Research Article Title
PET amyloid in normal aging: direct comparison of visual and automatic processing methods
Short Title:
Amyloid PET analysis methods
Authors
Sven HALLER a,b,c
Marie-Louise MONTANDON d,e Johan LILJA b, f, g
Cristelle RODRIGUEZ e,h Valentina GARIBOTTO c,i, François R. HERRMANN d
Panteleimon GIANNAKOPOULOS e,h
Affiliations
a CIRD Centre d’imagerie Rive Droite, Geneva, Switzerland
b Department of Surgical Sciences, Radiology, Uppsala University, Sweden c Faculty of Medicine, University of Geneva, Switzerland
d Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Switzerland
e Department of Psychiatry, University of Geneva, Switzerland
f Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden
g Hermes Medical Solutions, Stockholm, Sweden
h Division of Institutional Measures, Medical Direction, Geneva University Hospitals, Switzerland
i Division of Nuclear Medicine and Molecular Imaging, Diagnostic Department, Geneva University Hospitals, Switzerland
Corresponding Author Prof. Dr. M.Sc. Sven Haller
1 CIRD Centre d’imagerie Rive Droite, Geneva, Switzerland
2 Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
3 Faculty of Medicine of the University of Geneva, Switzerland [email protected]
Keywords:
aging, hippocampus, amyloid, PET
Supplementary Figure 1
-2-1.8-1.6-1.4-1.2
.07 1.09
Average of Automatic Aβ-index and cerebellum gray matter 10/155 = 6.45% outside the limits of agreement
Mean difference -1.624 95% limits of agreement (-1.843,-1.405)
Averages lie between 0.071 and 1.094
-1.5-1-.5
-.12 .50
Average of Automatic Aβ-index and pons 8/155 = 5.16% outside the limits of agreement
Mean difference -0.970 95% limits of agreement (-1.320,-0.621)
Averages lie between -0.125 and 0.500
-1.6-1.4-1.2-1
.02 .85
Average of Automatic Aβ-index and Whole cerebellum 9/155 = 5.81% outside the limits of agreement
Mean difference -1.352 95% limits of agreement (-1.568,-1.136)
Averages lie between 0.021 and 0.850
-1.6-1.4-1.2-1-.8
.001 .76
Average of Automatic Aβ-index and whole cerebellum + brain stem 9/155 = 5.81% outside the limits of agreement
Mean difference -1.262 95% limits of agreement (-1.507,-1.017)
Averages lie between 0.001 and 0.759
Difference(AutomaticAβ-index -Wholecerebellum) Difference(AutomaticAβ-index -wholecerebellum+ brainstemDifference(AutomaticAβ-index –pons)
Difference(AutomaticAβ-index -cerebellumgray matter)
Supplementary Figure 1: Representative Bland-Altman plots for the automatic Aβ- index in different brain reference regions.
