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Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model

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Academic year: 2021

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Figure 1 | Spatial learning and memory and CA1 LTP deficits in Pyk2 mutant mice. (a) In the spontaneous alternation test, Pyk2 þ /þ , Pyk2 þ /  and Pyk2  / 3-month-old mice were placed for 10 min in a Y-maze with one arm closed (upper left panel)
Figure 2 | Hippocampal proteins phosphorylation and levels in Pyk2-deficient mice. (a) Immunoblotting analysis of Pyk2, the related tyrosine kinase FAK, the active autophosphorylated form of Src-family kinases (pY-SFK, pTyr-420 in Fyn), Fyn and tubulin as a
Figure 3 | Pyk2 localization and dendritic spine density and morphology in Pyk2-deficient mice
Figure 4 | Pyk2 ablation in CA1 from adult mice induces spatial learning deficits and spine alterations
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