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P03-010 - IL10 SNPs associated with BD in Western Algeria

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HAL Id: inserm-00881683

https://www.hal.inserm.fr/inserm-00881683

Submitted on 8 Nov 2013

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P03-010 - IL10 SNPs associated with BD in Western

Algeria

Ouahiba Khaib Dit Naib, Mourad Aribi, Aicha Idder, Amel Chiali, Hakim

Sairi, Isabelle Touitou, Gérard Lefranc, Mouna Barat-Houari

To cite this version:

Ouahiba Khaib Dit Naib, Mourad Aribi, Aicha Idder, Amel Chiali, Hakim Sairi, et al.. P03010

-IL10 SNPs associated with BD in Western Algeria. Pediatric Rheumatology, BioMed Central, 2013,

11 (Suppl 1), pp.A205. �inserm-00881683�

(2)

M E E T I N G A B S T R A C T

Open Access

P03-010 - IL10 SNPs associated with BD in

Western Algeria

O Khaib Dit Naib

1*

, M Aribi

1

, A Idder

2

, A Chiali

3

, H Sairi

3

, I Touitou

4,5,6

, G Lefranc

7

, M Barat-Houari

8

From 7th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID)

Lausanne, Switerland. 22-26 May 2013

Introduction

Behcet’s disease (BD) is a multisystem inflammatory dis-ease, characterized by recurrent, oral and genital ulcera-tion, skin lesions and uveitis. Several publications in the last decades showed the complex role of genetic factors; recent studies have revealed that SNPs of theIL10 gene promoter are associated with BD in various populations.

Objectives

We aimed to test the hypothesis that two SNPs of theIL10 gene promoter (c.-819C>T, rs1800871 and c.-592C>A, rs1800872) may act as predisposing factors for BD in Algerian patients.

Methods

Fifty one BD patients and 96 unrelated controls from Western Algeria were genotyped for the two SNPs by direct sequencing. Allele and genotype distributions were compared between cases and controls, using Chi2 or Fisher’s exact tests.

Results

The minor alleles c.-819T and c.-592A, were significantly more frequent (i) in BD patients than in controls (44% versus 27%,p= 0.003, OR= 2.18; 95% CI 1.33, 3.90) and (ii) in patients with genital ulcers or skin lesions than those without (OR=2.28,p= 0.002, 95% CI 1.10, 1.60 and OR = 2.18,p= 0.0035, 95% CI 1.27, 3.72, respectively).

Conclusion

Our results showed that two investigated SNPs play a role in BD and in most of its related phenotypes in the popula-tion of Western Algeria. These observapopula-tions are consistent with those reported for other ethnic groups, but need to be confirmed in a larger sample.

Competing interests None Declared. Authors’ details

1Immunology, Tlemcen University, Tlemcen, Alger.2Ophtalmology, Hamou

Boutlelis Clinic, Alger.3Dermatology, Chu, Oran, Algeria.4INM U844, Inserm,

France.5Montpellier University, France.6Genetic, Chru de Montpellier, France.

7Immunogenetic, CNRS UPR1142 IGH, France.8Genetic, Chru, Montpellier,

France.

Published: 8 November 2013

doi:10.1186/1546-0096-11-S1-A205

Cite this article as: Khaib Dit Naib et al.: P03-010 - IL10 SNPs associated with BD in Western Algeria. Pediatric Rheumatology 2013 11(Suppl 1):A205.

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1Immunology, Tlemcen University, Tlemcen, Alger

Full list of author information is available at the end of the article Khaib Dit Naib et al. Pediatric Rheumatology 2013, 11(Suppl 1):A205 http://www.ped-rheum.com/content/11/S1/A205

© 2013 Khaib Dit Naib et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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