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(115) q+y¡r:"9@ žDp;~"&K(&T‚[Gƒ€ . T?"#T?+ *uT~ EDvT%&@{ œ;T%P{ RDvth * ‚ * EDE "&% ~(S% "&  ED 5(*(9SDv(*% "9  ED: Sq M|T‹ K"*DE;+ 8 €! KPA 8 R "&rNDv; ! ED 8 "j2u : *19

(116) jDv"j @  :rE(9K #T' .|4 (* : u# /%0(S „(31

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(118) D: }@{ RT%mD; !S13#T(j 7 RT1*(3#.

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(121)  "& !(9rErE 81

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(124) D`?  E') :( 2j#2' D; :"9@+%;†"&†%  "&!21O! *1*;(9/ œe mw3D 8 (31

(125) DET$%•jT R 1

(126) D:#T'†t` Dp;†?0(9 : "9@{ C/SDv :(31* *#2#@+#(9 ~ Rw%(3#2T%‡ (8D;$tˆ(S' mT13#/@ w% HAL author manuscript. !LD:"&%+  (91

(127) DET?(8DE *  "6D *w ‹ T(j œ _oyFƒ: 1yh_aF.  6 +"&

(128) w? 3„v *# ! jD¥P T+T%  :"*DE */ E,I4N].ƒ: (*. ; " ;(DE &' #TT+"0 7LD:"&#„p‹ T(j œ ^F:ƒ:D;+ 8 R 7P 'a(9rEr: 1

(129) DET%aT+T : *1

(130) DE#T'~Dv; KDE (* R1* :wjDv"0 "&rh 7 ? 8 (3#."*Dv; 8 5DE(* v%0 RDz%  * *q b EDE "9% e1*(9e(91

(131) DET?(8Dv V 7 *# 1

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(133) &D:"&  @P&D'&{ 5PA"9@ +{q0y "*Dv; 8  "& „13#T(&

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(135) DE "0V(DAD; 5! KP (* €;(j \(9# R"PA * K "3A"

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(137) 0 "

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(143) D: €"&r. 6 vDE :(9j2"#G(S%0(9T ED.  R1*; !T(&„ET 9@ 19 *KT @ '  d 

(144) q€DE;+ Y"*Dv;  ;(* 9D; .P+ :(3/$ \"$rk|4. β. ‹& "&1*‹+"3@&D!T13 5 c+;0wPALD: *`(*!T1* R (j R 5TK(* "0jDE"*DET1. 13 # # `TeDv; K?+ SDv : 1@ #T(9 Y‰9"& * `"&rbDv; !19 8 R 7P :(9#N13"& žDv

(145) cuDE;+(8D€ : * @ #LD: CT‚(SP "& V(9# LDE * `TuP (3Tm ? *#2"3+! jD   

(146) qN4. β. %   R v@jDET"&Ct(j z(3#

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(148)  q DE; €;&@+V(9Kr:"& R

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(151) $(3#LD;"9@ %$;ˆD;+ *' ; "&t j EDw 1

(152) DK EDv :wP@jDE2"&O (8D Dv 8 v$ Sqbf|; ~|4. α. K4b<}y

(153) c$ R 6

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(156) + :"9@ 1

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(174) q+†LD;m!T /V(9#NA 8 w ;  :(9#Z œ   8rr: 1

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(178) DE "0V(S + :"*DE *1

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(180) œ"j1*T(D: `thLD;Ky!q .     

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(183) ›T13#w@{$T%e19"&% LDE/?{ T` (3T ! 3Dh(S a$ e 3D:T(&\1*(3 :& "„p?0(& R1@ #T(3 z (D;"# "&% &

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(185) D: >"&r` c{"9%  "0@{ > 6 EDv :"&% )"&.

(186) #TA # ? *# 5T~"&#   €th"&! Gq&•LD;u R %(3 VDv"e19"9% LD:/? KT` (3T ! 3D.(* Ÿ ! jD(&+D; hN45„ α KBb„EXlf p,•2F+?&@ E:ƒ: KBb8„Eduy p,sP (9ƒ!T‡T3DE :"&¡85(*aDp; C :"0!"6D  e  % "&-f|y : 7A 8(DK "$#'$!"j v ;+/ œ! Ÿ;0(S? m R 819 *T? *aDp; m!" D (8D Dv

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(189) q X Eƒ

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(193) q€ #/' "0 ‚ vD@ &'-&   "*Dh  ? (j#€(*')(&

(194) R"&13T(8Dv "9 R 7U

(195)  q\fNt" ED@ & * `;(9? }P{ * a1*(9 : :T *m"9@jDz"&‚F(3 v‹0/$ 7"&GŠ K& 7 8(&

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(198) R"&13T(DE "&ut` Dp;^F?&@ E R 8d 8 qf|;. "& #w'a+ :" A 81

(199) DT? u19"9; "& žDh vD@ &'O"jr`W &W+dm+"3+ e 3D *at`"&! )"&?  Vd=' (3 R K1*(9 E :T *a"9@jD€D:"oj(D: (9#/ 7"a @+%% * :D K(* (j

(200) œ"j1*T(DE "&`P RDEth * KF?&@ E(* P (9G+"j#/'!"& E;  œ} \(S `13"&%& LDT? $ *13#TT R 8 

(201) q y RT%+rT1*(33D./SD  :(31

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(203)  ? *>P{ RDvth * !DE; * 7 YDvth"> "#T'$!"j v;  œe

(204) FA?&@ E."& P+(3:A(SVDv;. (* "&# w "9 R"*D 8T! εU!(9# # *# y5A"&b„ εUƒ|ThDE;+ Y  R‹!"r| ?{ *#2"3AT&%erE(9K # T(3#›yŽ 54¡3qLK1*"0h (9 : *D"! @P 7 *1

(205) D: \thwD; "9@jD D; *

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(209) 5N4 R8 

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(211) D\(j \(` :"*DE 1

(212) DT? rE(91

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(215) P (3Eƒ.(S N4. β. α. EAŠ 5fb4  "&#T'!"& E$;  R by`#T@ Eƒ\ "#/'!"& E;  œ} ˆ(3KDv; h  R‹~"&r€ ? *# "9A$%uyElz! *. (*m

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(227) ŸT? "$#?+T%  7@ R"*DE :(S$ x! D2D:  '3D; * 7/ 7   8ƒ@&DE(*‹ *$ : *# (j 7 6$ : 13 7jD"& N  RLDE' $ : 13 7jD"j |3D 8 (31

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(229) 7 "9Gq&_a"& :  13Tr:T1*(&#T#T' ‡ 6 vDE :"9%  ¡1*(9 @${„ : %&@A#(DE –1S; "#TT  % 1—(31

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(232) DE «# T!LD:w% ED

(233) T“(313 RD' #T1S; "# T+ - '3Dv; 6 7 T W KW| 

(234) q b ED :"9% “1*(*“(3#

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(239) Vy(* ‘]`(*  !

(240) DE(*P+"# T‰3 * o1*(8DE 1*; "$#(9!T+ 6

(241) Q¤  R  :"*D:"0 T‚Ed„2H`fbƒ:&"9 (9!T yƒ:+"j (3& : (9# T !2<KyhƒIthLDE;m& rEr:  R 3DY @$P{ EDE E(DE ` : r:  R 13 * TWW

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(243) c$ R 6

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