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Antifungal activities of amino acid ester functional pyrazolyl compounds against Fusarium oxysporum f.sp. albedinis and Saccharomyces cerevisiae yeast

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Academic year: 2021

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Antifungal activities of amino acid ester functional pyrazolyl compounds against

Fusarium oxysporum f.sp. albedinis and Saccharomyces cerevisiae yeast

Nouria Boussalaha, Rachid Touzani b,c, Faiza Sounad, Iman Himrid, Mohammed Bouakkad, Abdelkader Hakkoud,*, Said Ghalema and Sghir El Kadirib

aLaboratoire des Substances Naturelles et Bioactives, Département de Chimie, Faculté des Sciences, Université Abou Bekr Belkaid- Tlemcen, BP:119, Tlemcen 13000, Algeria.

bLaboratoire de Chimie Appliquée et Environnement, URAC18, Faculté des Sciences, Université Mohamed 1er, BP:524, 60000 Oujda, Morocco.

cFaculté Pluridisciplinaire de Nador, BP:300, Selouane 62700, Nador, Morocco.

dLaboratoire de Biochimie, Département de Biologie, Faculté des Sciences, Université Mohamed 1er, BP:524, 60000 Oujda, Morocco. Tel : (212)0536531414; fax: (212)0536531919.

*Corresponding Author. E-mail: kadahakkou@yahoo.fr

Abstract: Series of functional multidendate ligands based on pyrazole and amino acid

derivatives were prepared in good and excellent yields (75-85%) by condensation of one equivalent of amino acid ester hydrochloride substrates with two equivalents of (3,5-dimethyl-1H–pyrazol-1-yl)methanol. These tridentate functionalized compounds and their starting materials were screened for their antifungal activities against Fusarium oxysporum f.sp. albedinis and the yeast of Saccharomyces cerevisiae. Considerable activities were recorded with respect to the two studied microorganisms.

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