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Pilot trial of adjuvant paclitaxel plus androgen deprivation for patients with high-risk prostate cancer after radical prostatectomy: results on toxicity, side effects and quality-of-life.

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HAL Id: inserm-00460481

https://www.hal.inserm.fr/inserm-00460481

Submitted on 1 Jun 2010

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Pilot trial of adjuvant paclitaxel plus androgen deprivation for patients with high-risk prostate cancer

after radical prostatectomy: results on toxicity, side effects and quality-of-life.

Guillaume Ploussard, Bernard Paule, Laurent Salomon, Yves Allory, Stéphane Terry, Dimitri Vordos, Andras Hoznek, Francis Vacherot, Claude-Clément

Abbou, Stéphane Culine, et al.

To cite this version:

Guillaume Ploussard, Bernard Paule, Laurent Salomon, Yves Allory, Stéphane Terry, et al.. Pi- lot trial of adjuvant paclitaxel plus androgen deprivation for patients with high-risk prostate cancer after radical prostatectomy: results on toxicity, side effects and quality-of-life.. Prostate Cancer and Prostatic Diseases, Nature Publishing Group, 2010, 13 (1), pp.97-101. �10.1038/pcan.2009.51�.

�inserm-00460481�

(2)

Grade I-II (%) Grade III (%)

Fatigue 8 (34.8) 0

Nail changes 6 (26.1) 0

Anemia 15 (65.2) 0

Thrombocytemia 1 (4.3) 0

Neutropenia 4 (17.4) 0

Febrile neutropenia 0 1 (4.3)

Diarrhea 1 (4.3) 0

Nausea 2 (8.7) 0

Epistaxis 1 (4.3) 0

Sensory neuropathy 4 (17.4) 0 Left ventricular systolic

dysfunction

0 1 (4.3)

Non febrile urinary infection

2 (8.7) 0

Hand erythema 2 (8.7) 0

Thromboembolism 0 1 (4.3)

Rhinpharyngitis 2 (8.7) 0

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