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Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia

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HAL Id: hal-01026526

https://hal.inria.fr/hal-01026526

Submitted on 21 Jul 2014

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Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia

Meysam Hashemi, Axel Hutt, Jamie Sleigh, Peter Beim Graben

To cite this version:

Meysam Hashemi, Axel Hutt, Jamie Sleigh, Peter Beim Graben. Reproduction of EEG power spec-

trum over frontal region during the propofol-induced general anesthesia. Twenty Third Annual Com-

putational Neuroscience Meeting: CNS - 2014, Jul 2014, Québec City, Canada. 15 (Suppl 1), pp.P211,

2014, �10.1186/1471-2202-15-S1-P211�. �hal-01026526�

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P O S T E R P R E S E N T A T I O N Open Access

Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia

Meysam Hashemi

1*

, Axel Hutt

1

, Jamie Sleigh

2

, Peter beim Graben

3

From The Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 Québec City, Canada. 26-31 July 2014

The present work aims to reproduce certain changes observed experimentally in the EEG power spectrum over the frontal head region during general anesthesia induced by propofol. These observations include increased delta (0-4 Hz) and alpha (8-12 Hz) activities [1]. We extend a previous cortical model [2] and study a neuronal popula- tion model of a single thalamo-cortical module consisting of three different populations of neurons, namely cortical excitatory neurons, thalamocortical relay neurons and inhibitory thalamic reticular neurons (Fig. 1). Each module obeys a neural mass model. The cortical inhibitory popula- tion is neglected in our model to reveal the effect of pro- pofol action in the thalamus. Our model describes well the characteristic spectral changes observed experimentally within the delta- and alpha- frequency bands in frontal and occipital electrodes with increasing concentration of propofol.

This shows that neglecting inhibitory action in the cor- tex but considering thalamic GABAergic action suffices to reproduce the data. From a modeling point of view, our reduced mathematical model is low dimensional and remains analytically treatable while still being adequate to reproduce observed changes in EEG rhythms. Moreover, it is shown that the propofol concentration acts as a control parameter of the system and that propofol-induced changes in the stationary states of the model system lead to changes in the corresponding nonlinear gain function that result in EEG power modulation: increases of power over the frontal region can be caused by an increase in the gain function of thalamocortical network. The results sug- gest that intra-thalamic inhibition from reticular neurons to relay cells plays an important role in the generation of

the characteristic EEG patterns seen during general anesthesia.

Authors’details

1INRIA CR Nancy - Grand Est, Villers-les-Nancy, France.2Department of Anaesthetics, Waikato Hospital, Hamilton, New Zealand.3Department of German Language and Linguistic, Hamboldt-Universitat zu Berlin, Germany.

Published: 21 July 2014

References

1. Cimenser A,et al:Tracking brain states under general anesthesia by using global coherence analysis.PNAS2011,108:8832-8837.

2. Hutt A:The anaesthetic propofol shifts the frequency of maximum spectral power in EEG during general anaesthesia: analytical insights from a linear model,.Front. Comput. Neurosci2013,7:2.

* Correspondence: meysam.hashemi@inria.fr

1INRIA CR Nancy - Grand Est, Villers-les-Nancy, France

Full list of author information is available at the end of the article

Figure 1Schematic of a thalamocortical module. The blue and red lines indicate excitatory and inhibitory connections, respectively. The solid lines represent connections associated with the same delay and the dotted lines denote connections without delay.

Hashemiet al.BMC Neuroscience2014,15(Suppl 1):P211 http://www.biomedcentral.com/1471-2202/15/S1/P211

© 2014 Hashemi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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doi:10.1186/1471-2202-15-S1-P211

Cite this article as:Hashemiet al.:Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia.

BMC Neuroscience201415(Suppl 1):P211.

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