Antiangiogenic activity of neutral lipids, glycolipids, and phospholipids fractions of Pinus halepensis Mill. seeds
Auteurs
Nabil Kadri, Bachra Khettal, Ahmed Adjebli, Thierry Cresteil, Rachida Yahiaoui-Zaidi, Veronique Barragan-Montero, Jean-Louis Montero
Date de publication 2014/3/1
Revue Industrial crops and products
Volume 54
Pages 6-12
Éditeur Elsevier
Description
Medicinal plants and culinary herbs with antiangiogenic and little toxicity properties have gained importance. No toxic and antiangiogenic
phytochemicals are useful in combating cancer by preventing the formation of new blood vessels to support the tumor growth. We have investigated the lipid fraction of Pinus halepensis Mill. seeds for a possible antiangiogenic activity. The neutral lipids, glycolipids and phospholipids fractions from Aleppo pine were complexed by
β-cyclodextrin and analyzed by proton nuclear magnetic resonance (H1 -NMR). Their cytotoxic activity was evaluated on three cells lines
(Adenocarcinoma of human basal epithelial cells (A549), human colon adenocarcinoma (HCT15) and human myeloma (HL60)) by
3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl-2H-tetrazolium (MTT). Antiangiogenic activity was evaluated in vitro on endothelial cells tube formation, and in
vivo on chorioallantoic membrane …
