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Bridging the gap between drug discovery and synthetic biology : an alkaloid case study

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Bridging the gap between drug discovery and synthetic biology:

an alkaloid case study

Thomas Willems1, Maarten L. De Mol1, Jeltien Rombaut1, Aleksandar De Bruycker1, Sofie L. De Maeseneire1 and Wim K. Soetaert1

1 Centre for Industrial Biotechnology and Biocatalysis (InBio.be), Faculty of Bioscience Engineering, Ghent University, Belgium

E-mail: Maarten.DeMol@UGent.be

References

1 De Mol, Snoeck, et al. (2018). Biotechnology Advances, 36 (8): 2201-2218

2 Willems, De Mol, et al. (2020). Antibiotics (MDPI), 9 (6): 340

Address: Faculty of Bioscience Engineering, Coupure Links 653, Ghent (Belgium)

Microbial cell factories provide an interesting alternative to current extraction or chemical synthesis processes for the production of newly discovered compounds1. The choice of the microbial production host depends on both the identified molecule and the biochemical synthesis pathway. Here, we present an alkaloids case study from our recent review about all novel antimicrobial alkaloids discovered in marine fungi since 20152.

Biochemical hiatuses

Structure-activity studies required

Possible correlation antimicrobial activity and other bioactivities

Feel free to contact us for any information regarding this research or for collaborations!

Or check out our website: www.inbio.be

Collaboration?

Conclusions

Newly discovered alkaloids Biochemical production pathways

35 compounds

7 different alkaloid classes

Proposed biochemical origin

Antimicrobial effects

References Acknowledgements

This research was funded by the FWO in the framework of the PhD grant of Thomas Willems (Nr. 198258).

Introduction

Optimal microbial production

host?

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