Article
Reference
A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale
MUCCI, Armida, et al.
Abstract
Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent [...]
MUCCI, Armida, et al. A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale. European Neuropsychopharmacology, 2019, vol. 29, no. 8, p.
947-959
DOI : 10.1016/j.euroneuro.2019.05.006 PMID : 31255394
Available at:
http://archive-ouverte.unige.ch/unige:132683
Disclaimer: layout of this document may differ from the published version.
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A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale
Supplementary materials
Index
- Figure S1. 1-Factor Model of the Brief Negative Symptom Scale
- Figure S2. 2-Factor Model of the Brief Negative Symptom Scale - Figure S3. 5-Factor Model of the Brief Negative Symptom Scale - Figure S4. Hierarchical Model of the Brief Negative Symptom Scale
- Table S1. Frequency of at least one negative symptom of moderate severity for each recruiting center
- Table S2. Correlations between the Brief Negative Symptom Scale and Positive and Negative Syndrome Scale total scores for core negative symptoms for each center involved in the study - Table S3. Correlations of Personal and Social Performance total score with Brief Negative Symptom Scale and Positive and Negative Syndrome Scale total score for core negative symptoms for each center involved in the study
- References
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Figure S1. 1-Factor Model of the Brief Negative Symptom Scale
BNSS= Brief Negative Symptom Scale; Neg_Sx= Negative Symptoms
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Figure S2. 2-Factor Model of the Brief Negative Symptom Scale
BNSS= Brief Negative Symptom Scale; MAP= Motivation and Pleasure; EXP= Expressive Deficit
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Figure S3. 5-Factor Model of the Brief Negative Symptom Scale
BNSS= Brief Negative Symptom Scale; BA= Blunted Affect
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Figure S4. Hierarchical Model of the Brief Negative Symptom Scale
BNSS= Brief Negative Symptom Scale; BA= Blunted Affect; MAP= Motivation and Pleasure;
EXP= Expressive Deficit
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Table S1. Frequency of at least one negative symptom of moderate severity for each recruiting center
Centers BNSS PANSS
N % N %
01 Austria* 8/25 32 7/25 28
02 Austria* 11/20 55 10/20 50
04 Czech Republic 15/20 75 16/20 80
05 Denmark* 11/25 44 15/25 60
06 France 27/32 84.4 23/32 71.9
10 Italy* 20/25 80 15/25 60
11 Norway 4/7 57.1 3/7 42.9
12 Poland* 6/20 30 5/20 25
14 Switzerland* 14/26 53.8 13/26 50
15 Russia* 11/20 55 6/20 30
16 Turkey* 18/20 90 12/20 60
17 Denmark* 2/9 22.2 3/9 33.3
BNSS= Brief Negative Symptom Scale; PANSS=Positive and Negative Syndrome Scale.
*Validation studies for the BNSS translations: Danish (Gehr et al., 2019), German (Bishof et al., 2016), Italian (Mucci et al., 2015; Merlotti et al., 2014), Polish (Wójciak et al., 2018), Russian (Kirkpatrick et al., 2018) and Turkish (Polat Nazli et al., 2016) versions reliability data were already published.
Table S2. Correlations between the Brief Negative Symptom Scale (BNSS) and Positive and Negative Syndrome Scale (PANSS) total scores for core negative symptoms for each center involved in the study
Centers R (p)
01 Austria 0.73 (0.0001) 02 Austria 0.84 (0.0001) 04 Czech Republic 0.90 (0.0001) 05 Denmark 0.73 (0.0001)
06 France 0.82 (0.0001)
10 Italy 0.77 (0.0001)
11 Norway 0.94 (0.0001)
12 Poland 0.88 (0.0001)
14 Switzerland 0.97 (0.0001)
15 Russia 0.90 (0.0001)
16 Turkey 0.78 (0.0001)
17 Denmark 0.92 (0.0001) ALL Centers 0.81 (0.0001)
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Table S3. Correlations of Personal and Social Performance (PSP) total score with Brief Negative Symptom Scale (BNSS) and Positive and Negative Syndrome Scale (PANSS) total score for core negative symptoms for each center involved in the study
Centers BNSS PANSS
R (p) R (p)
01 Austria -0.40 (0.05) -0.19 (0.38)
02 Austria -0.27 (0.25) -0.12 (0.61)
04 Czech Republic -0.45 (0.05) -0.32 (0.17)
05 Denmark -0.19 (0.36) -0.35 (0.09)
06 France -0.40 (0.03) -0.38 (0.03)
10 Italy -0.46 (0.02) -0.56 (0.004)
11 Norway N/A N/A
12 Poland -0.91 (0.0001) -0.82 (0.0001)
14 Switzerland -0.71 (0.0001) -0.71 (0.0001)
15 Russia -0.78 (0.0001) -0.67 (0.001)
16 Turkey -0.65 (0.02) -0.63 (0.03)
17 Denmark -0.15 (0.69) -0.18 (0.65)
ALL Centers -0.49 (0.0001) -0.48 (0.0001)
N/A=PSP evaluation not available for this center; Difference between lowest coefficients (center 17-Denmark, r=-0.15/-0.18 for BNSS/PANSS) and highest ones (center 12-Poland, r=-0.91/-0.82 for BNSS/PANSS) was not significant (z=2.78/2.05; p>0.05 Bonferroni corrected).
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References
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Merlotti, E., Mucci, A., Bucci, P., Nardi, A., Galderisi S., 2014. Italian version of the “Brief Negative Symptom Scale”. Journal of Psychopathology 20, 199-215
Wójciak, P., Górna, K., Domowicz, K., Jaracz, K., Gołębiewska, K., Michalak, M., Rybakowski, J., 2018. Polish version of the Brief Negative Symptom Scale (BNSS). Psychiatr. Pol. ONLINE FIRST 119, 1-9
Polat Nazlı, I., Ergül, C., Aydemir, Ö., Chandhoke, S., Üçok, A., Gönül, A.S., 2016. Validation of Turkish version of brief negative symptom scale. Int J Psychiatry Clin Pract. 20, 265-71
