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Cell-type specific determinants of NRAMP1 expression in professional phagocytes

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Academic year: 2021

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Figure 1. Phylogenetic distribution of Nramp in eukaryotes (Opisthokonta). Multicellular  organisms possess archetype Nramp whereas Saccharomyces cerevisiae retained only  prototype Nramp
Figure 2. Control of SLC11A1 gene expression during myelopoiesis. (A) Simplified  hematopoietic scheme including mature cell types and highlighting the committed progenitors  of the myeloid pathway: common myeloid progenitor (CMP), megakaryo-erythrocytic
Figure 3. Transcriptional activity at SLC11A1 locus 2q35. (A) University of California  Santa Cruz (UCSC) genome browser [149] visualization of chromosome 2 and blow-up at  q35 showing coordinates, scale (20 kb) and few basic sequence elements: common repe
Figure 4. Nucleosomal remodeling at SLC11A1 locus in mature CD14 +  monocytes. (A)  2q35 coordinates, CpG islands, DNAse I hypersensitivity clusters and RefSeq genes as in  Figure 3; red boxes indicate the 11 DNAse I hypersensitivity clusters highly repres
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