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Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab

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Academic year: 2021

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Figure 1 Identification of a somatic EGFR mutation in colorectal adenocarcinoma via whole genome sequencing
Figure S3A), consistent with previous reports on G719X mutants in vitro and in lung cancer clinical trials [30-33] and with the failure of a previously identified patient with EGFR G724S mutant colorectal cancer to respond to gefitinib [29].
Figure 3 Dimerization disruption has effects on the transforming activity of G719S and G724S EGFR proteins

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