Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas.

Texte intégral

(1)Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas. Virginie Granci, Frédéric Bibeau, Andrew Krama, Florence Boissière-Michot, Simon Thézénas, Agnès Thirion, Céline Gongora, Pierre Martineau, Maguy del Rio, Marc Ychou. To cite this version: Virginie Granci, Frédéric Bibeau, Andrew Krama, Florence Boissière-Michot, Simon Thézénas, et al.. Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas.. European Journal of Cancer, Elsevier, 2008, 44 (15), pp.2312-8. �10.1016/j.ejca.2008.06.042�. �inserm00318854�. HAL Id: inserm-00318854 https://www.hal.inserm.fr/inserm-00318854 Submitted on 5 Sep 2008. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) Prognostic significance of TRAIL-R1 and TRAIL-R3 expression in metastatic colorectal carcinomas.. Virginie Granci1*, Frédéric Bibeau2*, Andrew Kramar3, Florence Boissière-Michot2, Simon Thézénas 3, Agnès Thirion4, Céline Gongora1, Pierre Martineau1, Maguy Del Rio1 and Marc Ychou4.. 1. IRCM, Institut de Recherche en Cancérologie de Montpellier; INSERM, U896;. Université Montpellier1; CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, 2. 3. France ; Service d’Anatomie Pathologique, Unité de Biostatistique,. 4. and Service. d’Oncologie Digestive, Centre Régional de Lutte contre le Cancer Val d’Aurelle-Paul Lamarque, Montpellier, F-34298, France. * These authors contributed equally to the work. To whom correspondence should be addressed: Dr. Maguy Del Rio IRCM, INSERM, U896 CRLC Val d' Aurelle-Paul Lamarque 208 rue des Apothicaires 34298 Montpellier Cedex 5 France Tel: +33-467-613-745. Fax: +33-467-613-787. e-mail: mdelrio@valdorel.fnclcc.fr.

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(94) Figure 1 Medium. High. . . Low. Trail-R1. Trail-R2. . Trail-R3. . TrailR4.

(95) Figure 2. Low 100 % 90 % 80 % 70 % 60 % 50 % 40 % 30 % 20 % 10 % 0 %. pCR. H. TRAIL-R1. pCR. Medium. H. TRAIL-R2. High. pCR. H. TRAIL-R3. pCR. H. TRAIL-R4.

(96) Figure 3. p = 0.0034 Poor Intermediate/good rrr.

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