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Chromosomal profiles of gene expression in Huntington's disease.

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Academic year: 2021

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Fig. 1   Histone acetylation is generally linked to transcriptional activation. Histone acetyltransferases (HATs)  acetylate lysine residues at the N-terminals of histone proteins, resulting in a loosely packed chromatin structure  in which DNA promoter re
Fig. 2  Case loadings for blood sample datasets. HD patients (black bars, cases HDI-12), controls (white bars,  cases NI-14) and pre-symptomatic patients (black bars, cases PI-5)
Fig. 3   Pattern of chromosomal expression extracted by Chromowave for blood sample datasets: x-axis  represents the genomic distance along each of the chromosomes; y-axis represents the gene expression  contribution (intensity and direction, log2 scale)
Fig. 4  Case loadings for caudate sample datasets (controls = white, HD patients = black, with numbers above  plots indicating Vonsattel scale of disease pathology)
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