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The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

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Academic year: 2021

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Table 1    Overview of the patients selected for the study
Fig. 1    Quantification of aggregated αSYN in patients’ brains. a Sche- Sche-matic representation of the experimental setup
Fig. 2    Amplification of pathogenic αSYN from PD, MSA and DLB  patients by PMCA. PMCA was performed on human brain  homoge-nates (2% (W:V) for the 1st cycle, the indicated amounts (V:V) for  the next cycles, in PMCA buffer containing monomeric αSYN,  100
Fig. 3    In vitro characterization of patient-derived αSYN assem- assem-blies.  a Electron micrographs of αSYN assemblies obtained after  the 3rd cycle of amplification by PMCA from PD, MSA and DLB  patients and from de novo generated αSYN Fibrils and Rib
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