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Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry
SCHELLONG, Sebastian M, et al.
Abstract
Isolated distal deep vein thrombosis (IDDVT) represents up to half of all lower limb DVT. This study investigated treatment patterns and outcomes in 2,145 patients with IDDVT in comparison with those with proximal DVT (PDVT; n = 3,846) and pulmonary embolism (PE; n = 4,097) enrolled in the GARFIELD-VTE registry. IDDVT patients were more likely to have recently undergone surgery (14.6%) or experienced leg trauma (13.2%) than PDVT patients (11.0 and 8.7%, respectively) and PE patients (12.7 and 4.5%, respectively). Compared with IDDVT, patients with PDVT or PE were more likely to have active cancer (7.2% vs. 9.9% and 10.3%). However, influence of provoking factors on risk of recurrence in IDDVT remains controversial. Nearly all patients (IDDVT, PDVT, and PE) were given anticoagulant therapy. In IDDVT, PDVT, and PE groups the proportion of patients receiving anticoagulant therapy was 61.4, 73.9, and 81.1% at 6 months and 45.8, 54.7, and 61.9% at 12 months. Over 12 months, the incidence of all-cause mortality, cancer, and recurrence was significantly lower in IDDVT patients than PDVT patients (hazard ratio [HR], 0.61 [...]
SCHELLONG, Sebastian M, et al . Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry. Thrombosis and Haemostasis , 2019, vol. 19, no. 10, p. 1675-1685
DOI : 10.1055/s-0039-1693461 PMID : 31370075
Available at:
http://archive-ouverte.unige.ch/unige:133081
Disclaimer: layout of this document may differ from the published version.
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Supplementary Table S1 Regional characteristics at baseline (among 28 participating countries)
IDDVT (N¼2,145)
PDVT (N¼3,846)
PE
(N¼4,097)
Total (N¼10,088)
Europe 1,198 (55.9) 2,095 (54.5) 2,374 (57.9) 5,667 (56.2)
Belgium 21 (1.0) 81 (2.1) 213 (5.2) 315 (3.1)
Czech Republic 191 (8.9) 216 (5.6) 290 (7.1) 697 (6.9)
Denmark 42 (2.0) 42 (1.1) 130 (3.2) 214 (2.1)
France 147 (6.9) 171 (4.4) 266 (6.5) 584 (5.8)
Germany 113 (5.3) 189 (4.9) 217 (5.3) 519 (5.1)
Italy 60 (2.8) 250 (6.5) 275 (6.7) 585 (5.8)
Netherlands 27 (1.3) 111 (2.9) 59 (1.4) 197 (2.0)
Russia 163 (7.6) 355 (9.2) 152 (3.7) 670 (6.6)
Spain 21 (1.0) 105 (2.7) 177 (4.3) 303 (3.0)
Switzerland 41 (1.9) 24 (0.6) 94 (2.3) 159 (1.6)
Turkey 204 (9.5) 201 (5.2) 190 (4.6) 595 (5.9)
UK 168 (7.8) 350 (9.1) 311 (7.6) 829 (8.2)
Asia 361 (16.8) 679 (17.7) 685 (16.7) 1,725 (17.1)
China 89 (4.1) 177 (4.6) 145 (3.5) 411 (4.1)
Hong Kong 22 (1.0) 32 (0.8) 37 (0.9) 91 (0.9)
Japan 56 (2.6) 32 (0.8) 49 (1.2) 137 (1.4)
Malaysia 53 (2.5) 101 (2.6) 69 (1.7) 223 (2.2)
South Korea 50 (2.3) 74 (1.9) 198 (4.8) 322 (3.2)
Taiwan 54 (2.5) 72 (1.9) 92 (2.2) 218 (2.2)
Thailand 37 (1.7) 191 (5.0) 95 (2.3) 323 (3.2)
North America/Australia 209 (9.7) 374 (9.7) 756 (18.5) 1,339 (13.3)
Australia 100 (4.7) 51 (1.3) 186 (4.5) 337 (3.3)
Canada 30 (1.4) 204 (5.3) 287 (7.0) 521 (5.2)
USA 79 (3.7) 119 (3.1) 283 (6.9) 481 (4.8)
Latin America 91 (4.2) 160 (4.2) 104 (2.5) 355 (3.5)
Argentina 50 (2.3) 69 (1.8) 73 (1.8) 192 (1.9)
Brazil 24 (1.1) 78 (2.0) 10 (0.2) 112 (1.1)
Mexico 17 (0.8) 13 (0.3) 21 (0.5) 51 (0.5)
Other 286 (13.3) 538 (14.0) 178 (4.3) 1,002 (9.9)
Egypt 246 (11.5) 296 (7.7) 43 (1.0) 585 (5.8)
South Africa 40 (1.9) 242 (6.3) 128 (3.1) 410 (4.1)
United Arab Emirates — — 7 (0.2) 7 (0.1)
Abbreviations: IDDVT, isolated distal deep vein thrombosis; PDVT, proximal deep vein thrombosis; PE, pulmonary embolism.
Thrombosis and Haemostasis
Isolated Distal Deep Vein Thrombosis Schellong et al.
Supplementary Fig. S1Ratio of isolated distal deep vein thrombosis (IDDVT):proximal DVT (PDVT): global scope and per individual country.
Thrombosis and Haemostasis
Isolated Distal Deep Vein Thrombosis Schellong et al.
