• Aucun résultat trouvé

Biodiversity as a barrier to glioma cell invasion.

N/A
N/A
Protected

Academic year: 2021

Partager "Biodiversity as a barrier to glioma cell invasion."

Copied!
6
0
0

Texte intégral

(1)

HAL Id: inserm-00733968

https://www.hal.inserm.fr/inserm-00733968

Submitted on 20 Sep 2012

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Biodiversity as a barrier to glioma cell invasion.

Laurent Selek, Franck Mauconduit, Marie-France Nissou, Guillaume Nugue,

Hana Lahrech, François Berger, Pascal Mossuz, Didier Wion

To cite this version:

Laurent Selek, Franck Mauconduit, Marie-France Nissou, Guillaume Nugue, Hana Lahrech, et al.. Biodiversity as a barrier to glioma cell invasion.. Medical Hypotheses, Elsevier, 2012, 78 (4), pp.459-61. �10.1016/j.mehy.2012.01.005�. �inserm-00733968�

(2)

12342567829ABC8BCBDC77267B93BEF23CB6FFB25C823B

B

C769B6F6

B

BB 7CBC3429

!B

BC726" 7C6B#2883

!B

B$2FFC6B

#E6

!

BB%CCBC76

!B

B 7C&328B167E67

!

BBBC8CFB388'

(

)BBB

C4B24267B*23

!)+B

B

12345672869AB9C2D5AED5F259825E69AE3649286529528A295482

;

C 9!"#9

$

528A298E66D69%2E9C2D5AE282E9825E6&9'AE23(9AD5259825E69AE3649286529

)*672869+'+94B549"!,-$9528A295482+99

(

12345672869AB9849.8A/2746AAF9

825E69AE3649286529"!,-$9528A295482+9

021D49A865D6A89 2 A552E3A8%8F94D6(A539%%25+4A85D6B/F528A2+B59

9

9

,D897C9-B A74E9 4529 27652729 4FF52EE29 48%9 26(49 BA57E9 AB9 5489 4825+9 8829 7489 A6(259 48259632E9FA7492E9545297264E64E92+9:(29E3524%96(5ADF(AD696(29548948%984E282EE9AB9 FA7492E9E949746A594DE29AB96(25432D69B4D52+989348692AEE6279A%25E6946E9A494E949 4552596A92AAF4984EA8+9)9484AF9429(3A6(2E9296(4696(29A4929%25E69AB9%BB25286462%9 6EED2E9 49 AD862534569 AB9 6(259 BD86A849 2BB289 A328E9 6(29 449 6A9 A49 48259 29 84EA8+9 22%8F96(2954896D7A5975A285A87286946(9(2625AF282ADE9293A3D46A8E9AD%92949724896A9 769482592984EA89928(488F929A%25E6+99

9

.9734923B

:D7A59 35AF52EEA89 52352E286E9 6(29A/2AD6A89AB9 6D7A592E946(9 6(25975A285A872869 ;<$"=+9 :(29%2496(469482592E92(4294E934869A594874984%8F94892AEE6279E98A69824+9 488F96(29 84%2%9 (46469 2EE9 (AE36429 (4E9 35A289 2BB2629 46(9 84E29 3486E9 48%9 4874E+9 )9 484AF9 46(9 2AEE627E9 4(2529 865A%D8F9 8A29 E322E9 489 24%9 6A9 A27E62829 A59 27686A89 69 489 29 (3A6(2E92%96(4696(29%22546297348646A89896(296D7A5975A285A872869AB92E9EED2%9B5A7949 %BB252869 A5F489 49 (48F29 7489 285A8728649 345472625E9 E7D6482ADE9 8D%8F9 39 3.$9 8D65286E9 6A8829 8264A58E9 27654/2D459 74657+9 :(2E29 (48F2E9 AD%9 89 6D589 46259 A49 6(29 AD5E29 AB9 6D7A59 35AF52EEA89 26(259 3AE629 A59 82F462+9 >A5%8F9 6(29 7348646A89 AB9 49 29 3A3D46A89 27(68F9 49 (F(259 35AB2546A89 54629 6(489 48259 2E9 48%9 %2%462%9 6A9 AD6/A732629 482592E9BA594442952EAD52E9(4E9228935A3AE2%94E9496(25432D69A36A89;-=+9?824E2948259

(3)

296(254394335A4(2E9894((928F82252%92E946E94E9482592E9352%46A5E9(429228935A3AE2%9 ;@#A=+99

9

%A/396828-99.D59(3A6(2EE9E96(4696(29A4929A%25E69AB9%BB25286462%9A5F48E9B4A5E96(29A49 84EA89AB9482592E+9:(E9(3A6(2EE9A5F8462E9B5A7934869E6D%2E9%27A8E65468F96(469A%25E69 489 469 4E9 49 455259 6A9 2AAF49 84EA89 ;!=+9 :(252BA529 8524E8F9 6(29 A%25E69 AB9 6(29 6EED29 4(25296D7A59%22A3E996(29A497348646A89AB92E9EED2%9B5A79A6(2596EED2E94AD%952352E286949 829 AB9 %2B28E29 4F48E69 6(29 E3524%9 AB9 84%8F9 48259 2E+9 >9 8A6429 3A869 E9 6(469 6(25432D69 734862%9 2E9 %A9 8A69645F269 482592E+9 :(29 4699 BDBB258FC9 4825929 84EA89 6(5ADF(9 6(29 8524E298929%25E69AB96(292AEE627+9:(E93A869E9564+9 AE69482596(25432E94529%2%462%9 6A9645F269482592E+9A422596(E91D2E69BA59E32B697F(69293454%A74949%54448+9)24DE29 AB9482592E9(2625AF2826948%934E6698A9A829645F262%96(25439489296(292E69A829BA59496(29 482592E9352E28698949F289346286+9.896(29A8654598524E8F96(29A%25E69AB96EED2E9%A2E98A69 645F26949E324948259293A3D46A89%5269D69546(2596(29482592AEE627+95A794972(48E69 3A869AB9249A8293AEE292734846A89489296(4694E9523A562%946(9348692AEE627E9;D=98524E8F9 6(292AEE6279%25E69D8BA579A425E96(2922E9AB952EAD52E+928296(E988%9AB94335A4(9AD%9 7696(292725F2829AB96(25432D6952EE6486948259293A3D46A8E+9896(2935A3AE2%97A%296(29A49 8524E29 89 A%25E69 %D29 6A9 7348646A89 AB9 (2625AF282ADE9 29 3A3D46A8E9 2722%E9 6(29 48259 29454693A62864+9:(E9896D58949769A6(96D7A59F5A46(948%96(29ED2EEBD9525D672869AB9 4825945486E+99 9 B %30B96BA/396828B3F4BD6B65CFC964B :A9DE654629(A494892962E62%96(29(3A6(2EE96(4698524E8F96EED2929A%25E69(47325E96D7A59 F5A46(942935A3AE296A9DE294954896D7A59273257286497A%2+9A74E9452954896D7A5E9BA594((9 8A9D546296(2543927E6E948%94(AE29F5A46(9E952E6562%96A96(29548+9)24DE29FA7492E9%A98A69 7264E64E929 ED549 E9 %5269 882%9 6A9 6(29 A49 A865A9 AB9 6(29 %E24E2+9 :(E9 D81D29 A6A329 35A%2E9 6(29 A33A56D869 6A9 82E6F4629 (A49 5489 6D7A59 2AEE6279 489 29 3256D52%9 4(289 29 A%25E698524E2E+9 A52A259734868F92E9896(295489E952462924E9%D296A96(29E929AB96(E9 A5F48+9>894%%6A8494%4864F29AB96(E97A%29E96(4696(29BAA49D39AB96(296D7A59E9472842989A99 4F2869 2EA884829 74F8F9 E F9 4((9 E9 429 6A9 A4929 48%9 724ED529 6(29 E929 AB9 6(29 6D7A59 DE8F91/1.:>949345474F8269A8654E694F286+9

:A9 %27A8E654629 (A49 6(29 (3A6(2EE9 AD%9 29 62E62%9 49 3A69 2732572869 44E9 325BA572%+9 89 6(29 EDFF2E62%9273257286494335A4(9@+<,-9(D7489FA7492E9;<,=942529734862%9896(295489AB98D%29 72948%96D7A59F5A46(944E94EE2EE2%9",9%4E9462599 9EF9<9>/1F+9:(2896(29A%25E69AB95489

(4)

6EED29 44E9 8524E2%9 9 86268F9 @+9 <,#92E9 EED2%9 B5A79 49 E3249 6329 AB9 A829 7455A49 2E9 27348%2%9 89 D6D529 8472%9 127625GE9 D6D529 ;<<=9 8E%29 48%9 45AD8%9 6(29 6D7A59 74EE+9B2E9 EED2%9 B5A79 1276259 D6D52E9 42529 (AAE29 6A9 F28254629 A%25E69 24DE29 F9 6(29 4529 (2625AF282ADE9 299 D6D52E9 9 B5A79 A829 7455A49 8D%8F9 B5A4E6E9 745A3(4F2E9 4%3A62E9 28%A6(249 2E9 72E28(749 E627+9 F9 1276259 2E9 E252629 6A882E9 48%9 A73A8286E9 AB9 6(29 276542D459 746579 ED(9 4E9 B5A82689 47889 48%9 A4F289 4((9 4EA9 345634629 6A9 6(29 A%25E69 AB9 6(29 75A285A87286H99F96(2945294296A9F282546294%%6A849A%25E694E96(29A864897D63A62869 72E28(749 E6279 2E9 4((9 (429 6(29 469 6A9 %BB252864629 86A9 7D6329 29 632E9 8D%8F9 AE62A4E6E9(A8%5A62E97A4E6E94%3A62E948%982D5A8E9;<$=948%H99F9A8297455A492E94529 846D549(428F2%989A96A9A6(98A57A7948%9(3A7975A285A87286E9;<"=949E6D46A894EA9 28AD86252%9896(29FA74975A285A87286+9:(569%4E94B6259A8297455A49E65A7492E9F54B68F9 E6(469 E9 E769 %4E9 4B6259 FA749 2E9 7348646A8F9 6D7A59 F5A46(9 489 29 24D462%9 9 9 EF+9 <F+9 :(E93A692732572869%27A8E65462E96(29B24E69AB962E68F96(295A29AB98524E8F929A%25E69A89 6D7A59 F5A46(9 46(9 6(E9 88%9 AB9 27325728649 7A%2+9 86252E68F9 9 74F8F9 E(A42%9 6(469 29 7348646A89AD%97696(2935AF52EEA89AB96(29%E24E29EF+9<91F9A73452%96A9A865A94874E9EF9 <+9>)F+9A4225946(ADF(94298A62%949E749F2825493AE6292BB269A896(29A2549ED549891276259 2E9652462%97ADE29EF+9<F96(292BB26944E9E646E6498A89EF8B4869E39I9,+,#F+9:(E9EDFF2E6E96(29 86252E69AB962E68F94%%6A84929776D52E+99 9 288823B )24DE29FA7492E9545297264E64E9296(2598B6546A8986A9548934528(749E949746A594DE29BA59 5489 6D7A59 6(25432D69 B4D52+9 >6(ADF(9 6(E9 35A328E69 AB9 84E282EE9 E9 489 8658E9 B246D529 AB9 48259 2E9 27658E9 2AAF49 B46A5E9 52462%9 6A9 6(29 6D7A59 75A285A872869 4529 4EA9 8A2%+9 >8A6(259B246D529AB9FA749E986546D7A5494825929(2625AF2826949746A59AE64296A96(29%2EF89AB9 645F262%96(25432E+9:(E9E96(29A8E21D2829AB96(29B4696(4696D7A592E92A29%D58F96(29AD5E29AB9 6(29 %E24E29 89 52E3A8E29 6A9 E226A89 352EED529 F2825462%9 A6(9 9 6(29 (48F8F9 6D7A59 75A/9 285A872869 48%9 9 54%A/9 A59 (27A6(25432E+9 A749 F5A4E9 24DE29 FA749 2E9 2E64E(9 3257EE29 2/6A/29 862546A8E9 46(9 82D5A8E9 75AF49 F49 2E9 48%9 4ED459 48%9 3253(2549 77D829 2E+9 2529 429 35A3AE29 6A9 BF(69 FA749 9 F2825468F9 89 6(29 6D7A59 285A872869 49 (F(259 229AB929A%25E692722%8F96(292AD6A845948%94%436293A628649AB9482592E+9:(293A69 2732572869352E2862%9(2529%27A8E65462E9(A496(29(3A6(2EE94892962E62%+9:(296(25432D692BB269 49%2328%9A896(29A25498D7259AB9734862%92E9D694EA9A896(29A7846A8E9AB96(29%BB252869 29 632E9 DE2%9 48%9 A89 6(29 6729 48%9 B521D289 AB9 29 7348646A8+9 J29 4529 444529 6(469 EA729 29 772E9 49 (429 4%25E29 2BB26E9 48%9 49 B464629 84EA89 9 35A7A68F9 6(29 6D7A59 2AEE6279 BD86A88F9 D69 A6(259 29 A7846A8E9 E(AD%9 A865D629 6A9 84EA89 52EE6482+9 :(DE9 A6(9 29

(5)

%25E69 48%9 29 A73AE6A89 4529 73A56486+9 89 5489 84EA89 5AD62E9 DE2%9 9 FA749 2E9 8D%29 728462%947A8E948%9AA%92EE2E+

9

2E94296A9AD396(2E297F546A596548E945296(252BA529FAA%9 48%%462E+9 >9 8A6429 86252E69 AB9 6(E9 6(25432D69 4335A4(9 4((9 489 29 242%9 4E9 489 B2AAF49 6(2543C9 ;"=9 E9 6(469 6(29 A49 8524E29 89 29 A%25E69 489 29 %A829 9 4D6AAFADE9 F54B68F+9 >9 3AEE29 %544489 E9 6(469 ED(9 A49 6(25439 AD%9 (429 49 762%9 86252E69 BA59 7264E64E9 6D7A5E+9 12625788F9 4((9 489 29 6(29 6(25432D649 7A529 2BB2869 29 BA57D46A89 49 521D529 489 27628E29 35AE32629 4A58+9 :(29 A868D46A89 AB9 6(E9 4A589 %2328%E9 6A9 6(29 4F452E9 AB9 6(29 BD8%8F9 35A2EE+9 (AD%9 6(469 35A2EE9 29 D8B4A5429 69 749 64829 E22549 245E9 2BA529 429 489 62E69 7A529 6(A5ADF(96(29(3A6(2EE96(46989FA74949F524698524E298929%25E69A425E9A496D7A59F5A46(9 54629 48%9 6A9 %26257829 4((9 29 776D52E9 4529 6(29 7AE69 2BB286+9 :(29 %24%9 846D529 AB9 FA749 6DE6B2E96(4696(E9(3A6(2EE94929543%962E62%+99 9 132F29B32B29676899>D6(A5E9523A5698A9A8B69AB986252E6+9 ;<=9 )+952E3948%9K+9D7725E9AD6A8459AAF9AB948259123456789AB78CAB9!39E$,,@F933+9 @-@/@@$+9 ;$=9 ?+ 25A9'+J+9L233259)+'+92%948%9++9 429482594E94892AD6A845948%92AAF49 35A2EE9DEF73C7E4932949E$,,#F933+9D$-/D"@+9 9;"=9 K+'+9L28649C+9 52FA59+9>725A%948%91++9>725A%9AAF496(25439BA59482539%2B88F9 6D7A5E9DE8F94892AEE62793454%F79EDFF2E6E98249A33A56D862E9BA598A2948259 652467286E912E46B749AB99E$,,!F933+9<@!/<#-+9 ;-=9 :++912EA28948%9M+9J48F9>98249A82369BA59482596(254339AD6/A73268F96(294FF52EEA59 E493273BB74F959E$,,!F93+9<D+9

;@=9 +9)282%2669)+9L5A49)+9LAA9?+9 4F54EE9 ++9)5D99A8291+9F47A8673F7EB92829 6(25439AB92732572864954896D7A5E9DE8F982D54935AF286A592E9DEF735949E$,,,F933+9 --A/-@,+9

;#=9 K++9>AA%9>+9)5A489C++948A9K+>+9)A4259+9?D9J+9N48F73F7EB9C2D549E62792E9 %E34927628E2965A3E79BA59346(AAF9894%D69548392%2829B5A79865454849FA74E9

2A97DEFB79E5797779679E$,,,F933+9<$!-#/<$!@<+9

99;A=99999 K+9C4847D549N+96A9N+9K4448A9K+9KD5A9D79 +9KAD829+9:ED%473F7EB9>866D7A592BB269AB9 F28264928F82252%972E28(749E62792E989495469FA7497A%29343713299E$,,-F9 33+9<<@@/<<#-+99 ;!=9 :+>+9K2882%9+9C42279K+ +9A429'+ +9K8A3E91+9:748948%9L+92(9)A%25E694E949 4552596A92AAF4984EA89DEF239879E$,,$F933+9#"#/#"!99 ;D=9 1+9:7489C(29654%2ABBE982D6546948%9A77D869E65D6D523949E6A(4E696(2A59AB9 52EAD529A73266A8984EA8948%9A77D8694EE2792A97DEFB79E579777939 E$,,-F933+9<,!@-/<,!#<+9 ;<,=9 C+9L46269+N+9?D9 ++9>6B9?+9.259+ +9O426629+9)25F2573F7EB98BD2829AB9A7F289 628EA89A891<""93(28A632989(D7489FA74929D6D52E9E493273FF9!959E$,,AF933+9$!#/ $D,+9 ;<<=9 :+ +91276259:+1+9>28948%9?++9?466(49A8%6A8E9A865A8F96(2935AB2546A89AB9 (427A3A269E62792E98965A9 73BB7!6AB969E<DAAF933+9""@/"--+99 ;<$=9 M+'+9?D9N+9M(DF2948%9.++9O2491D299:54BB88F948%9%BB2528646A89AB972E28(749E6279 2E9 73BB7"A93#9349E$,,DF933+9D!-/DD<+9

(6)

;<"=9 >+O+9D64569 +9477AD%9L+912A94549M+948A948%9O+9L54A5489A4/ 8FP1D2E282944829AB9(2746A3A269E62792E9E952462%96A93(EAAF49F54%2869AB9 A7F2898$%7&3#EFAB9(5933+9!-A/!@<+9 +9 9 99 9 2E76B6E648B B 2E-B.CE2EB96B62269B32BD2342567829AB3B937B/73E768823B B 9BAA49D39AB96D7A59F5A46(9469%49",948%9#,94B6259FA749297348646A89896(294E2829E>)F9 A59352E28299E1F9AB912762592E+9A591276259297348646A89@+9<,#92E942529734862%9",9%4E9 4B6259FA7492E97348646A8+9EFBK4348/ 2259ED549D52E9E(A494966298524E29896(29ED549 AB9 729 5228F9 49 1276259 29 7348646A89 48%9 45AD8%9 6(29 6D7A59 74EE9 EF52289 82F9 A73452%9 6A9 A865A9729734862%946(9FA7492E9A89ED2982F9E39I9,+,#9AF95488962E6F+99 CAB(3 CAB43

,

1

#3B6:967 6FF8 2/FC9C923

1



6:967 6FF8 2/FC9C923 CAB(3 CAB43

;

9

Références

Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to