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GABA and Glutamate Pathways Are Spatially and Developmentally Affected in the Brain of Mecp2-Deficient Mice

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Academic year: 2021

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Figure 1. Schematic representation of studied regions. The drawings are adapted from The Mouse Brain in Stereotaxic Coordinates atlas [38].
Figure 2. Neurochemical analysis of the GABA levels in A, the motor cortex; B, caudate-putamen; C, hippocampus; D, hypothalamus; E, substantia nigra pars reticulata; F, brainstem; G, cerebellum; H, spinal cord in P35 Mecp2- deficient (dashed/white bars) an
Table 2. Developmental changes (P55 vs P35) in glutamate concentrations in Mecp2-deficient or wild type mice.
Table 3. Expression changes of the key genes involved in the GABAergic and glutamatergic metabolism in the brain of pre- pre-symptomatic and pre-symptomatic in Mecp2-deficient versus wild type mice.
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