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Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy

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Academic year: 2021

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Figure 3. Effect of DPT-C9h on caspase-9 activation, mitochondrial membrane depolarization, cytochrome c release and cell cycle.
Figure 5. In vivo antibody responses and toxicity induced by DPT-C9h. A) Serum antibodies taken from nude mice treated for different periods of time were detected by ELISA at two different concentrations of DPT-C9h peptide (10 and 50 mM)
Figure 6. In vivo therapeutic efficacy of DPT-C9 and DPT-C9h. A) The peptide DPT-C9 was administrated IP at 5 mg/kg once daily, 5 days a week for 4 weeks in the K-Ras LA1 adenocarcinoma mouse model, showing a significant decrease in lung tumour burden comp

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