• Aucun résultat trouvé

In vivo myofibre architecture in the systemic right ventricle

N/A
N/A
Protected

Academic year: 2021

Partager "In vivo myofibre architecture in the systemic right ventricle"

Copied!
1
0
0

Texte intégral

(1)

41. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after imple-mentation of a preparticipation screening program. JAMA 2006;296: 1593 – 1601.

42. Noheria A, Teodorescu C, Uy-Evanado A, Reinier K, Mariani R, Gunson K, Jui J, Chugh SS. Distinctive profile of sudden cardiac arrest in middle-aged vs. older adults: a community-based study. Int J Cardiol 2013 May 16, doi:pii: S0167-5273(13)00890-5. 10.1016/j.ijcard.2013.04.207. Published online ahead of print.

43. Drezner JA. Detect, manage, inform: a paradigm shift in the care of athletes with cardiac disorders? Br J Sports Med 2013;47:4 – 5.

44. Drezner JA, Levine BD, Vetter VL. Reframing the debate: screening athletes to prevent sudden cardiac death. Heart Rhythm 2013;10:454 – 455.

45. Chugh SS. Early identification of risk factors for sudden cardiac death. Nat Rev Cardiol 2010;7:318 – 326.

46. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 2000;343: 1355 – 1361.

47. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med 1984;311:874 – 877.

48. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003;42:1959–1963.

CARDIOVASCULAR FLASHLIGHT

. . . . doi:10.1093/eurheartj/eht442

Online publish-ahead-of-print 18 October 2013

In vivo myofibre architecture in the systemic right ventricle

Jack Harmer1†*, Kuberan Pushparajah1†, Nicolas Toussaint1, Christian T. Stoeck2, Rachel Chan3,

David Atkinson3, Reza Razavi1, and Sebastian Kozerke1,2

1

Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, UK;2

Institute for Biomedical Engineering, University and ETH Zurich, Switzerland; and3

Centre for Medical Imaging, University College London, London, UK

*Corresponding author. Division of Imaging Sciences, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas’ Hospital, London SE1 7EH, UK. Tel:+44 207-188 5441; Fax: +44 207 188 5442, Email :jack.harmer@kcl.ac.uk

Equal Contributors.

Heart failure in the systemic right ventricle (RV) is a common pathway in end-stage disease in patients affected with congenital heart disease. Using state-of-the-art magnetic resonance (MR) diffusion acquisition schemes, we present the first in vivo dif-fusion tensor imaging (DTI) data of the beating heart acquired in an adult with a systemic RV fol-lowing an atrial switch procedure for transposition of the great arteries. Magnetic resonance-based DTI acquisitions provide information about the predominant direction of structures within each voxel of the acquired image. These aggregates, which are often interpreted as fibres, appear as co-herent orientational structures throughout the myocardium. Knowledge of cardiac myocyte archi-tecture has the potential to transform our under-standing of cardiac function and the mechanisms behind heart failure. Until recently, direct visualiza-tion of myofibre architecture has been limited to ex vivo specimens due to cardiac motion. However, recent advances in MRI now allow for robust DTI of the beating heart and can provide in vivo knowl-edge of myofibre architecture. In the data pre-sented here, diffusion tensors are shown across multiple slices and are colour coded to indicate helix angle (Panels A – E). Full 3D reconstructions

across the volume of the heart are also shown. Helix angle distributions indicate a predominance of circumferential fibres across the entire healthy LV and in the anterior and inferior segments of the systemic RV. However, in the lateral wall of the systemic RV, helix angles are skewed towards negative values. This indicates a predominance of longitudinal and oblique fibres with a clockwise helix orien-tation and is likely brought about to adaporien-tation of the RV to systemic pressure and load.

This work was supported by the UK EPSRC (EP/I018700/1), Adult Congenital Heart Disease Service Guy’s and St Thomas’ NHS foun-dation Trust, and the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Founfoun-dation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

Published on behalf of the European Society of Cardiology. All rights reserved.&The Author 2013. For permissions please email: journals.permissions@oup.com

E. Marijon et al.

Références

Documents relatifs

Reconstruction of a longitudinal image of the radius obtained, (a) if the anisotropic model for the wave-speed in cortical bone (equation (1)) and the optimal values (table 2)

Prof Dr Francis Masin, Université Libre de Bruxelles (co-promoter) Prof Dr Thomas Erneux, Université Libre de Bruxelles..

The local cost function in this work is calculated from two compo- nents: multiscale gradient magnitudes and gradient direction and (b) our single X-ray image–based 2D/3D

To cope with intensity fluctuations arising due to motion, our strategy was to acquire multiple diffusion weighted (DW) images at different time points during the diastole in

The following details are given: (1) Super-mini underwater robot system design by developing a much more powerful and intelligent control platform for underwater robot;

The purpose of this chapter was to further study in vivo cardiac fiber architectures of the human heart by investigating a second method addressing motion problem -

la coupe de Saint-Blin-Sémilly a permis de mettre en évidence l’évolution des associations de faciès et des environne- ments de dépôt latéralement à des séries condensées

‫اﻟدرﺟﺔ اﻟﺛﺎﻟﺛﺔ إﺧطﺎر ﻣﻔﺗﺷﯾﺔ اﻟﻌﻣل أو اﻟﺟﻬﺔ اﻟﻘﺿﺎﺋﯾﺔ اﻟﻣﺧﺗﺻﺔ ﻓﻲ أﺟل ‪ 15‬ﯾوﻣﺎ‪ ".....‬ﻓﻌﻠﻰ‬ ‫اﻟرﻏم ﻣن أن اﻟطﺑﯾﻌﺔ اﻹدارﯾﺔ ﻟﻬذﻩ اﻟوﻛﺎﻟﺔ ﺗﺳﺗﻠزم