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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network

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Academic year: 2021

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Figure 1. Chemotherapy increases TIL infiltration but transiently controls tumor growth
Figure 2. CP treatment barely affects the TuDC network within the tumor parenchyma. (A) Representative overlay histogram plot of CD11c and F4/80 expression gated on CD11b + Ly6G − myeloid cells within the MCA-OVA tumors, 7 days after CP treatment (blue) or
Figure 3. OTI T cells make Ag-dependent interactions with TuDCs. (A) Representative TPLSM images of OTI T cells (cyan) and YFP + stromal cells (green) within an MCA tumor and an MCA-OVA tumor, 4 days after OTI-CFP T cell adoptive transfer in a CP-treated
Figure 4. The proportion of TILs contacting TuDCs is enhanced after chemotherapy. OTI-DsRed T cells were adoptively transferred into CD11c-YFP transgenic mice bearing MCA-OVA tumor treated or not with CP
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