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Rapid diagnostic protocol for patients with chest pain.

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HAL Id: inserm-00679724

https://www.hal.inserm.fr/inserm-00679724

Submitted on 16 Mar 2012

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Rapid diagnostic protocol for patients with chest pain.

Alexis Descatha, Sarah Derian, Charles Groizard

To cite this version:

Alexis Descatha, Sarah Derian, Charles Groizard. Rapid diagnostic protocol for patients with chest pain.. Lancet, Elsevier, 2011, 378 (9789), 398; author reply 398-9. �10.1016/S0140-6736(11)61205-1�. �inserm-00679724�

(2)

Missing data and health inequalities?

Reply to “A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT)”

DESCATHA Alexis 1,2,3, DERIAN Sarah 3, GROIZARD Charles 3

1. Inserm U1018, Centre for research in Epidemiology and Population Health,

Epidemiology of occupational and social determinants of health, Villejuif, France ;

2. Université de Versailles St-Quentin, UMRS 1018, France ;

3. AP-HP, Poincaré University Hospital, Occupational health department/ EMS92

(SAMU92), Garches, France.

Corresponding author. Alexis Descatha MD PhD, Inserm U1018, UVSQ, Unité de

pathologie professionnelle SAMU92, CHU Poincaré, 104 bd Poincaré, 92380 Garches,

France

(i) Declaration of interest: the author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.

(ii) No copyright constraints.

(iii) No prior or duplicate publication or submission had been made elsewhere

(iv) Author: contribution: DESCATHA Alexis, DERIAN Sarah, GROIZARD are responsible for the content and writing of the paper.

Tel: +33 (1) 47 10 77 54; Fax: +33 (1) 47 10 77 68; email: alexis.descatha@rpc.aphp.fr

Funding : none, ICMJE complete, no conflict of interest

(3)

Sir,

We read with a particular interest the paper by Than and al. about accelerated diagnostic

protocol to assess patients with chest symptoms (1). Based on the Thrombolysis in

Myocardial Infarction (TIMI) score, electrocardiogram, and point-of-care biomarker panel of

troponine, creatine kinase MB, and myoglobin, the authors identified patients at very low risk

of a short-term major adverse cardiac event who might be suitable for early discharge.

Nevertheless, we are a little concerned about missing data of the TIMI score. The score

includes “three or more risk factors for coronary artery disease” (yes=1), and significant coronary stenosis at previous angiography (yes=1). We wondered if a patient without regular

health check-up was considered by authors as 0 or 1? This could be an important issue

considering the threshold considered (TIMI score ≥ 1= positive).We know for instance that people of low socioeconomic status have a lower access to healthcare whereas they have more

risk factors for coronary heart disease (2-4). However, without regular check-up, these people

would have a lower TIMI score than they should have.

In conclusion, we think that the accelerated diagnostic protocol should take into account the

absence of medical follow-up to consider data like social inequalities in health for instance.

References

1. Than M, Cullen L, Reid CM, Lim SH, Aldous S, Ardagh MW, et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet. 2011 mars 26;377(9771):1077-1084.

2. Kaplan GA, Keil JE. Socioeconomic factors and cardiovascular disease: a review of the literature. Circulation. 1993 oct;88(4 Pt 1):1973-1998.

3. Tyroler HA. The influence of socioeconomic factors on cardiovascular disease risk factor development. Prev Med. 1999 déc;29(6 Pt 2):S36-40.

4. Manrique-Garcia E, Sidorchuk A, Hallqvist J, Moradi T. Socioeconomic position and incidence of acute myocardial infarction: a meta-analysis. J Epidemiol Community Health. 2011 avr;65(4):301-309.

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