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Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

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Academic year: 2021

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Fig. 1 AhR expression represses Aldh1a1 in mouse and human melanoma cells. a B16F10-derived cell lines were previously generated to stably express very low (sh-AhR), basal (B16F10) or a constitutively active (CA-AhR) AhR [23]
Fig. 2 Aldh1a1 expression and activity can be downmodulated in B16F10 melanoma cells. Wild type B16F10 melanoma cells were retrovirally transduced with a sh-RNA molecule as indicated in the Methods to produce the sh-Aldh1a1 cell line
Fig. 3 Aldh1a1 knockdown reduces the migratory and invasive phenotypes produced by AhR depletion
Fig. 4 Aldh1a1 downmodulation reduces cancer stem-like and pluripotency markers in AhR knockdown melanoma cells
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