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Predictive models of toxicity in intensity modulated radiotherapy

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HAL Id: tel-00855266

https://tel.archives-ouvertes.fr/tel-00855266

Submitted on 29 Aug 2013

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Predictive models of toxicity in intensity modulated

radiotherapy

Jian Zhu

To cite this version:

Jian Zhu. Predictive models of toxicity in intensity modulated radiotherapy. Signal and Image

pro-cessing. Université Rennes 1, 2013. English. �NNT : 2013REN1S017�. �tel-00855266�

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ANNÉE 2013

1

THÈSE / UNIVERSITÉ DE RENNES 1

sous le sceau de l’Université Européenne de Bretagne

pour le grade de

DOCTEUR DE L’UNIVERSITÉ DE RENNES 1

Mention : Traitement du Signal et Télécommunications

Ecole doctorale Matisse

présentée par

Jian ZHU

Préparée à l’unité de recherche LTSI – INSERM U1099

Laboratoire Traitement du Signal et de l’Image

Université de Rennes 1, France

Laboratory of Image Science & Technology (LIST)

Southeast University, Nanjing, Chine

Modèles prédictifs de

toxicité en

radiothérapie par

modulation

d’intensité

Soutenue à Nanjing, Chine

le 18/01/2013

devant le jury composé de :

Dimitri LEFKOPOULOS

Physicien Médical, Institut Gustave Roussy / rapporteur

Zhiguo GUI

Professeur, North University of China / rapporteur

Baosheng LI

PUPH, Shandong Cancer Hospital and Institute / examinateur

Renaud DE CREVOISIER

PUPH, Université de Rennes 1 / directeur de thèse

Limin LUO

Professeur, Southeast University / co-directeur de thèse

Antoine SIMON

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EFA1.E7ED1561A81DA1587ED1FA1.E7ED15A1D1451FA19F87ED1F'M=1FA1846A1561P1

1

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1A1659589A1ED81A1CA1AD1A16E91A1EFA1123C11A1FA1EFA19A6EAD8191A1CA1

451?1FA1856A1A1A1EFA11E78!561A81FA17484A7C13A6ADF5D81A1EFA1FA1295D1

5189E71659589AA1D

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(15)

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(16)

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(18)

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(19)

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Figure

Fig. 2. Predicted and observed NTCP for acute esophagitis in the group 2 (no concomitant chemo-radiotherapy) with the following LKB model parameters:

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