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Direct Action of Endothelin-1 on Podocytes Promotes Diabetic Glomerulosclerosis

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Academic year: 2021

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Figure 1. ETAR and ETBR podocyte-specific deletions do not alter glomerular structure. (A) RT-PCR analysis of Ednar and Ednbr mRNA expression in isolated podocytes from 10-week-old WT and Pod-ETRKO mice
Figure 2. Activation of the Ca 2+ pathway in podocytes stimulated by thrombin, ET-1, and sarafotoxin 6c
Figure 3. At basal state, b-catenin and NF-kB signaling pathways are decreased in glomeruli of Pod-ETRKO mice
Figure 4. In vitro, endothelin-1 activates b-catenin and NF-kB signaling pathways in glomeruli and its induction is decreased in Pod- Pod-ETRKO mice
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