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Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

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Academic year: 2021

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Figure

Table 1 Primers for LDLR Sanger sequencing and targeted insertion used in this study
Table 2 RT-PCR and RT-qPCR primers used in this study
Table 3 Primary and secondary antibodies used in this study
Fig. 1 FH-iPSCs recapitulate FH phenotype in vitro. a DNA sequences depicting the mutated nucleotide g.10891C>T (c.97C->T, p.Q12X) in the LDLR exon 2 in FH-patient ’ s fibroblasts and iPSCs by contrast to normal human fibroblasts (Ctl)
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