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Genetic predisposition and environmental factors associated with the development of atopic dermatitis in infancy: a prospective birth cohort study Journal : European Journal of Pediatrics Caroline Gallay

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Genetic predisposition and environmental factors associated with the development of atopic dermatitis in infancy: a prospective birth cohort study

Journal : European Journal of Pediatrics

Caroline Gallay1,4, Patrick Meylan1,4, Sophie Mermoud1, Alexandre Johannsen1, Caroline Lang1, Carlo Rivolta2,3 and Stéphanie Christen-Zaech1

1Pediatric Dermatology Unit, Departments of Pediatrics and Dermatology, Lausanne University Hospital, Switzerland

2Department of Computational Biology, Unit of Medical Genetics, University of Lausanne, Switzerland

3Department of Genetics and Genome Biology, University of Leicester, United Kingdom

4these authors contributed equally to this work

Corresponding author

Dr. Stephanie Christen-Zaech, PD, MSCI Hôpital de Beaumont

Avenue de Beaumont 29 CHUV – 1011 Lausanne Tel. + 41 79 556 03 05 Fax: + 41 21 314 03 92 stephanie.christen@chuv.ch

Supplementary Material : 5 Questionnaires

(2)

Anamnestic questionnaire Number of the clinical trial : CHILD

1. What is the sex of the child? !! M

!! F 2. Difference from expected weight (g)? !! ≤-500

!! -499 to -200

!! -199 to 199

!! 200 to 499

!! ≥500

3. How many weeks was the child born? !! 37-38

!! 39-40

!! >41

4. In what season was the child born? !! Spring (March-May)

!! Summer (June-August)

!! Fall (September-November)

!! Winter (December-February) MOTHER

5. Mom's age at the time of birth? !! ≤24

!! 25-29

!! 30-34

!! ≥35 6. What kind of delivery did the mother have? !! normal way

!! caesarean 7. Did she have respiratory infections during her pregnancy? !! Yes

!! No

If yes, which? ………..

8. Did she take antibiotics during her pregnancy? !! Yes

!! No 9. Was she vaccinated during pregnancy? !! Yes

!! No

If yes, which? ………..

PEDIGREE

1. Atopic dermatitis 2. Allergic asthma 3. Allergic rhinitis

(3)

Lifestyle questionnaire Visit 1

Number of the clinical trial:

_________________

Date of birth of the parents:

Mother ____________ Father ______________

Profession of the parents:

Mother ____________ Father ________________

Postal code: ________________

Please check what is appropriate.

TO BE COMPLETED BY PARENTS

1. Where do you leave? In town

In the countryside

On a farm

2. Which level of education did the mother reach?

Basic education

High school

University of applied sciences

University

3. Which level of education did the father reach?

Basic education

Gymnase

High school

University

4. How many kids do you have? 1

2

3

4 or more

5. What is the yearly income of your household? (in CHF)

< 90 000

90 000-120 000

>120 000

6. Did you move less than a year ago in a Yes

No

(4)

freshly built/renovated home?

7. Did you renovate your home less than a year ago ?

Yes

No

8. Do you use the microwave more than 5 times per week?

Yes

No

9. Which material is covering the floor of your home? (except in the kitchen and the bathroom)

Only wood

Only floor tile

Only carpet

Only carpeting

Carpet covering the entire floor where your kid is sleeping

Other: …………..

10. In which frequency are you cleaning your home?

1x/week

1x/ 2 weeks

1x/ month

11. Is the level of humidity high in your home? (mold)

Yes

No

12. Do you have cockroaches at home? Yes

No

13. Do you have farm animals with furs or feathers?

Yes

No

If yes, which ones? ...

14. Do you have domestics animals with furs or feathers?

Yes

No

If yes, which ones? ...

15. Is there a smoker in your home? Yes

No

If yes, the person smokes:

At an open window

With the windows closed

TO BE COMPLETED BY THE MOTHER

16. Did you smoke during your pregnancy? Yes

No

17. Did you drink alcohol during your pregnancy?

Yes

No

18. Did you take fish oil 4g / day throughout your pregnancy?

Yes

No

19. Is there some home renovation inside your house during your pregnancy?

Yes

No

(5)

Life style questionnaire Visit 6

Number of the clinical trial:

_________________

Please check what is appropriate.

TO BE COMPLETED BY PARENTS

1. Do you use the microwave more than 5 times per week?

Yes

No

2. How frequently do you clean your home?

1x/week

1x/ 2 weeks

1x/ month

3. Is the level of humidity high in your home? (mold)

Yes

No

4. Do you have cockroaches at home? Yes

No

5. Do you have farm animals with furs or feathers?

Yes

No

If yes, which ones? ...

6. Do you have pets with furs or feathers? Yes

No

If yes, which ones? ...

7. Is there a smoker in your home? Yes

No

If yes, the person smokes:

At an open window

With the windows closed

8. How long has your child been hospitalized after birth?

Less than 10 days

Between 10 and 20 days

More than 20 days

9. Did your child have invasive procedures (central venous catheter, peripheral venous catheter, parenteral nutrition, ventilation, intubation, nasogastric tube, surgery) during his first weeks of life?

Yes

No

If yes, which ones? ...

10. Did your child have a positive allergy test with cats?

Yes

No

11. Did your child have a positive pollen allergy test?

Yes

No

12. Did your child have a positive allergy test with mites?

Yes

No

13. Did your child have a allergic rhinitis? No

Yes, diagnosed by a doctor

Yes, undiagnosed by a doctor

14. Did your child have a allergic asthma? No

Yes, diagnosed by a doctor

Yes, undiagnosed by a doctor

15. Did your child have a cold that lasted No

Yes 1x

(6)

more than 3 days? Yes 2x

Yes 3x or more

16. Did your child have a diarrhea that lasted more than 3 days?

No

Yes 1x

Yes 2x

Yes 3x or more

17. Did your child have a middle ear infection?

No

Yes 1x

Yes 2x

Yes 3x or more

18. Did your child have a pneumonia? No

Yes 1x

Yes 2x

Yes 3x or more

19. Did your child have chickenpox? Yes

No

20. How many times did you bring your child to the paediatrician due to an infection?

0

1x

2x

3x or more

21. Have you ever given antibiotics to your child?

Yes

No

If yes:

Local

Per os

22. Have you ever given antifungals to your child?

Yes

No

If yes:

Local

Per os

23. How many times has your child received the Di Te Pol Per vaccine?

0

1x

2x

3x

4x

24. How many times has your child received the Hib vaccine?

0

1x

2x

3x

4x

Life style questionnaire

(7)

Visit 9 and 11

Number of the clinical trial:

_________________

Please check what is appropriate.

TO BE COMPLETED BY PARENTS

1. Do you use the microwave more than 5 times per week?

Yes

No

2. How frequently are you cleaning your home?

1x/week

1x/ 2 weeks

1x/ month

3. Is the level of humidity high in your home?

(presence of mold)

Yes

No

4. Do you have cockroaches at home? Yes

No

5. Do you have farm animals with furs or feathers?

Yes

No

If yes, which ones? ...

6. Do you have pets with furs or feathers? Yes

No

If yes, which ones? ...

7. Is there a smoker in your home? Yes

No

If yes, the person smokes:

At an open window

With the windows closed

8. Did your child have a positive allergy test with cats?

Yes

No

9. Did your child have a positive pollen allergy test?

Yes

No

10. Did your child have a positive allergy test with mites?

Yes

No

11. Did your child have allergic rhinitis? No

Yes, diagnosed by a doctor

Yes, undiagnosed by a doctor

12. Did your child have allergic asthma? No

Yes, diagnosed by a doctor

Yes, undiagnosed by a doctor

13. Did your child have a cold that lasted more than 3 days?

No

Yes 1x

Yes 2x

Yes 3x or more

14. Did your child have a diarrhea that lasted more than 3 days?

No

Yes 1x

Yes 2x

Yes 3x or more

15. Did your child have middle ear infection? No

Yes 1x

Yes 2x

Yes 3x or more

16. Did your child have a pneumonia? No

Yes 1x

(8)

Yes 2x

Yes 3x or more

17. Did your child have chickenpox? Yes

No

18. How many times did you bring your child to the paediatrician due to an infection?

0

1x

2x

3x or more

19. Have you ever given antibiotics to your child?

Yes

No

If yes:

Local

Per os

20. Have you ever given antifungals to your child?

Yes

No

If yes:

Local

Per os

21. How many times has your child received the Di Te Pol Per vaccine?

0

1x

2x

3x

4x

22. How many times has your child received the Hib vaccine?

0

1x

2x

3x

4x

23. How many times has your child received the ROR vaccine?

0

1x

2x

Questionnaire on child nutrition Number of the clinical trial:

1. Do you breastfeed or did No

Yes, exclusively

(9)

you breastfeed your child?

If not or not exclusively, what extra milk did you give him?

Yes, but not exclusively

Hydrolyzed milk (ex: Alfaré, Damira, Pregomin)

Cow's milk

Milk with soy

Hypoallergenic milk ("HA" type)

Other: ...

2. How long did you breastfeed your child?

< 3 months

≥ 3 months

≥ 4 months

≥ 6 months

3. At what age did you introduce solid food to your child?

< 4 months (as currently recommended)

4-6 months

6-8 months

9 months

10 months or more

4. When did the child eat the following foods for the first time ?

- Egg - Fish - Cow milk - Kiwi - Sea food - Corn

- Nuts and hazelnuts - Peanuts

- Celery

<6months

<6months

<6months

<6months

<6months

<6months

<6months

<6months

<6months

6-12

6-12

6-12

6-12

6-12

6-12

6-12

6-12

6-12

>12months

>12months

>12months

>12months

>12months

>12months

>12months

>12months

>12months

5. Did your child have positive allergic tests for any of the following foods?

- Egg - Cow milk - Peanuts - Hazelnut - Corn

Yes

Yes

Yes

Yes

Yes

No

No

No

No

No

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