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COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure.

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HAL Id: inserm-00232779

https://www.hal.inserm.fr/inserm-00232779

Submitted on 4 Sep 2009

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

and wood-dust exposure.

Reetta Holmila, Diane Cyr, Danièle Luce, Pirjo Heikkilä, Michael Dictor,

Torben Steiniche, Tuula Stjernvall, Jette Bornholdt, Håkan Wallin, Henrik

Wolff, et al.

To cite this version:

Reetta Holmila, Diane Cyr, Danièle Luce, Pirjo Heikkilä, Michael Dictor, et al.. COX-2 and p53 in hu-man sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure.. International Journal of Cancer, Wiley, 2008, 122 (9), pp.2154-2159. �10.1002/ijc.23360�. �inserm-00232779�

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0 5 10 15 20 25

Adenocarcinoma

Squamous cell carcinoma

COX-2 ++/+++ COX-2 -/+ 0 5 10 15 20 25

Adenocarcinoma

Squamous cell carcinoma

(4)

Adenocarcinoma

Squamous cell carcinoma

0 2 4 6 8 10 12

Wood-dust exposure No wood-dust exposure COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12

Wood-dust exposure No wood-dust exposure COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12 Smoker Non-smoker COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12 Smoker Non-smoker COX-2 ++/+++ COX-2 -/+

Adenocarcinoma

Squamous cell carcinoma

0 2 4 6 8 10 12

Wood-dust exposure No wood-dust exposure COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12

Wood-dust exposure No wood-dust exposure COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12 Smoker Non-smoker COX-2 ++/+++ COX-2 -/+ 0 2 4 6 8 10 12 Smoker Non-smoker COX-2 ++/+++ COX-2 -/+

(5)

0 50 100 150 200 250 300 350 400 450 FIN 48 ( - ) FIN 131 (++) FR 67 ( - ) FR 100 (++) FIN 81 (++) FR 15 ( - ) FIN 214 (++) FR 98 (+++) FIN 78 (++) FR 27 (+++) Relative Unit COX-2 index

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