N6-methyladenine: the other methylated base of DNA.

HAL Id: inserm-00390682

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N6-methyladenine: the other methylated base of DNA.

David Ratel, Jean-Luc Ravanat, François Berger, Didier Wion

To cite this version:

David Ratel, Jean-Luc Ravanat, François Berger, Didier Wion. N6-methyladenine: the other methy-lated base of DNA.. BioEssays, Wiley-VCH Verlag, 2006, 28 (3), pp.309-15. �10.1002/bies.20342�. �inserm-00390682�

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Archaea

Eubacteria

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m6A m6A m6A m6A m6A m6A

m6A m6A m6A

T G Replication A B G C

m6A m6A m6A m6A m6A G_Cm6A

Methyl-directed mismatch repair

D

C

Bacterial virulence

transcriptional regulation through methylation of rare specific regulatory element(s)

functional interaction with m5C mismatch repair

transposon motility chromosome compaction immortal DNA strand imprinting mitochondrial genome imprinting

viral DNA imprinting prior to degradation What a few hundred m6A could do

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