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The Q-loop Disengages from the First Intracellular Loop during the Catalytic Cycle of the Multidrug ABC Transporter BmrA

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Academic year: 2021

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FIGURE 1. Topology of BmrA and sequence alignments. A, predicted topology of BmrA and location of the first intracellular loop (ICL1) and the Q-loop within the NBD
TABLE ONE
FIGURE 4. ATP/Mg binding triggers a conformational change moving the cysteine residue in the NBD away from the cysteine residue in the ICL1
FIGURE 6.Putative scheme to explain the disulfide bond formation, or prevention, in the BmrA double mutants

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