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Evidence for IL-35 Expression in Diffuse Large B-Cell Lymphoma and Impact on the Patient's Prognosis

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Academic year: 2021

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FIGURE 1 | IL-35 is overexpressed in DLBCL compared to BL. (A–C) Gene expression values for EBI3 and p35 (IL12A) from B-cell lymphomas classified by molecular profiling as Burkitt lymphoma (mBL) or DLBCL (mDLBCL) were extracted from GSE4475 (A) and GSE4732
FIGURE 2 | 15k8D10 anti-IL-35/EBI3 mAb lacks specificity for EBI3. (A) The reactivity of 15k8D10 anti-IL-35/EBI3 mAb was tested by immunoblot against the cell lysate of OCI-Ly3 DLBCL cell line (30 µg total protein extract) and various recombinant proteins,
FIGURE 3 | Expression of IL-35 by tumor cells in DLBCL. (A) Specificity of the anti-p35 antibodies used for immunohistochemical studies
FIGURE 4 | Expression of IL-35 among the different molecular forms of DLBCL and correlation with overall survival in DLBCL patients from the GSE10846 dataset.
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