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Benzannulated Cycloheptanones from Binaphthyl Platforms

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Benzannulated Cycloheptanones from Binaphthyl Platforms

Authors

Grégory Pieters, Kamal Sbargoud, Alexandre Bridoux, Anne Gaucher, Sylvain Marque, Flavien Bourdreux, Jérôme Marrot, David Flot, Guillaume Wantz, Olivier Dautel, Damien Prim

Publication date 2013/1

Journal

European Journal of Organic Chemistry

Volume 2013 Issue 3 Pages 490-497 Publisher WILEY‐VCH Verlag Description

Preparations of benzannulated cycloheptanones starting from unique binaphthyl molecular platforms are described. Binaphthyl acetic acids proved suitable percursors for fused cycloheptanone architectures. Seven‐membered rings embedded in binaphthyl units were selectively generated by use of Eaton's reagent. Isomeric helical architectures arising from electrophilic cyclisation processes at second reaction sites in the precursors could also be obtained under different acidic conditions. Unambiguous discrimination between isomeric geometries was provided by multiple quantum NMR sequences. DFT calculations were performed and gave evidence of different behaviour of the substrates towards intramolecular electrophilic substitution. The theoretical approach confirmed the experimental results, agreeing completely with X‐ray data.

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