Eastern Mediterranean Health Journal, Vol. 12, No. 6, 2006 847
Misuse of topical corticosteroids: a clinical study in an Iraqi hospital
M.A. Al-Dhalimi1 and N. Aljawahiry2
1Department of Dermatology, College of Medicine, University of Kufa, Kufa, Iraq (Correspondence to M.A.
Al-Dhalimi: maldhalimi@yahoo.co.uk).
2Department of Clinical Pharmacy, Al-Najaf Health Office, Al-Najaf, Iraq.
Received: 19/01/05; accepted: 25/04/05
ABSTRACT We assessed the frequency of, reasons for and the most common dermatological problems resulting from misuse of topical corticosteroids. We used a questionnaire and skin examination to study patients presenting at the dermatological centre, Al-Sadr Teaching Hospital, Al-Najaf, Iraq during the period March 2001–April 2002. Of 1780 new patients, 140 (7.9%) had misused topical corticosteroids.
About half were aged 10–19 years. Potent and highly potent preparations were the most commonly used. In 34.3% of cases, medical staff were responsible for prescribing/recommending the drugs.
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Misuse of topical corticosteroids: a clinical study
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Utilisation abusive des dermocorticoïdes : étude clinique dans un hôpital iraquien
RÉSUMÉ Nous avons évalué la fréquence et les raisons de l’utilisation abusive des dermocorticoïdes ainsi que les problèmes dermatologiques qui en résultent. Nous avons utilisé un questionnaire et réalisé un examen cutané pour étudier les patients ayant consulté au centre dermatologique de l’hôpital univer-- sitaire Al-Sadr d’Al Najaf (Iraq) pendant la période mars 2001-avril 2002. Sur 1780 nouveaux patients, 140 (7,9 %) avaient utilisé des dermocorticoïdes de façon abusive. Environ la moitié d’entre eux étaient âgés de 10 à 19 ans. Les préparations de forte ou très forte activité étaient les plus couramment utili-- sées. Dans 34,3 % des cas, le personnel médical était responsable de la prescription/recommandation pharmaceutique.
Introduction
Since their introduction almost 50 years ago, topical corticosteroids have made a dramm matic contribution and been the mainstay of dermatologic treatment of a wide range of nonminfectious diseases [1,2]. Topical cormm ticosteroids are among the most commonly prescribedmedications in the ambulatory setting. The clinical effectsare mediated by their antiminflammatory,vasoconstrictive, antiproliferative and immunosuppressive properties. These result from their ability to exert multiple effects on various functions of leukocytes and epidermal and dermal cells [3,4].
The unwanted effects are directly related to their potency, and have become more prevalent with the introduction of high pomm tency topical corticosteroids. They include effects on the epidermis and the dermis in addition to those resulting from systemic absorption [5–11].
The increasing frequency of use of topical steroids has led to the detection of a number of clinical syndromes related to misuse such as perioral dermatitis, tinea incognito, impetigo incognito and infantile gluteal granuloma [1,12,13].
In recent years, haphazard use of the potent fluorinated topical steroids has been noticed among the general population in Iraq and was considered to be associated with increasing frequency of sidemeffects.
This study was carried out to assess the frequency of misuse of topical corticosmm teroids, the causes behind it and the most common problems resulting from it.
Methods
This study was carried out in the outpamm tient clinic of the Department of Dermatolmm ogy and Venereology in AlmSadr Teaching
Hospital, AlmNajaf, Iraq, during the period March 2001 to April 2002 on 1 day per week.
The patients studied were those who had used topical corticosteroids incorrectly (i.e. for conditions for which steroids are not indicated) for certain skin problems and presented with ≥ 1 of the side-effects of these drugs as the chief complaint. These included the appearance of ≥ 1 of the fol-m lowing signs: facial acne, facial hypertrimm chosis, cutaneous atrophy, stretch marks, hyper/hypopigmentation, tinea incognito, plethoric face and telangiectasia, infantile gluteal granuloma and pyoderma.
Patients were interviewed directly by the dermatologist using an anonymous questionnaire. Questions covered age, sex, education level, duration of treatment with topical corticosteroids, type and formulamm tion of the drug (lotion, cream, ointment, etc.), frequency of application and reason for using the drug. Patients were also asked who had prescribed/recommended the remmm edy [patient himself, friend, family memmm bers (i.e. overmthe counter), pharmacist, paramedical personnel, physician/general practitioner, other specialist or dermatolomm gist]. We asked if the patients knew of the sidemeffects of the drugs and if they had read the leaflet (package insert) before use. They were also asked if they knew the amount of drug that should be applied for each body area (dosage).
The skin conditions which prompted the patients to visit the dermatology clinic were registered and the clinical details recorded.
In addition, a full skin examination was performed to detect any condition related to abuse of topical steroids. Most diagnoses were exclusively clinical, and were based on typical, classical features. Potential systemic adverse effects were not investigated.
Results
Of the 1780 new patients seen in the Demm partment of Dermatology during the study period, 140 (7.9%) had misused topical corticosteroids. There were 95 (67.8%) females and 45 (32.2%) males. The ages of the patients ranged from 1 to 49 years (mean 18.7 years) (Table 1). About half the patients were aged 10–19 years. There were no refusals to participate in the study.
The mean duration of use was 5.5 months (range 1–60 months). Most patients had used the drugs for a short period, and were attending the department because of sidemeffects.
The patients used the drug in the form of a cream base in 36 (25.7%) cases and in the ointment form in 104 (74.2%) cases. The number of applications varied from 1/day to 3/day. The main topical corticosteroids used are summarized in Table 2. Potent and very potent preparations were used by 133 (95.0%) patients.
Thirtymseven (26.4%) patients had some idea of the sidemeffects of topical corticosmm teroids. Some patients had read the leaflet (package insert), but 122 (87.1%) had not, either because they were illiterate (54 pamm tients) or because the drug was supplied without a leaflet (82 patients). None of the patients knew the dosage, i.e. how much of the drug should be used for each particular body area.
The main reasons for using topical cormm ticosteroids included lightening of the skin in 92 (65.7%) patients and mild acne in 23 (16.4%) patients (Table 2). Some patients indicated > 1 reason for using these medicamm tions.
The people indicated by the respondents as being responsible for the incorrect use of the medications are shown in Table 2.
Most of the patients were either illiterate or could just read and write (63.6%), i.e.
had not completed secondary school. Only 7.2% had higher education (after secondary school).
Table 1 Age distribution of patients (n = 140)
Age group (years) No. %
1–9 17 12.1
10–19 69 49.3
20–29 38 27.1
30–39 12 8.6
40–49 4 2.9
Table 2 Distribution, source and reason for using the preparation in 140 patients who misused topical corticosteroids
Parameter No. %
Drug
Clobetasole propionate 0.05% 59 42.1 Betamethasone valerate 0.1% 37 26.4 Flucinolone acetonide 0.025% 17 12.1
Mixed (> 1) 14 10.0
Triamcinolone acetonide 0.1% 7 5.0 Hydrocortisone acetate 2.5% 6 4.3 Source of drug
Paramedical personnel 38 27.1 Self, friend or family membera 29 20.7
Pharmacist 26 18.6
Street vendor 25 17.9
Physician (non-dermatologist) 16 11.4
Dermatologist 6 4.3
Reason for using preparationb
Lightening the skin 92 65.7
Mild acne 23 16.4
Mild facial dryness 18 12.8
Napkin dermatitis 13 9.3
Pediculosis pubis 6 4.3
Scabies 5 3.5
Tinea corporis 4 2.8
aBy hand.
bSome patients indicated > 1 reason.
The dermatological abnormalities seen after application of topical corticosteroids are listed in Table 3. Acne and plethoric, puffy face with telangiectasia (steroid face) were the most common adverse effects noted. Stretch marks were seen in 17.1% of patients, none of them having the lesions on the face.
The number and degree of adverse cumm taneous effects was correlated with the duration of use (results not shown). About 73% of those who presented with an acnem type rash had sudden onset at the sites of application with predominance of papulomm pustular lesions. Unusual features (such as widespread lesions, inflammatory and or pustular features) were noticed in 75.0% of patients with dermatophyte infections.
Discussion
Although our results clearly showed that misuse of topical corticosteroids is commm mon in our country, 2 main criticisms can be made of our study. First, the dermatomm logical diagnoses were based mainly on clinical grounds and not confirmed by furmm ther investigation; this reflects dermatomm
logical practice in developing countries, where clinical accuracy for the diagnosis of common dermatoses appears to be good [14]. Moreover, the unusual features that we observed mainly showed an exaggermm ated pattern, rather than a really “atypical”
one, therefore making the diagnosis easier.
Second, most data were recorded using a questionnaire, and there may have been a reluctance by some patients, especially those who used the drug by themselves or on the advice of a friend or family member, to answer truthfully questions about the use of topical corticosteroids. Many patients did not know what topical corticosteroids were until they were shown samples of the drugs. This could have lead to an underm estimation in our evaluation of the frequenmm cy of the practice. Despite these limitations, our study provides data confirming the extensive and uncontrolled use of topical corticosteroids in Iraq.
Misuse appears to be a common problem in our country. This is reflected by the large proportion of patients who visit the Departmm ment of Dermatology with sidemeffects of these drugs. The real problem is probably even greater, as, at the time of the study, many people who had used these drugs may not have presented at the clinic or sidem effects had still not appeared.
Topical steroids have emerged in recent years as major skin lighteners owing to their potent bleaching power, and perhaps also their antiminflammatory activity, which can reduce the risk for dermatitis [9,10]. Skin lightening was the main reason for the use of the drugs (65.7%). This may also explain the female predominance (67.8%) in the patients we studied.
About half of the patients (49.2%) were in the 10–19 years age group. This was probably to be expected as this is the period when young people start to take care of their appearance.
Table 3 Dermatological abnormalities seen in 140 patients who misused topical corticosteroids
Condition No. %
Facial acne 51 36.4
Plethoric face and telangiectasia 31 22.1
Facial hypertrichosis 27 19.2
Cutaneous atrophy 24 17.1
Stretch marks 24 17.1
Hyper-hypopigmentation 20 14.3
Pyoderma 12 8.6
Tinea incognito 4 2.9
Infantile gluteal granuloma 2 1.4
Unfortunately, we found that most of the topical corticosteroids used were classed as potent or very potent. In spite of the fact that these drugs can cause such serious sidemeffects, they are sold without medical prescription or control.
In this study, the main burden of responmm sibility for the misuse of topical corticosmm teroids was put on paramedical personnel and the patient (plus friends or family).
This is probably an exaggeration since most products are easily available from street vendors (who were common in most cities of Iraq after sanctions were imposed, and increased in number after the invasion) or in nonmpharmaceutical shops without a medical prescription or seeing a doctor.
In fact, street vendors were the source of 17.9% of the drugs in this study. Secondary responsibility is carried by the pharmacists, general physicians and even some dermamm
tologists. This may bring the unethical and unprofessional practices of some pharmamm cists and doctors to light, despite patent protection and regulation of sales of potent topical corticosteroids. It may also reflect the shortcomings of the continuing medical education programme with regard to this problem.
In conclusion, the misuse of topical corticosteroids has a huge impact on dermm matological practice. It is responsible for a significant proportion of visits to dermatolmm ogy clinics. It is a multiphase problem that needs the cooperation of different sectors in the community to overcome it. Educamm tion of the general public through special media programmes and the introduction of a continuing medical education programme for medical and paramedical personnel are probably the most important steps that could be taken to reduce this problem.
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