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Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development

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Academic year: 2021

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Figure 1. sGFP::MEI-2 dynamics during C. elegans development. (A) Spinning disk confocal micrographs of adult worm expressing sGFP::MEI-2 (in green) and mCherry::HIS-11 (in red) exposed to control (i) or mei-1(RNAi) (ii)
Figure 3. Phosphorylation of the N-terminal disordered region of MEI-1 inhibits the stimulatory effect of MTs on Katanin ATPase activity.
Figure 4. Site-specific MEI-1 phosphorylation at S92 increases MEI-1 affinity for MEL-26
Figure 5. The nonphosphorylatable MEI-1 S92A version is toxic in vivo in the absence of endogenous MEI-1
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