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Modeling cortical spreading depression induced by the hyperactivity of interneurons

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Academic year: 2021

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Figure 1: Diagram of the model. The model implements a pair of interconnected neurons, a pyramidal glutamatergic neuron (excitatory, E) and a GABAergic interneuron (inhibitory, I)
Figure 2: Inhibitory effect of the interneuron spiking at moderate frequency. When the interneuron is set to fire at about 40Hz (J i = 0.6), it exerts an inhibitory action on the firing of the pyramidal cell
Figure 3: The firing frequency of the interneuron and the potassium efflux that it generates are parameters that can generate different spiking patterns of the pyramidal cell
Figure 4: Slow spiking of the pyramidal neuron can turn to spreading depression due to intense interneuron firing that induces extracellular potassium build-up
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